Objective To investigate the operation timing and operative procedure for serious acute pancreatitis(SAP).Method To analyze retrospectively the clinic data of 56 cases treated by operation.Result 54 cases were cured,who treated by operation within 48h after SAP onset. All the 2 cases dead of multiple organs failure who underwent operation 5-6d after SAP onset.Conclusions When SAP advanced to have indications of operative treatment,an-operation should be done as early as possible, no metter the time from the onset of SAP is long or short.