1.Prevalence, associated risk factors and antibiotic resistance pattern of bacterial uropathogens among pregnant women in a tertiary care hospital of Bangladesh
Sohana Al Sanjee ; Masudur Rahman ; Md. Ekramul Karim ; Umme Salma Sigma
Malaysian Journal of Microbiology 2020;16(4):294-301
Aims:
The study was designed to determine the prevalence of urinary tract infection (UTI) in pregnant women
depending on their various clinical and socio-demographic factors, and to assess the antibiotic susceptibility pattern of
the responsible uropathogens in a tertiary care hospital of Dhaka, Bangladesh.
Methodology and results:
A total of 100 midstream urine samples were collected from pregnant women and different
clinical and socio-demographic variables viz. age, gestational weeks, living conditions, and level of education associated
with UTI were determined. Bacterial isolation was carried out using blood and MacConkey agar and identified according
to their phenotypic characteristics. Antibiogram profiling of the isolates was done by disc diffusion method. From 48% of
positive UTI samples, the highest bacteriuria was recorded within the age group of 26-30 years (n=19; 59.38%) and in
both, 1st and 3rd trimester period (50%). There was no significant association between the studied risk factors and
bacteriuria, except for the age of the pregnant women. Most predominantly isolated bacteria was Escherichia coli (n=39;
81.25%), followed by Klebsiella pneumoniae (n=9; 18.75%). In E. coli, the highest resistance was recorded against
ceftriaxone (87.18%), followed by cephalexin (84.61%) and ceftazidime (79.49%); whereas K. pneumoniae showed
100% resistance to ceftriaxone and cephalexin. Netilmicin was found as the only effective antibiotic against E. coli
showing 100% sensitivity. For K. pneumoniae, azithromycin, imipenem, chloramphenicol, gentamicin, ciprofloxacin,
amikacin and nitrofurantoin were found as the most efficacious drugs.
Conclusion, significance and impact of study
As the emergence of drug resistance is ever increasing, the study
necessitates the continuous surveillance of antibiotic susceptibility of uropathogens to ensure safety and better
treatment to the mother and fetus.
Urinary Tract Infections--microbiology
;
Drug Resistance, Microbial
;
Pregnant Women
;
Bangladesh (Daka)