1.Video-assisted thoracoscopic surgery in the prone position for esophageal carcinoma
Yulong HOU ; Jianqiang ZHAO ; Wei GUO ; Bao ZANG ; Derong TANG
Chinese Journal of General Practitioners 2012;11(3):224-226
Forty one patients with esophageal carcinoma (T3N1 M0 or less) underwent video-assisted thoracoscopic surgery (VATS) in prone position for esophagectomy from September 2006 to September 2010.The postoperative outcome and survival of patients were retrospectively analyzed.The results confirmed the feasibility and safety of this minimally invasive esophagectomy performed by thoracoscopy in the prone position for patients with esophageal carcinoma.
2.Preparation and evaluation of Shedan in situ forming gel based on ocular characteristics.
Guo-hua WANG ; Qi-xia NIE ; Chen ZANG ; Bao-xian ZHANG ; Qiong ZHU
China Journal of Chinese Materia Medica 2015;40(15):2982-2987
To develop an ophthalmic preparation of Shedan, an in situ forming gel was prepared with the formulation containing 18% of poloxamer 407 and 5% of poloxamer 188 by response surface designs plus central composite designs. The rheology results showed that LVE range gamma should limited within 0.5%, Shedan high-frequency region, and the thixotropy recovery time is less than 5 seconds. The phase transition temperature was 33.25 °C according to curve of storage modulus and loss modulus determined by temperature scanning. Surface tension and osmometer of it determined by surface tension meter and dew point osmometer were 36.43 mN · m(-1), and 320.6 mOsm · kg(-1), respectively. Fluorescein sodium was selected as the marker to monitor the corneal residence time, and the results showed that Shedan gel could prolong drug residence for 180 min. In line with zero-order kinetics, releases of muscone and salvianolic acid B in vitro depends on gels erosion. The results of rabbit ocular irritation experiments suggested that Shedan in situ forming gel was biocompatible and nonirritant. In conclusion, a novel Shedan in situ forming gel was developed and characterized for potential drug treatment of retinal vein occlusion.
Animals
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Benzofurans
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chemistry
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Cycloparaffins
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chemistry
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Female
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Gels
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chemistry
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Male
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Ophthalmic Solutions
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Poloxamer
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chemistry
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Rabbits
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Retinal Vein Occlusion
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drug therapy
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Viscosity
3.Neuroprotective and mechanistic study of GJ-4 on okadaic acid-induced memory impairment in mice
Yang YANG ; Chan-juan SHENG ; Cai-xia ZANG ; Jun-mei SHANG ; Xiu-qi BAO ; Dan ZHANG
Acta Pharmaceutica Sinica 2023;57(12):3628-3636
GJ-4 is crocin enrichments extracted from
4.Preventive and therapeutic effects of xiaobanxia fuling decoction on cisplatin-induced pica rats.
Chun-bao ZANG ; Hu MA ; Yu-ju BAI
Chinese Journal of Integrated Traditional and Western Medicine 2011;31(10):1414-1418
OBJECTIVETo investigate the preventive and therapeutic effects of Xiaobanxia Fuling Decoction (XBFD) on cisplatin-induced pica rats and to study its mechanism.
METHODSForty-two male Sprague-Dawley rats were randomly divided into the following 7 groups, i.e., the blank control group, the model group, the high-, middle-, and low-dose XBFD groups (at the daily dose of 30, 15, and 7. 5 g/kg, respectively), the aprepitant (at the daily dose of 13 mg/kg), and pure Chinese medicine group (at the daily dose of XBFD 15 g/kg), 6 in each group. On the 3rd day of this study, 3 mg/kg cisplatin was intraperitoneally injected to rats except the blank control group and the model group to establish the pica rat model. The consumptions of kaolin, food, and the general situation of rats were observed. The protein and mRNA expressions of neurokinin 1 receptor (NK1R) in both the medulla oblongata and the gastric antrum were measured by immunohistochemical assay and Real-time fluorescent quantitative PCR respectively on the sixth day of this study.
