2.Safety evaluation of Chinese medicine on tumor therapy.
Rui LIU ; Bao-Jin HUA ; Jie LI
China Journal of Chinese Materia Medica 2013;38(23):4181-4184
As a characteristic tumor therapy in China, Chinese medicine (CM) plays an important position in comprehensive treatment of tumor. It's a critical issue of objective realization, analysis and evaluation of CM safety for scientific decision-making in tumor safe medication and it also is a pivotal issue which affects the international communication. The safety evaluation of CM includes three phases: pre-clinical safety evaluation, clinical trials (micro-dose studies and traditional clinical trials) and post-marketing CM safety assessment. The key point of evaluation should be distinguished among different stages and various types of CM (such as classic formulas, Chinese herbal extracts, etc). Emphasis should be given to chronic toxicity when evaluating oral Chinese herbal , microdose studies and quality control must be underlined while injection is evaluated and more attention should be pay to the dose-effect relationship and time-effect relationship when turned to toxic Chinese medicine , and so as for the toxicity grading study. Moreover, we should constantly improve CM safety assessment method in various stages of tumor treatment, such as introducing the concept of syndrome classification theory, bringing in metabonomics and real-world research method which are similar to the CM therapeutic concept. Most importantly, we must keep its own feature of CM theory when we learn the concept of safety evaluation from abroad. Actively exploring the anti-tumor medicine safety evaluation methods and strategies is of great significance for clinical and experimental research, and it can provide supportability platform to CM's international communication.
Animals
;
Combined Modality Therapy
;
Humans
;
Medicine, Chinese Traditional
;
adverse effects
;
methods
;
Neoplasms
;
therapy
;
Safety
5.Effects of postpartum lactation of puerperal women with qi and blood deficiency treated by catgut embedding therapy.
Li-Ping LI ; Ye-Hua BAO ; Jia-Mei CHU
Chinese Acupuncture & Moxibustion 2014;34(2):189-190
Acupuncture Therapy
;
Adult
;
Catgut
;
utilization
;
Female
;
Humans
;
Lactation
;
Lactation Disorders
;
physiopathology
;
therapy
;
Postpartum Period
;
physiology
;
Qi
;
Young Adult
6.Correlation of asthma susceptibility gene polymorphisms with API positive infantile wheezing
Hong CHEN ; Haipei LIU ; Yixiao BAO ; Li HUA
Journal of Clinical Pediatrics 2013;(6):547-550
10.3969/j.issn.1000-3606.2013.06.014
7.Relationship of urinary ttMA, S-PMA and 8-OHdG in workers to low-level BTEX.
Ren-ping LIU ; Jian-hua ZHOU ; Bao-li ZHU
Chinese Journal of Industrial Hygiene and Occupational Diseases 2012;30(12):918-922
Acetylcysteine
;
analogs & derivatives
;
urine
;
Adolescent
;
Adult
;
Deoxyguanosine
;
analogs & derivatives
;
urine
;
Female
;
Furans
;
urine
;
Humans
;
Hydrocarbons, Aromatic
;
analysis
;
Male
;
Occupational Exposure
;
analysis
;
Young Adult
8.Association of single nucleotide polymorphisms in RANTES and Eotaxin-3 genes with childhood asthma
Jing HUO ; Quanhua LIU ; Li HUA ; Yixiao BAO
Journal of Shanghai Jiaotong University(medical Science) 2010;30(2):129-131
Objective To investigate the association of single nucleotide polymorphisms(SNPs)in regulated upon activation normal T cell expressed and secreted (RANTES) gene C-28G(RANTES C-28G),RANTES A-403G and Eotaxin-3 gene C +77T(Eotaxin-3 C+77T) with asthma in Han ethnic children. Methods The buccal mucosa swabs of 192 Han ethnic children with asthma (asthma group) were collected,and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was employed to detect the SNP loci of RANTES A-403G,C-28G and Eotaxin-3 C+77T.Besides,another 192 healthy subjects (aged 18 to 22 years) without sibship with those in asthma group were served as controls.Genotype and genotypic distribution between these two groups were analysed. Results There was no significant differences in genotype and genotypic distribution of SNP loci of RANTES A-403G and RANTES C-28G between asthma group and control group (P>0.05),while there were significant differences in genotypic distribution of Eotaxin-3 C+77T between these two groups.The frequency of Eotaxin-3 C+77T T/T genotype in asthma group was significantly higher than that in control group (32.3% vs 12.5%,OR=3.44,P=0.000). Conclusion Eotaxin-3 C+77T may be the asthma susceptible SNP loci for Han ethnic children,and Eotaxin-3 C+77T T/T is significantly related with the development of childhood asthma
10.Research progress in the study of protective effect of tanshinone IIA on cerebral ischemic stroke.
De-chuan LI ; Xiu-qi BAO ; Hua SUN ; Dan ZHANG
Acta Pharmaceutica Sinica 2015;50(6):635-639
Danshen is one of the traditional Chinese herbal medicines and nas a long history or being used clinically in the treatment of cardiovascular and cerebrovascular conditions such as coronary heart disease and angina pectoris. Tanshinone IIA is a derivative of phenanthrene-quinone isolated from Danshen. It has been reported to be the major bioactive compound of Danshen and has diverse biological effects. Recent studies demonstrated that tanshinone IIA had neuroprotective effects on experimental ischemic stroke through its antiinflammatory, anti-oxidant, anti-apoptosis effects and its inhibitory effect on excitatory amino acid toxicity. In this review, we summarized all the recent progresses on the protective effect of tanshinone IIA on cerebral ischemic stroke. Hopefully, this article will throw some light on further study and application of tanshinone IIA.
Antioxidants
;
therapeutic use
;
Apoptosis
;
Diterpenes, Abietane
;
therapeutic use
;
Drugs, Chinese Herbal
;
therapeutic use
;
Humans
;
Salvia miltiorrhiza
;
chemistry
;
Stroke
;
drug therapy