Background:Studies have shown that patients with peptic ulcer are susceptible to the accompanying of anxiety and depression,and affects the treatment of ulcer. Aims:To study the effect of flupentixol and melitracen combined with quadruple therapy on peptic ulcer patients with anxiety and depression. Methods:Sixty-eight peptic ulcer patients with anxiety and depression from May 2012 to May 2013 at Wuhu No. 2 People’s Hospital were enrolled,and were randomly divided into control group and observation group. Patients in control group were given quadruple therapy( rabeprazole 20 mg + amoxicillin 1. 0 g + clarithromycin 0. 5 g + colloidal bismuth subcitrate solution 10 mL,bid),while patients in observation group were given flupentixol and melitracen in addition to quadruple therapy,the treatment course were both for 2 weeks. Therapeutic efficacy of ulcer,Helicobacter pylori( Hp) eradication,therapeutic efficacy of anxiety and depression,incidence of adverse reaction and recurrence rate of ulcer within one year after treatment were compared between the two groups. Results:Compared with control group,the therapeutic efficacy of ulcer and Hp eradication in observation group were significantly increased(P < 0. 05),therapeutic efficacy of anxiety and depression was significantly increased(P < 0. 05),no significant difference in the incidence of adverse reaction was found between the two groups,and the recurrence rate of ulcer within one year was significantly decreased( P < 0. 05). Conclusions:Flupentixol and melitracen combined with quadruple therapy could significantly improve the therapeutic efficacy and effectively reduce the recurrence rate in peptic ulcer patients with anxiety and depression.