RESULTSOn the third, fourth, and fifth day of this study, the consumption of kaolin of rats significantly increased when compared with the blank control group (P<0.01). Compared with the model group, the consumption of kaolin significantly decreased in the high-, middle-, and low-dose XBFD groups on the third, fourth, and fifth day of this study (P<0.05). The food intake of rats in the high-dose XBFD groups significantly increased when compared with the model group on the third day of this study (P<0.05). The protein and mRNA expressions of NK, R in the medulla oblongata and the gastric antrum significantly decreased in the high- and middle-dose XBFD groups when compared with the model group (P<0.05).
CONCLUSIONSXBFD could prevent and treat cisplatin-induced pica in rats. Its effect might be correlated with decreasing expressions of NK, R in the medulla oblongata and the gastric antrum.
Animals ; Cisplatin ; adverse effects ; Drugs, Chinese Herbal ; therapeutic use ; Male ; Pica ; chemically induced ; drug therapy ; prevention & control ; RNA, Messenger ; genetics ; Rats ; Rats, Sprague-Dawley ; Receptors, Neurokinin-1 ; metabolism
5.Influence of soft capsule of compound oil of jujube, arborvitae and gardenia on learning and memory, and brain NO, Ach content of castrated rats.
Bao-Li LI ; Zhao-Ying FU ; Ya-Hui CHEN ; Feng GAO ; Zheng-Xiang ZANG
Chinese Journal of Applied Physiology 2012;28(5):403-424
Acetylcholine
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metabolism
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Animals
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Brain
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drug effects
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metabolism
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Female
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Gardenia
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chemistry
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Maze Learning
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drug effects
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Nitric Oxide
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metabolism
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Ovariectomy
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Plant Extracts
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pharmacology
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Rats
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Thuja
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chemistry
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Ziziphus
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chemistry
6.Study on the effect of mild moxibustion combined with cupping therapy on serum creatine kinase in gym-athletes.
De-li SUN ; A-bao ZANG ; Ming XU ; Zhi-jun LI ; Xun-sheng ZHU ; Yan ZANG ; Da-long CHEN ; He-xin JIANG ; Yi SONG ; Wang-shen HAO
Chinese Acupuncture & Moxibustion 2007;27(1):6-8
OBJECTIVETo probe into eliminating action of mild moxibustion combined with cupping therapy on athletic fatigue.
METHODSObserve changes of serum creatine kinase activity in gym-athletes with once great intensity training or periodic great intensity training, and the interfering effect of mild moxibustion combined with cupping therapy.
RESULTSThe mild moxibustion combined with cupping therapy has a significant promoting action on recovery of the increased serum creatine kinase activity induced by once great intensity training or periodic great intensity training in gym-athletes.
CONCLUSIONThe method has a better action of eliminating athletic fatigue.
Acupuncture Points ; Adolescent ; Child ; Creatine Kinase ; blood ; Female ; Gymnastics ; Humans ; Male ; Medicine, Chinese Traditional ; Moxibustion
7.Studies on preparation technology of Flos Magnoliae essential oil-beta-cyclodextrin inclusion complex.
Qi-xia NIE ; Xiao-mei ZHAO ; Chen ZANG ; Bao-xian ZHANG ; Qing-ran FENG
China Journal of Chinese Materia Medica 2003;28(6):507-508
OBJECTIVETo find the best condition of the preparation technology of Flos Magnoliae essential oil-beta-cyclodextrin inclusion complex.
METHODL9(3(4)) table was used to examine the effects of 4 factors, and the inclusion rate of each test was determined of orthogonal test.
RESULTThe best condition was:oil:beta-cyclodextrin:water = 1:8:60 (mL:g:mL), stirring for 1 hour at 80 degrees C.
CONCLUSIONThe complex prepared on the condition aforementioned is stable and stirring has a highest inclusion rate.
Cyclodextrins ; Drug Carriers ; Drug Stability ; Drugs, Chinese Herbal ; administration & dosage ; isolation & purification ; Flowers ; chemistry ; Magnolia ; chemistry ; Oils, Volatile ; administration & dosage ; isolation & purification ; Plants, Medicinal ; chemistry ; Technology, Pharmaceutical ; methods ; beta-Cyclodextrins
8.Research progress of ursolic acid's anti-tumor actions.
