Background: Research of histo and cytometry in comparative healthy and pathological condition is not so much in our country. Therefore, it is making a demand to do stereometrical research study on tissues, cells and nucleus.Goal: To study and to determine stereometrical indices, mathematic model of hepatocytes and nucleus in condition of comparatively healthy, acute intoxication, chronic inflammation and cancer of Mongolians.Materials and Methods: It was prepared sections for histometric materials. Linear measurements of hepatocytes and nucleus were carried out by computer-microscope “Leica” with program Diskus 3.2 version from German. On linear measurement in condition of comparatively healthy, acute intoxication, chronic inflammation and cancer were processed by mathematic modeling.Results: Volume distribution of hepatocyte’s cytoplasm χ2st=15.51>χ2 F=4.31; (P<0.001), and hepatocyte’s nucleus χ2 st=12.59>χ2 F=10.74 in comparatively healthy (normal) conditions pursues normal distribution formula, however, the volume of hepatocyte’s cytoplasm and nucleus follows Maxwell formula of abnormal distribution χ2 st=23.68>χ2 F=10.44; (P<0.001), χ2 st=15.51>χ2 F=6.90; (P<0.001) in a condition of acute intoxication and volume of hepatocyte’s cytoplasm and nucleus χ2 st=23.68>χ2 F=8.03; (P<0.001), χ2 st=15.51>χ2 F=4.32; (P<0.001) in a condition of chronic inflammation. And volume distribution of hepatocyte’s cytoplasm χ2 st=8.27>χ2F=19.68; (P<0.001), and hepatocyte’s nucleus χ2st=3.41>χ2F=3.82 incondition of cancer. There is no statistically significant difference (P<0.001) between observation and theoretical frequencies of average values of hepatocyte’s cytoplasm and nucleus volume, which confirms that the result is true and accurate.Conclusions:1. Volume of hepatocyte’s cytoplasm is 2184.18±36.98 mkm3 in comparatively healthy (normal) conditions, 4153.17±84.18 mkm3 in a condition of acute intoxication, 4887.84±75.51 mkm3 in a condition of chronic inflammation and 13143.88±4.29 mkm3 in a cancer condition. Volume of nucleus is 299.94±36.98 mkm3 in comparatively healthy (normal) conditions, 873.59±13.86 mkm3 in a condition of acute intoxication, 888.65±13.51 mkm3 in a condition of chronic inflammation and 2924.57±2.12 mkm3 in a cancer condition.2. Volume of hepatocyte’s cytoplasm was increased 2 times, volume of hepatocyte’s nucleus was increased 3 times in a condition of acute intoxication and volume of hepatocyte’s cytoplasm was increased 2.2 times, volume of hepatocyte’s nucleus was increased 2.9 times (P< 0.001) in a condition of chronic inflammation. However volume of hepatocyte’s cytoplasm was increased 6.5 times, volume of hepatocyte’s nucleus was increased 9.7 times in a condition of cancer.

Background: Squamous cell carcinoma, which accounts for 90-95% of oral cancer, arises from the uncontrolled and disordered growth of keratinocyte cells in the mucous of lip and oral cavity. It occupies 2-3% of all cancers and 38% of head and neck cancers. Aim: To study recurrence and prognosis of patients with tongue squamous cell carcinoma Materials and Мethods: Our study, based on retrospective cohort method was conducted from medical reports of 207 patients who were diagnosed with squamous cell carcinoma of oral cancer and at the Department of Head and Neck Surgery, Radio and Chemotherapy of the National Cancer Center of Mongolia between 2009-2019 years. All statistical analysis were carried out using STATA version 15.0 and we performed survival analysis using Kaplan-Meier method. All statistical tests were two sided, and P-values less than 0.05 were considered significant. The study was approved by the Research Ethics Committee of the Mongolian National University of Medical Sciences on June 08, 2021 (№ 2021/3-07). Results: A total of 207 oral cancer cases were registered during the study period. The most common site of oral cancer was the tongue (47.3%, 98/207). Of these, cases 69.4% (68) presented in males and 30.6% (30) in females. At the time of diagnosis, 77 patients (78.5%) were in late stage (III, IV) and 76 cases (77.6%) were well-differentiated. During the study period, 20 patients (20.4%) experienced tongue cancer recurrence; female patients (18.8%, 3/20) had significantly less chance of recurrence compared to men (81.2%, 17/20), (p=0.033). Patients over 61 years old had higher oral cancer recurrence than patients under 60 years, but there was no significant difference in age groups. 90.6% (18/20) of tongue cancer recurrence had with lymph node metastasis; compared to patients without lymph node metastasis (9.4%, 2/20), tongue cancer recurrence was significantly higher (p=0.025). And there was a statistical difference in tongue cancer recurrence percentage among clinical stages (p=0.003). Thirteen (69.4%) patients diagnosed in stage IV had oral cancer recurrence. Pathological grading, and tumor size did not significantly influence cancer recurrence. Conclusion 1. The gender, advanced stage and lymph node metastasis of patients with tongue cancer were significantly associated with the presence of tongue cancer recurrence. (p=0.033, p=0.025, p=0.003). 2. The 5-year survival rate for tongue cancer was the lowest among the oral cancer, which we consider to be due to factors such as late-stage diagnosis, and anatomical characteristics of tongue.