Jonsh-5 is composed of 5 components including calcite, Cardius crispus, Forsythia suspense, Terminalia Chebula, and Inula helenium. Aim of this study is to examine the effect of traditional drug Jonsh-5 on experimental femur fracture in rats. Jonsh-5 was given to rats for 28 days. Calcium D3-Nycomed (2.5 g/kg) was used for comparison. 2, 14, and 28 days after fracture, serum levels of alkaline phosphatase were determined and fracture healing processes were evaluated by X-ray. Serum level of alkaline phosphatase was 197 u/l before fracture. After 7 days of fracture, alkaline phosphatase level was significantly increased by Jonsh-5 (728 u/l) and there were no statistical differences observed in rats with no treatment (control) and Calcium D3-Nycomed-treated animals. Similar patterns were observed 14 and 21 days after fracture. X-ray images showed that healing process of the bone was significantly increased by Jonsh-5 compare to control and Calcium D3-Nycomed treatment. Jonsh-5 may promote bone healing in rat model of fracture.