1.Analysis and Evaluation on Degassing Effect of Vacuum Degassing Apparatus
Bin CHEN ; Baoming NING ; Long ZHANG
China Pharmacist 2014;(5):880-881
Objective:To analyze and evaluate the degassing effect of vacuum degassing apparatus through the determination of ox-ygen content in pure water, gas pressure and air volume, and compare with suction filtration, boiling and ultrasonic methods to choose the appropriate degassing method for dissolution medium and guide the daily inspection work. Methods: The water residual oxygen, gas pressure and air volume were determined using a single water quality on-line monitoring instrument and a Carbo QC Anton Pear in-strument. The degassing effect of the vacuum degassing apparatus was detected under the conditions of negative pressure and certain de-gassing time. The degassing effect was also compared with that of suction filter, boiling and ultrasonic methods. Results: Under the conditions of 0. 06 MPa negative pressure, 41℃ medium temperature and 30 min degassing time, the degassing effect of the vacuum degassing apparatus was obvious. The degassing effect of suction filter and boiling methods was similar to that of the vacuum degassing apparatus, while that of ultrasonic method wasn't obvious. Conclusion:The use of vacuum degassing apparatus is simple and efficient with obvious degassing effect, which is suitable for the degassing process of dissolution medium.
2.Realization of remote wireless data transmission in mobile monitoring terminal of pre-hospital first aid
Wei CHEN ; Baoming WU ; Jinzhao LIN
Chinese Medical Equipment Journal 2003;0(12):-
Objective To realize remote wireless data transmission in mobile monitoring terminal of pre-hospital first aid so as to enhance the effect of pre-hospital aid,guarantee the reliability and real-time state of data transmission in mobile monitoring terminal of pre-hospital first aid.Methods The software and hardware of the mobile monitoring terminal of pre-hospital first aid were designed.Then,according to the specialty of the data transmission and requirements of the bandwidth,the choice of wireless network and the transport layer protocol of data transmission were analyzed,and the technology approach fitting for the system were proposed.The protocols selected were PPP and TCP/IP based on ?C/OS-Ⅱ.Results Application tests showed that this approach could satisfy system's requirement.It could transmit patient's vital signs parameters to hospital's monitoring equipment exactly in real-time during pre-hospital first aid.Conclusion This design creates the condition for remote hospital guide,resources planning of patient's admission and analysis of illness state,which is feasible for application.
3.Application of Color Doppler Flow Imaging in Portal Vein Chemotherapy by Ultrasound Guided Percutaneous Transhepatic Portal Injection
Baoming LUO ; Jinfang LI ; Yajin CHEN ;
Chinese Journal of Ultrasonography 1997;0(06):-
To evaluate the role of color Doppler flow imaging in the portal vein chemotherapy by ultrasound guided percutaneous transhepatic portal injection, the blood supply of liver tumor and portal hemodynamics were studied in 15 patients with primary hepatic carcinoma and one patient with secondary hepatic carcinoma. The continuous wave in the lesion and forward continuous wave in the portal vein seen by pulsed Doppler in nine cases, were indications for this therapeutic method. The distribution of the drugs in the liver could be observed by color Doppler flow imaging when injection was being done. The therapeutic efficacy of portal vein chemotherapy in liver tumor may be evaluated by color Doppler folw imaging and puncture biopsy.
5.Preoperative diagnostic value of ~(131)I-SPECT/CT fusion images in detecting the cervical and superior mediastinal metastases of DTC
Jiangong WANG ; Jun LI ; Wanning HU ; Baoming CHEN ; Ruishan ZHANG
Chinese Archives of Otolaryngology-Head and Neck Surgery 2006;0(04):-
OBJECTIVE To investigate the diagnostic value of 131I-SPECT/CT fusion images in detecting the metastases of differentiated thyroid carcinoma(DTC)in the regions of the head,neck and superior mediastinum.METHODS 131I-SPECT/CT fusion images was preformed for 30 patients with DTC,and the results of image were compared with the pathology after surgery.RESULTS There were 110 cases positive findings in 115 metastatic lesions with 131I-SPECT/CT fusion images examination(95.65%).5 cases of the metastatic lesions showed negative in 131I-SPECT/CT(4.35%).There was no false positive case.CONCLUSION 131I-SPECT/CT fusion images can detect and locate the metastasis and exclude the false positive results accurately.It is a good method to detect the cervical and superior mediastinal metastatic lesion in differentiated thyroid carcinoma.
6.A new terpenoid from Ganoderma lucidum.
