Objective To discuss the relationship between GULP1 gene polymorphism of Chinese Han population and schizophrenia,cognitive function.Methods Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method was used to detect 86 patients with schizophrenia and 72 normal controls GULP1 gene SNPrs2004888 polymorphism;Wechsler Memory Scale(WMS) and Wisconsin Card Sorting Test(WCST) assessment of two groups of memory and executive function,and assessed with the PANSS scale clinical symptoms.Results The differences of GULP1 gene SNP(rs2004888) polymorphism genotype and allele frequency was statistically significant (χ2 = 35.71、32.21,all P＜0.05).Genotypes in patients with group comparison of cognitive function between groups showed the genotype groups Wechsler Memory Scale Logical Memory scores were significant(P＜0.05),G/G and T/T genotype compared with the Wisconsin Card Sorting Test in the number of errors,error numbers and classification numbers significant(P＜0.05).Conclusion GULP1 gene SNPrs2004888 polymorphism was associated with schizophrenia,and also related to cognitive function in schizophrenia.