Insulinoma (islet β-cell tumor) is one of the most common pancreatic endocrine tumors. It has a typical clinical manifestation called Whipple's triad. And so far, surgical treatment is the only curative method. But the localization diagnosis of insulinoma is difficult. Recently, with advances in diagnostic tech-niques, the localization diagnosis of insulinoma accuracy has markedly improved. This paper makes a brief overview of the progress in diagnosis and treatment of insulinoma.

Objective To detect serum concentrations of Dickkopf-1(DKK-1) and soluble receptor activator of nuclear factor-κB ligand (sRANKL) in patients with multiple myeloma (MM) and to investigate its clinical significance. Methods Serum DKK-1, sRANKL, osteoporotegerin(OPG) and tartrate-resistant acid phosphatase 5b (TRACP-5b) levels were quantified in 30 newly diagnosed MM patients and 20 healthy control subjects by using sandwich ELISA. Results The serum DKK-1, sRANKL,OPG and TRACP-5b levels were significantly higher than those in the healthy controls (42.96 μg/L vs 5.33 μg/L, 1.83 pmol/Lvs 0. 79 pmol/L, 1799. 30 pmol/L vs 822.40 pmol/L, 5.81 U/L vs 0. 28 U/L, respectively; all P＜0. 05). Serum levels of DKK-1 were positively correlated with sRANKL and TRACP-5b, respectively.Serum concentrations of DKK-1 and sRANKL were significantly elevated in stage Ⅲvs stages Ⅰ and Ⅱaccording to International Staging System (ISS) (46. 33 μg/L vs 37.91 μg/L, 2.26 pmol/L vs 1.19pmol/L, respectively, all P ＜0.05). Serum concentrations of DKK-1 , sRANKL and TRACP-5b were significantly higher in patients with more than 3 lytic bone lesions than those with only 1-3 lytic bone lesions (46. 30 μg/L vs 31.98 μg/L, 2. 18 pmol/L vs 0. 69 pmol/L, 6.02 U/L vs 5. 13 U/L, all P ＜ 0.05).Conclusions MM patients have increased serum DKK-1, sRANKL, OPG and TRACP-5b levels as compared with the healthy controls. Serum concentrations of DKK-1 and sRANKL have close relationship with MM stage and lytic bone disease.

The effects of carbon source, Sodium glutamate, salinity, and incubation temperature on the growth of Thraustochytrium aureum H0 and the production of docosahexaenoic acid were studied. The time course of the cell growth of Thraustochytrium aureum H0 was determined. The results showed that glucose is the best carbon souce and the optimum concentrations of glucose and Sodium glutamate are 30g ? L-1 and 5g ? L-1 respectively. The suitable salinity is half of salinity of sea water. Under the optimum culture conditions, 6. 2g ? L-1 of the dry cell weight and 0. 51g ? L-1 of the docosahexaenoic acid were obtained.

One cases of vertically fractured molar was treated by following methods:the gap was exparded,the furcation lesion was drained;then a fixed prosthesis was inserted to restore the affected area.No symptom was observed in 2-year follow-up.

Objective To study the expression of CD105 and CD31 and relationship with the biological behavior in gastric cancer tissue. Methods Immunochemical method was adopted to detect the microvessel density(MVD) of CD105 and CD31 in 63 cases of gastric cancer and 20 cases of chronic gastritis. Results The mean value of CD105-MVD and CD31-MVD were respectively 40.97?15.67 and 25.87?10.54 in gastric cancer, which was higher than those in chronic gastritis, the difference was significant (P 0.05). Conclusion CD105 was better than CD31 in staining gastric cancer tissue. Expression of CD105 was closely related to the biological behavior of gastric cancer; detection of CD105 was recommended to precisely assess tumor stage, direct cancer therapy and predict prognosis.

Anemia, Refractory, with Excess of Blasts ; complications ; drug therapy ; Azacitidine ; analogs & derivatives ; therapeutic use ; Humans ; Male ; Middle Aged ; Myelodysplastic Syndromes ; complications ; drug therapy ; Treatment Outcome

[Objective] To study the effect of family sickbed comprehensive nursing mode on patients with stroke.[Methods] 92 cases of discharged patients with cerebral apoplexy were selected between October 2010 and October 2011,and were divided into the observation group(52 cases)and the control group(40 cases).Among them,the observation group received the family sickbed comprehensive nursing intervention,which was conducted by community nurses.The control group received general discharge mode and did not accept community nursing intervention.As designed,patients were followed weekly or monthly after discharge.After three months the treatment efficacy and quality of life were assessed.[Results] After follow-up for 3 months,HAMD,NIHSS scores in the intervention group were lower than those of the control group,MMSE,FMA and BI scores were higher than those of the control group.The physical,psychological,social and environmental scorcs in the intervention group were higher than those in the control group.[Conclusions] Family sickbed comprehensive nursing of cerebral apoplexy patients during rehabilitation stage can not only save medical resources,but also facilitate to recovery of patients.

Child ; Congresses as Topic ; Coronary Disease ; diagnosis ; etiology ; therapy ; Humans ; Immunoglobulins, Intravenous ; administration & dosage ; therapeutic use ; Incidence ; Injections, Intravenous ; International Cooperation ; Mucocutaneous Lymph Node Syndrome ; epidemiology ; etiology ; therapy

American Heart Association ; Anti-Bacterial Agents ; administration & dosage ; therapeutic use ; Cardiac Surgical Procedures ; Child ; Drug Resistance, Bacterial ; Drug Therapy, Combination ; Endocarditis ; drug therapy ; surgery ; Endocarditis, Bacterial ; drug therapy ; surgery ; Humans ; Practice Guidelines as Topic ; United States

Objective To discuss the effect of Ginsenoside-Rg combined with oxaliplatin and sorafenib on hepatic carcinoma cell apoptosis. Method Ginsenoside-Rg, oxaliplatin and sorafenib were divided into single drug group, two drugs group and three drugs group to act on hepatic carcinoma cell. Multiplication, prophase apoptosis, middle and advanced stage apoptosis were observed. Results To combine three drugs could improve hepatic carcinoma cell inhibition ratio, apoptosis ratio, apoptotic index compared to those of two drugs group or single drugs group(P<0.01). Conclusion To combine Ginsenoside-Rg, oxaliplatin and sorafenib can improve hepatic carcinoma cell inhibition ratio.