ObjectiveTo investigate the clinical efficacy of hydroxyethyl starch 130/0.4 and sodium chloride injection in the treatment of patients with early hemorrhagic shock (HS).MethodsFifty-two cases of early HS were divided into compound sodium chloride injection group(control group,26 cases) and hydroxyethyl starch 130/0.4 sodium chloride injection group (treatment group,26 cases) by random digits table.The clinical effect,mean arterial pressure (MAP),respiratory rate (RR) and heart rate (HR) and serum sodium,serum chloride and prothrombin time(PT) were statistically analyzed before and after treatment for 60 min.ResultsCure rates in treatment group and control group were 84.6％ (22/26) and 38.5％ (10/26),and mortality rates were 15.4％ (4/26) and 61.5％ (16/26),respectively.The difference showed statistical significant(P ＜0.05).MAP,HR and RR in treatment group were obviously improved compared with control group[ (91.5 ± 8.6 )mm Hg( 1 mm Hg =0.133 kPa) vs.(78.5 ± 7.9 )mm H8,( 81.5 ±8.6) times/min vs.( 108.4 ± 10.2) times/min,(21.4 ± 5.3) times/min vs.(25.5 ± 4.6) times/min,P ＜ 0.05 ].Compared with control group,serum sodium,serum chloride and PT in treatment group were no significant difference(P ＞0.05).ConclusionHydroxyethyl starch 130/0.4 and sodium chloride injection could increase the effective circulating blood volume,and improve tissue and organ perfusion and reduce mortality during the patients with early HS.

Objective:To investigate the association between Cyclin D1 and metastasis and determine the relationship between Cyclin D1 proteins expression and P21 WAF1?P53 proteins in ovarian cancer.Methods:Cyclin D1,P21 WAF1 and P53 proteins were detected from 61 ovarian carcinoma and 7 ovarian tissues without cancer by using Western blot method.Results:The positive rate of Cyclin D1 and P53 proteins expression in cases with ovarian cancer were significantly higher than those in without cancer tissues(P0.05).However, the expression of P21 WAF1 protein was correlated with clinical stages(P0.05).The expression of Cyclin D1,P53 and P21 WAF1 protein in ovarian carcinoma were related to metastasis(P

Objective To investigate the differential diagnosis of Reye syndrome and the characteristics of primary carnitine deficiency,and to provide diagnostic strategy for similar cases.Methods There was a case presented with fever,poor response,convulsions and hepatomegaly hospitalized in Wuhan Children's Hospital,and the clinical manifestations were described,the physical examination was comprehensively conducted,the auxiliary examination results were recorded,some pediatric specialists from ICU,neurology department,genetic metabolic department,digestive system department were invited to discuss the case.The treatment was adjusted according to the suggested opinions;the treatment effects and the final diagnosis were tracked.Results The primary diagnosis of the case was central nervous system infection or toxic encephalopathy at the time of admission,but Reye syndrome could not be excluded.Although the cerebrospinal fluid test and brain MRI examination detected nothing abnormal,liver function suggested alanine aminotrans ferase ALT increase,blood sugar decrease,the liver volume increase,which was detected by liver ultrasound.Blood amino acids examination revealed the carnitine level decreased,and it was confirmed as primary carnitine deficiency in the end.L-carnitine was used to treat the disease,and its effect was good.Conclusions Great importance should be attached to children with onset age,physical check-up,and multidisciplinary cooperation.Use monism to explain the illness and the auxiliary inspection as far as possible,so that it can get early diagnosis and treatment,and the outcome is good.

Objective To compare the efficacy of total pelvic floor reconstruction with mesh patch and vaginal hysterectomy with anterior and posterior vaginal wall repair for presby-pelvic floor dysfunction patients.Methods We randomly chose 92 pelvic floor dysfunction inpatients of our hospital from September 2007 to February 2009 and divided them into 2 groups:total pelvic floor reconstruction group(n=70) underwent total pelvic floor reconstruction with mesh patch[12 patients of this group complicated with stress incontinence,4 patients received tension free vaginal tape-obturator(TVT-O) simultaneously];control group(n=22) received vaginal hysterectomy with anterior and posterior vaginal wall repair(3 patients of this group complicated with stress incontinence).A follow-up for 3 to 18 months after the surgery were taken in all the patients.Results In total pelvic floor reconstruction group,no recidivate case was found and the FOP scores and cure rate were 0 and 100% respectively.In control group,there were 7 recidivate cases,all of who were primary vagina anterior wall bulge patients.The cure rate of control group was 68%;For the patients complicated with stress incontinence,they were all cured by TVT-0 or by ascending the front patch in total pelvic floor reconstruction group,but 1 case was as before operation and 2 cases were even worse in control group.Conclusion Total pelvic floor reconstruction with vicarious materials had a definite efficacy for presby-pelvic floor dysfunction.

OBJECTIVE To analyze and evaluate the comsumption of the antibacterial drugs during surgery operation in our hospital objectively.METHODS To carry out statistical analysis of antibacterial drugs from May to Dec in 2007.RESULTS The 93 percent of preventive usage of antibacterial drugs were in 2 hours after operation.The most was cephalosporins.CONCLUSIONS It is important to enhance the education of rational use and supervision.

