MicroRNAs are a class of small(about 20-24 nueleotides),endogenous,noneoding RNA molecules that regulate a wide array of physiologic processes,such as growth and developmenL In recent years,some researches show that the tissues from tumors have aberrant mieroRNA profiling compared with normal tis-sues.The abnormal miemRNA profiling can affect the genesis,proliferation,differentiation,metastasis and recur-renee of tumors.The different expressions of microRNA Can not only help for the diagnosis of tumors,but also evaluate the prognosis of tumors.Disturbing several miemRNA expressions can decrease the volumes of tumor and inhibit the peritoneal metastasis 80 as to treat the tumor by using anti-mieroRNA drugs in animal expedments.

Delta-like ligand 4(Dll4), one ligand of Notch receptors, is highly expressed in tumour vessels and is negative regulator in tumour angiogenesis. Blocking Dll4/Notch sinaling could promote tumour angiogenesis, whereas due to poor perrusion of newly forming vessels, tumour growth is inhibited, which is effective even to the tumour patients unresponsive to blocking vascular endothelial growth factor pathway. So, Dll4 is becoming a new promising target in anti-tumour theraties.

Delta-like ligand 4 (D114), one ligand of Notch receptors, was highly expressed in turnout vessels and was a negative regulator in tumour angiogenesis. Blocking D114/Notch signaling could promote tnmour angiogen-esis, whereas due to poor peffnsion of newly forming vessels, tumour growth was inhibited, which was effective even to the tumour patients unresponsive to blocking VEGF pathway. So, D114 is becoming a new promising target in anti-tumour therapies.

Objective To investigate the effect of blood pressure when measuring with clothing. Methods Measure the blood pressure of the right upper limb by using two different methods among the same group, and then analyze the data. Results Both SBp and DBp values which have measured with clothing are significant higher than those which have measured without clothing. The average difference of SBp and DBp are 1.54 mm Hg and 1.01 mm Hg respectively. Conclusion The patients who have no abnormal Bp history can be measured Bp with clothing, while this method should be forbidden to the patients who have hypertension or hypotension history.

The metabolic syndrome is a complex disorder of several metabolic abnormalities,which represents a risk factor of type 2 diabetes mellitus and cardiovascular diseases.Insulin resistance seems to play a significant role in pathoyenesis of metabolic syndrome.Many issues concerning definition,pathophysiology and optimal treatment of metabolic syndrome are reviewed in this article.

Objective To detect bacterial content on surface of mobile phones of health care workers (HCWs)by adenosine triphosphate (ATP )bioluminescence assay.Methods HCWs in departments of internal medicine,surgery, medical laboratory,and administration were randomly selected,50 in each department,field detection on bacterial content on surface of mobile phones of HCWs was conducted,the relevant data were recorded.Results A total of 200 mobile phones were detected,33 mobile phone surface were qualified,the qualified rate was 16.50%.Qualified rate of mobile phone surface of HCWs in different departments as well as mobile phone disinfected by different modes were different(χ2 =13.46,10.24,respectively,both P <0.01);difference in qualified rate of mobile phones of different types,different service life,and different protective case were all not significant (χ2 =4.37,1 .87,0.25 respectively,all P >0.05).Conclusion The qualified rate of bacterial content on surface of HCWs’mobile phone is low,the awareness of hand hygiene of HCWs should be strengthened,regular cleaning and disinfection on the mo-bile phone can effectively reduce bacteria on the mobile phone surface.

0.05 ).Nitrogenous retentive rate,net nitrogenous utilizing rate and cumulative nitrogen balance were higher in Glamin group compared with those in Vamin group and Novamin group( P

Objective To investigate healthcare-associated infection(HAI)prevalence and antimicrobial use in a hospital.Methods HAI prevalence rate,antimicrobial use and pathogen detection in all inpatients on August 21 , 2013 were investigated with cross-sectional survey method.Results A total of 2 238 inpatients were investigated, 104 patients developed 126 times of HAI,HAI prevalence rate and case rate was 4.65% and 5.63% respectively;the top four sites for HAI were lower respiratory tract (28.57%),upper respiratory tract(18.25%),urinary tract (7.94%)and gastrointestinal tract(4.76%).Rate of specimens delivered for detection was 91 .35%(95/104),the main specimen was sputum (26.32%),followed by blood (25.26%)and urine (10.53%).Antimicrobial usage rate was 24.58%,therapeutic,prophylactic plus therapeutic,and prophylactic use accounted for 36.55%,45.09%, and 18.36% respectively;the usage rate of single,combination of 2,and 3 antimicrobial agents accounted for 75.82%,20.91 % and 3.27% respectively.Risk factors of HAI were age (<15 or >60 years),all kinds of inva-sive procedures (tracheotomy,mechanical ventilation,urinary catheterization,arteriovenous intubation,hemodialy-sis),and anti-tumor chemotherapy.Conclusion Survey on HIA prevalence helps to know the occurrence of HAI and usage of antimicrobial agents,as well as risk factors and high-risk departments of the occurrence of HAI,it also provides basis for subsequent targeted monitor on HAI.

Objective: To study the effect of low fat diet on expression of protein kinase B (PKB) in adipose tissue of rats with insulin resistance. Method: Thirty male Wistar rats were randomly divided into control group ( C, n=10),given low fat diet; model group (M, n=20), given high fat diet. After 4 w, group M was randomly divided into 2 subgroups accepting diet intervention of 6 w.(1)High fat group (HF) was continually given high fat diet;(2)Low fat group (LF) accepted low fat diet. The expression of PKB stimulated by insulin in adipose tissue was determined with Western blotting at the end of the experiment. Results: (1) Group M showed hyperglycemia, hyperinsulinism, hypertriglyceride, hypercholesterolemia and elevated HOMA insulin resistance index (HOMA-IR) while the insulin sensitivity index (ISI) was obviously reduced compared to group C, indicating that the insulin resistant model was induced ; (2) Low fat diet treatment decreased FBG,TG,TC,which were accompanied by lower HOMA-IR and elevated ISI; (3) Because of long term high fat diet, expression of PKB in adipose tissue of group HF decreased by 23.5% (P

Objective:To compare the effects of distal movement of canines between elastic traction and canine lace back in the aligning stage of preadjusted appliance. Methods:50 cases with Angle I malocclusion were divided into two groups after first premolar extraction. Patients in both groups were treated by the same kind of preadjusted appliance in the aligning stage. Canine lace back was used in one group and elastic traction in another.Treatment was countinued for 12 weeks.Measurements of the dental models and the cephalograms were conducted before and after treatment.Results:Compared to the canine lace back, the decrease of the width between the cuspids of upper premolars and that between that of lower molars, the increase of the angle of the distally tipped canines and the mesially tipped lower molars and the lingually tipped incisors, the higher speed and larger distance of distal moving canines were achieved more easy with elastic traction. On the contrary, the larger distance of mesial moving molars were attained with canine lace back. The differences of all the measurements above between the two methods were significant(P