A patient with basidiobolomycosis is reported,the clinical course described,the ultra- structural and histologic changes observed,and mycologic examination was made.The results indicated that:(1)In the course of using corticosteroids,because the inflammatory reaction was suppressed par- tially,the clinical manifestation was relatively relieved.In the loci the pathogenic fungi still grew well, and focal dissemination was observed;(2) In the course of using itraconazole,the drug exerted fungistatic and fungicidal action through the destruction of cell membranes of fungi.Meanwhile,itra- conazole also exerted a synergistic action with the defense function of the human body,resulting in an enhanced therapeutic effects.The strong acute inflammatory reaction was triggered by the destroyed fungi caused by itraconazole.Then the fungi were cleared,the lesions were absorbed and repaired.Sur- gical intervention may be helpful to remove abscesses and fibrous nodules formed in the clinical course, so as to shorten the course of treatment.

Objective The current study was designed to investigate the inhibitive effect of celastrol on the proliferation of acute myelogenous leukemia (AML) cells. Methods The effect of celastrol on AML cells in vitro was examined by MTT assay and flow cytometry (FCM). Results After the AML primary cells were treated with different concentrations of celastrol, the results were analyzed by MTT. The growth of the cells were significantly inhibited compared with the control group (P ＜0.01). The results detected by FCM showed that the apoptosis was seen after treated with celastrol with different concentration for different times.The apoptotic rates were significantly higher than that in the control group with statistical significance (P＜ 0.01).Conclusion Celastrol could inhibit the proliferation of AML cells in vitro, which may be associated with inducing cell apoptosis.