Li-li ZANG ; Bao-ning WU ; Yuan LIN ; Jun WANG ; Lei FU ; Ze-yao TANG
Chinese journal of integrative medicine 2014;20(1):72-79
Ursolic acid (UA) is a sort of pentacyclic triterpenoid carboxylic acid purified from natural plant. UA has a series of biological effects such as sedative, anti-inflammatory, anti-bacterial, anti-diabetic, antiulcer, etc. It is discovered that UA has a broad-spectrum anti-tumor effect in recent years, which has attracted more and more scholars' attention. This review explained anti-tumor actions of UA, including (1) the protection of cells' DNA from different damages; (2) the anti-tumor cell proliferation by the inhibition of epidermal growth factor receptor/mitogen-activated protein kinase signal or of FoxM1 transcription factors, respectively; (3) antiangiogenesis, (4) the immunological surveillance to tumors; (5) the inhibition of tumor cell migration and invasion; (6) the effect of UA on caspase, cytochromes C, nuclear factor kappa B, cyclooxygenase, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or mammalian target of rapamycin signal to induce tumor cell apoptosis respectively, and etc. Moreover, UA has selective toxicity to tumor cells, basically no effect on normal cells. With further studies, UA would be one of the potential anti-tumor agents.
Angiogenesis Inhibitors
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pharmacology
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therapeutic use
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Animals
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Antineoplastic Agents, Phytogenic
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chemistry
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pharmacology
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therapeutic use
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Apoptosis
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drug effects
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Humans
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Immunologic Surveillance
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drug effects
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Neoplasms
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blood supply
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drug therapy
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immunology
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pathology
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Triterpenes
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chemistry
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pharmacology
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therapeutic use
9.Application of Microwave Drying and Sterilization Technology in TCM Field
Shuang WANG ; xia Qi NIE ; xian Bao ZHANG ; yan Li ZHANG ; Chen ZANG ; hua Guo WANG ; Yue SHANG
Chinese Journal of Information on Traditional Chinese Medicine 2017;24(11):132-136
Compared with traditional drying methods for Chinese materia medica, microwave drying technology is not only with the features of easy and convenient to operate, rapidity, good effects, well remained appearance of medicine and low energy consumption, but also with the feature of extraordinary sterilization effects at the same time with drying. This article introduced the features and effects of microwave drying and sterilization technology, reviewed its application in the TCM field, and proposed existing problems and prospects in the recent research by targeting security problems (microwave radiation and microwave residue).
10.Antagonistic effect of hydroxysafflor yellow A on the platelet activating factor receptor.
Bao-xia ZANG ; Ming JIN ; Nan SI ; Yan ZHANG ; Wei WU ; Yong-zhe PIAO
Acta Pharmaceutica Sinica 2002;37(9):696-699
AIMTo observe the antagonistic effect of hydroxysafflor yellow A (HSYA) on the platelet activating factor (PAF).
METHODSWashed rabbit platelet (WRP) aggregation and rabbit polymorphonuclear leukocytes (PMNs) aggregation induced by PAF were observed by turbidimetric assay in vitro. The PAF receptor antagonistic effect of HSYA was investigated by radio ligand binding assay (RLBA).
RESULTSIn RLBA the specific binding inhibition effect of HSYA was found to be concentration-dependent in three different [3H]PAF concentrations. In the experiments, WRP aggregation and rabbit PMNs aggregation induced by PAF (9.55 x 10(-10), 9.55 x 10(-6) mol.L-1) were both inhibited by HSYA in a concentration-dependent manner in vitro. The IC50 of HSYA to inhibit WRP and rabbit PMNs aggregation was 0.99 and 0.70 mmol.L-1, respectively.
CONCLUSIONThe PAF receptor binding can be antagonized by HSYA.
Animals ; Carthamus ; chemistry ; Cell Aggregation ; drug effects ; Chalcone ; analogs & derivatives ; isolation & purification ; pharmacology ; In Vitro Techniques ; Male ; Neutrophils ; drug effects ; Plants, Medicinal ; chemistry ; Platelet Aggregation ; drug effects ; Platelet Membrane Glycoproteins ; antagonists & inhibitors ; Quinones ; isolation & purification ; pharmacology ; Rabbits ; Receptors, G-Protein-Coupled ; antagonists & inhibitors