Objective To evaluate the influence of family intervention mode in patients with schizophrenia characterized by negative symptoms.Methods A total of 120 cases of hospitalized patients with schizophrenia characterized by negative symptoms were randomly divided into the observation group and the control group with 60 cases in each group.The observation group received treatment through family intervention mode based upon routine care,while the control group used routine care.Influences were assessed with Nurses’ Observation Scale for Inpatient Evaluation (NOSIE) and the Scale for Assessment of Negative Symptoms (SANS) before treatment and at the end of 6th,12th week treatment.Results No significant difference of NOSIE score or SANS score were found upon admission between the observation group and the control group.At the end of the 6th week or the 12th week,total and all factors’ scores of the NOSIE and SANS of both groups were better compared with pretreatment,the observation group was significantly better than the control group.Conclusions Family intervention model could significantly relieve the negative symptoms of schizophrenia,improve the patients’ clinical efficacy and is an effective adjunctive therapy for schizophrenia.