Objective:To develop a compound erythromycin nose drops,according to the pathology of rhinitis and characteristics of medicines.　Methods:This compound consists of two components:a solid component (capsule containing pulvis of erythromycin lactobionat) and a liquid component (the water solution of diphenhydramine hydrochloride and ephedrine hydrochloride). When using,you have only to put the collocystis to the liquid and sway to achieve thixotropy.　Results:This compound medicine mainly apply to acute and chronic as well as allergic rhinitis. A clinical observation of 180 cases showed an effective rate of 91.11% and a cure rate of 68.33% using this compound we developed. When observing another group of patients (totally 169 cases),an effective rate of 57.99% and a cure rate of 30.77% were achieved by using chloramphenicol and ephedrine nasal drops. The difference between this two medicines is notable.　Conclusion:The technique for preparing this compound medicine is simple and easy,the raw materials easy to get,and the price cheap. This preparation is effective in the treatment of rhinitis and worth popularizing.

Vascular cognitive impairment (VCI) is a large class of syndromes caused by cerebrovascular risk factors, clinical or asymptomatic cerebrovascular disease from mild cognitive impairment to dementia. Its incidence is increasing, however, its pathogenesis remains uncertain, and the effective therapeutic means are lacking, Therefore, all aspects of research are increasingly receiving attention. This article mainly reviews the advances in research on vascular cognitive impairment from the concept, typing, diagnosis, prevention and treatment.