Chao LIU ; Baoming LI ; Jie KANG ; Hongqing WANG ; Ruoyun CHEN
Acta Pharmaceutica Sinica 2013;48(9):1450-2
A new terpenoid, lucidone D (1), has been isolated from Ganoderma lucidum. Its structure was determined to be 7beta, 15alpha-dihydroxy-4, 4, 14alpha-trimethyl-3, 11, 20-trioxo-5alpha-pregn-8-en on the basis of 1D and 2D-NMR spectral analysis.
7.Role and significance of long non-coding RNA in pancreatic cancer
Boyi CHEN ; Jiansheng LIU ; Xing HAO ; Baoming ZHANG
International Journal of Surgery 2016;43(12):861-864
Pancreatic cancer is one malignancy with high aggressive and extremely poor prognosis,its incidence and mortality rates are increasing gradually in our country.Although surgical techniques and adjuvant drug therapy are improving,survival of patients with pancreatic cancer still has not been significantly improved.Long non-coding RNA are a class of non-coding transcripts longer than 200 nucleotides.Recent studies show long non-coding RNA is closely related to pancreatic cancer cells,apoptosis,metastasis and drug resistance.LncRNA plays an important role in the diagnosis,treatment and prognosis of pancreatic cancer.In this article we reviewed the role of long noncoding RNA and their significance in pancreatic carcinoma.
8.Comparative study of superb microvascular imaging and contrast-enhanced ultrasonographic microvascular imaging in diagnosis of breast tumor
Xin CHEN ; Baoming LUO ; Xiaofeng GUAN ; Huan WU ; Xiaoyun XIAO
Chinese Journal of Ultrasonography 2016;25(7):608-611
Objective To compare the diagnostic efficiency of superb microvascular imaging (SMI) and contrast-enhanced ultrasonographic microvascular imaging (MVI) for differentiating breast lesions.Methods One hundred and sixteen patients with 116 breast lesions were first examined by grayscale ultrasound.Then SMI and MVI were performed on all patients.Microvascular architectures of breast lesions were depicted by both methods.The lesions were evaluated based on their microvascular architectures.The diagnostic efficacy of both methods were compared.Results The diagnostic sensitivity,specificity,and accuracy of SMI and MVI were 79.24%,90.48 %,85.35% and 88.68%,87.30%,87.93%,respectively.The areas under the curve of SMI and MVI were 0.888 and 0.926.The diagnostic values of SMI and MVI were not statistically different (P =0.212).Conclusions SMI can detect tiny vessels and depict microvascular architecture of breast lesions as MVI do,which is beneficial for breast tumor differentiation.The diagnostic efficacy of SMI is almost the same as MVI.
9.Study on moisture-proof of extract granule by film coating in Biantong Capsule
Hong LU ; Liming CHEN ; Baoming WU ; Shengjie ZHU ; Zhihua CAO ;
Chinese Traditional Patent Medicine 1992;0(03):-
Objective: In order to solve the problem of moisture absorption for Biantong Capsule, the extract granule of Chinese medicine is covered with HPMC for Biantong Capsule. Methods: Taking moisture absorption rate as measure index, various facters effected the moisture absorption rate, and the optimal coating process can be selected with well disturbed uniform design and computer analog test. Results: Under the condition of 25℃, relative moisture 75% and 100% respectively, the moisture absorption rate is lower than uncovered granules, the critic relative moisture of covered granules is greater than that of uncovered granules. Conclusion: Chinese medicine of Biantong Capsule covered with HPCM can be served as a good anti moisture method.
10.Cucurmosin induced the apoptosis of pancreatic cancer cell SW1990 via EGFR signaling pathway
Baoming ZHANG ; Heguang HUANG ; Jieming XIE ; Minghuang CHEN ; Congfei WANG ; Qiang YIN ; Aiqin YANG
Chinese Journal of Hepatobiliary Surgery 2012;18(9):700-703
Objective To investigate the mechanisms involved in cucurmosin-induced apoptosis of pancreatic cancer cell SW1990.Methods The expression of EGFR,PI3K,Akt,Bad,Caspase -9,mTOR,P70S6K-α,and 4E BP1 at the protein level were detected by western blot analysis,and RTPCR was used to determine EGFR mRNA expression.Results An increased concentration of cucurmosin showed a subsequent decrease in the expression of EGFR,PI3K,Akt,mTOR,P70S6Kα,and 4E -BP1,whereasthe expression of Bad and Caspase-9 were elevated.However,the mRNA expression of EGFR was unchanged.Conclusion Cucurmosin is shown to induce the apoptosis of pancreatic cancer cell SW1990 by down regulating the expression of EGFR and thus inactivating the PI3K/Akt/mTOR signaling pathway.