Objective To investigate the effect of compound Shuanghua tablets combined with western medicine on serum secretions TNF-α,IL-6 and IL-10 of patients with secretory otitis media.Methods A total of 200 cases(244 ears) with acute secretory otitis media in Zhejiang Xinchang People’s Hospital from August 2014 to June 2016 were randomly divided into two groups.The control group with 100 case (120ears) were only given conventional western medicine therapy,and the treatment group with 100 case (124ears) were given compound Shuanghua tablets on the basis of the control group.Peripheral venous blood and middle ear effusion of each patient was collected before and after treatment ,and to detect the level of TNF-α, IL-6 and IL-10 by cytometric bead array,meanwhile the curative effect of the two groups were compared.Results The curative effect of the treatment group( 97.58%) was higher than the control group(85.00%),the difference were statistically significant(P<0.05).There were no significant difference on serum TNF-α,IL-6 and IL-10 between the two groups before and after treatment.The secretions TNF-α,IL-6 and IL-10 of the two groups after treatment were significantly reducing,and the treatment group were lower than the control group,the difference were statistically significant (P<0.05).Conclusion Compound Shuanghua tablets combined with western medicine in traetment SOM is effective distinctly,and can reduce secretions TNF-α,IL-6 and IL-10 effectly.