1.TOXIC EFFECT OF LIDOCAINE ON THE ACUTE ISCHEMIC HEART OF RABBIT AND THE ANTAGONISTIC ACTION OF L-4-THIAZOLIDINE CARBOXYLIC ACID
Xiaomin YANG ; Dehua ZHAO ; Baoheng SHENG
Medical Journal of Chinese People's Liberation Army 1983;0(02):-
This paper reported that lidocaine given intravenously 5mg/kg 9 min before occlusion of left ventricular coronary artery (CO) may shorten the latent period for ventricular arrhythmias from 6.2?1.9 min to 3.7?0.9 min (P
2.THE EXPERIMENTAL ANTI-ARRHYTHMIC EFFECTS OF l-STEPHOLIDINE
Dehua ZHAO ; Guangdong ZHAO ; Baoheng SHENG
Chinese Pharmacological Bulletin 1987;0(01):-
Intravenous injection of SPD 10 mg/kg could increase the tolerant dose of ouabain, and prevent the arrhythmias induced by acute myo-cardial ischemia in rats and that elicited by adrenaline-chloroform model in rabbits. SPD 60 mg/kg intraperitoneally could abolish the ventricular fibrillation produced by chloroform inhalation in mice. It inhibited the contractility, prolonged the functional refractory period and decreased the automaticity significantly of the isolated guinea pig papillary muscles, but no significant effect on excitability.
3.EFFECTS OF NICORANDIL ON PHYSIOLOGICAL PROPERTIES OF GUINEA PIG PAPILLARY MUSCLES
Dehua ZHAO ; Shuiying CHEN ; Kunquan FANG ; Baoheng SHENG
Chinese Pharmacological Bulletin 1987;0(02):-
The effects of nicorandil ( NICO ) on the contractility, automati -city, excitability, functional refractory period ( FRP ) & dose-response curves for isoprenaline as well as calcium were studied in guinea pig papillary muscles. NICO could decrease the amplitude of contraction of papillary muscles dose-dependently. Propranolol and NICO might antagonize the inotropic effect of isoprenallne. Verapamil & NICO induced Ca2+ antagonistic effects in a non-competitive manner, & the maximal Ca2+ response of papillary muscles decreased signifi- cantly. The automaticity of papillary muscles was decreased Significantly when the concentration of NICO reached 1.4 mmol/L, but exerted no effect on their excitability & the functional refractory period.