1.Study on Hepatitis B and C exposure in nurses
Batbold D ; Badamjav S ; Chimedsuren O ; Baatarkhuu.O
Mongolian Medical Sciences 2015;172(2):60-64
Introduction.M.Colombo, W.Lange studies showed that 30-40% of people became chronic after suffering fromHepatitis B and C virus, about 50% of chronic cases transformed into primary liver cancer. There arefew studies in our country were conducted on hepatitis among healthcare professionals, particularnursing personnel.Goal.To identify antigens and antibodies of hepatitis B and C virus among nursesMaterials and Method.We carried out cross-sectional study among selected nurses, to determine surface antigen of hepatitisB virus and antibodies to hepatitis C virus. For identification of these antibodies and antigen, andvalidation of results Serodia tests from Fujinebo Company (Japan) and Beringnost (Germany) wereused respectively.Results.There were 598 nurses from the State Central Clinical Hospital, Shastin’s State Hospital, Hospitalof Military of Justice and Internal Affairs, and the National Center of Maternal and Child Health, whoparticipated in the study. From 5 hospitals a 598 nurses surveyed and revealed the hepatitis B virussurface antigen positive 18.9%, hepatitis C virus antibodies in 23.2%, B and C viruses detected by1.2% combined.Conclusion.The study identified that 43.2 percent of nurses surveyed on hepatitis B and C viruses were detected;it shows a high prevalence among the nurses. There is an urgent need to provide knowledge tomedical personnel regarding standards during procedures, concerning hepatitis infections, monitoringand improve technology used during procedures.
2.Influence of rs16924159 polymorphism of IL-33 gene on asthma susceptibility
Chimedlkhamsuren G ; Uyangakhorol N ; Batbold O ; Ichinnorov D ; Sarantuya J
Innovation 2020;14(2):67-71
Background:
Interleukin-33 (IL-33) cytokine plays a crucial role in asthma pathogenesis. Recent
studies have established that IL-33 activity was increased in serum, airway smooth muscle and
epithelial cells from patients with asthma and this increase positively correlates with asthma
severity. We hypothesized that several genetic variations that contributing IL-33 expression
and activity, which may risk factor for susceptibility to asthma. In this study, we examined the
association between rs16924159 single nucleotide polymorphism (SNP) of IL-33 gene and asthma
susceptibility.
Methods:
51 asthma patients and 54 healthy volunteers were involved in this case-control
study. Blood sample was collected for genomic DNA extraction. rs16924159 SNP genotyping was
performed by the allele specific-polymerase chain reaction (AS-PCR) method. Statistical analysis
was performed using STATA 13.0 software.
Results:
The groups were matched for age, gender and body mass index (p>0.05). The distribution
of rs16924159 allele and genotypes among patients and controls was found in accordance with
those expected by the Hardy-Weinberg equilibrium (p=0.088). Adenine (A) allele frequency of
rs16924159 was significantly different between case and control groups (OR = 1.91, 95% CI = 1.04-
3.51, p = 0.037). Also, homozygote A/A (OR=6.53, 95% CI 0.68-62.38, p=0.104) and heterozygote
(OR=2.08, 95% CI 0.93-4.62, p=0.073) genotypes were more frequent among asthma patients than
in controls.
Conclusions
From these findings, we conclude the A allele of rs16924159 SNP in IL-33 gene
may be contributing to asthma susceptibility, increasing the carrier`s risk to the development of
asthma.