OBJECTIVE:To observe the effects of butylphthalide combined with alteplase on neural funetion and cognitive function and serological indexes as homocysteine(Hcy)in patients with acute cerebral infarction(ACI).METHODS:Clinical information of 78 ACI patients in emergency department of our hospital during Feb.2140-Apr.2017 were analyzed and then divided into control group and observation group according to therapy plan,with 39 cases in each group. Both groups received conventional treatment and Aspirin enteric-coated tablets orally. Control group was given Alteplase for injection 0.9 mg/kg for verous thromblysis on the basis of conventional treatment. Observation group was additionally given Butyphthalide soft capsules 0.2 g orally,tid,on the basis of control group. Both groups were treated for consecutive 28 days. The clinical efficacies of 2 groups were observed. NIHSS and MMSE scores before treatment,3,7,14 and 28 d after treatment,the levels of Hcy,NSE and 6-k-PGF1a were observed in 2 groups;the occurrence of ADR was recorded. RESULTS:After treatment,total response rate of observation group was 92.31%,which was significantly higher than 71.79% of control group,with statistical significance(P<0.05). 3-28 d after treatment,NIHSS scores of 2 groups were decreased gradually and significantly lower than before treatment;MMSE scores of 2 groups were increased gradually and significantly higher than before treatment,with statistical significance(P<0.05 or P<0.01). 7-28 d after treatment,NIHSS score of observation group was significantly lower than that of control group at same time,while MMSE score was significantly higher than control group, with statistical significance(P<0.05 or P<0.01). After treatment,serum levels of Hcy and NSE in 2 groups were decreased significantly,and observation group was significantly lower than control group;the level of 6-k-PGF1a was increased significantly,and observation group was significantly higher than control group,with statistical significance(P<0.05 or P<0.01). There was no statistical significantce in the total incidence of ADR between 2 groups(P>0.05). CONCLUSIONS:Butylphthalide combined with alteplase can significantly improve neurologic impairment and cognitive function of ACI patients,reduce serum levels of Hcy and NSE and increase the level of 6-k-PGF1a. Clinical efficacy of it is significantly better than alteplase alone.

Objective:To learn about the cognition of iodine deficiency disorders (IDD) prevention knowledge among key population in the IDD area of Jilin Province, and to evaluate the effect of health education.Methods:From 2015 to 2019, 10 counties (cities, districts, hereinafter referred to as counties) in Jilin Province were selected as project counties every year. Public health education covered the entire project county. In each project county, 3 project townships were selected, and students of grades 4-6 were selected from the central primary schools of each project township for school health education. In each project township, 3 project villages were selected to carry out community health education. Before and after health education, 30 fifth-grade students were selected from the central primary school of each project township, and 15 housewives were selected from the vicinity of each primary school to conduct a questionnaire survey on IDD prevention knowledge.Results:After health education, the overall awareness rate of IDD prevention knowledge among primary school students and housewives in Jilin Province was 96.26% (13 324/13 842) and 96.40% (6 819/7 074), which was significantly higher than that before the intervention [65.36% (9 032/13 818) and 71.26% (5 039/7 071)], and the differences were statistically significant (χ 2 = 4 258.34, 1 647.92, P < 0.001), and the awareness rates of primary school students and housewives increased by 30.90% and 25.14%, respectively. Conclusion:Health education has significantly increased the awareness rate of IDD prevention knowledge among key populations in Jilin Province, and is an important measure to ensure the continuous elimination of IDD.

A fluorescent microsphere-based immunochromatographic strip test (FICT) was developed for the rapid, sensitive, and quantitative detection of porcine reproductive and respiratory syndrome virus (PRRSV) antibodies at the pen-side. The assay was based on the formation of a sandwich immune-complex (anti-pig IgG-PRRSV antibodies-NSP7/N), which was validated by a comparison with IDEXX-ELISA using 3325 clinical specimens. The diagnostic specificity, sensitivity, and accuracy of FICT were 97.28, 93.41, and 94.95%, respectively. FICT showed a good correlation with the virus neutralization assay. Overall, a promising pen-side diagnostic tool was developed for the rapid and quantitative detection of PRRSV antibodies within 15 min.

Objective    To explore the value of artificial intelligence (AI) diagnostic imaging system and three dimensional computed tomographic bronchoangiography (3D-CTBA) surgical planning system in the management of multiple primary lung cancer (MPLC). Methods    The clinical data of 53 patients with MPLC treated surgically in our hospital from January 2018 to August 2020 were retrospectively analyzed, including 16 males and 37 females, with a median age of 60 (39-75) years. The patients' preoperative CT was analyzed by AI and manually, and the data of patients who underwent 3D-CTBA were compiled to evaluate the value of AI and 3D-CTBA in the diagnosis and treatment of MPLC, respectively. Results     The sensitivity of AI screening for MPLC was 84.91%. The sensitivity (91.90% vs. 83.78%) and accuracy (85.60% vs. 84.00%) of AI diagnosis of high-risk MPLC infiltrative lesions were better than those of manual diagnosis. 3D-CTBA was used for planning the surgery in 12 patients, and the intraoperative situation was generally consistent with the reconstructed results. Conclusion    AI is of high value in identifying infiltrative lesions of MPLC. 3D-CTBA reconstruction of anatomical structures is accurate and can guide preoperative planning.