Objective To examine the correlation of serum neutrophil gelatinase-associated lipocalin (NGAL) with dialysis adequacy,microinflammatory state and iron metabolism,and to assess the value of NGAL in identifying the dialysis adequacy in maintenance hemodialysis (MHD) patients.Methods A total of 150 MHD patients and 50 healthy control people were enrolled in the study.Clinical data were collected and serum NGAL,CRP,transferrin saturation,serum ferritin were measured.MHD patients were divided into adequacy group and non-adequacy group according to spKt/V value.Serum NGAL between two groups was compared and correlation of NGAL with spKt/V,inflammatory factors,and other clinical indexes was examined by Pearson,multivariate regression Logistic model and area under curve (AUC) of ROC.MHD patients were followed up for 3 months.Similar correlation analysis was carried out before and after follow up between two groups.Results Serum NGAL of MHD patients was higher compared to healthy people [(445.45±50.34) μg/L vs (50.02 ±6.45) μg/L].Among 150 MHD patients,95 were classified into adequacy group,while 55 into non-adequacy group according to spKt/V value.Serum NGAL was significantly higher in adequacy group as compared to non-adequacy group [(589.14±56.34) μg/L vs (360.13±46.23) μg/L,P＜0.05].Serum NGAL was positively correlated to spKt/V,CRP,TSAT [r=0.652,0.825,0.785,all P＜0.05],but not to serum ferritin.Serum NGAL was also correlated to spKt/V,CRP,TSAT by multivariate regression Logistic model.AUC showed that NGAL level could reflex the condition of dialysis adequacy.During the follow up,all adequacy patients remained the same adequacy status.Thirty-eight out of 55 non-adequacy patients were qualified for complete adequacy after intervention.The serum NGAL before and after intervention was (368.14±56.21) μg/L and (360.56±46.23) μg/L respectively without significant difference.Conclusions Serum NGAL is obviously higher in MHD patients with dialysis adequacy compared to those without dialysis adequacy.Serum NGAL is positively correlated to spKt/V,CRP,TSAT.NGAL can reflex the condition of dialysis adequate in MHD patients.

Objective To investigate the epidemiological features of infection among hemodialysis patients. Methods A total of 55 hemodialysis hospitalized patients diagnosed with infection were enrolled in this retrospective study from April 2010 to Augest 2013. Clinical date from 55 patients, were collected and analyzed with SPSS software. Results The 55 hemodialysis patients in 60 cases time got infected during the study, and the infection rate was 28.57%. Age, diabetes, hemoglobin were risk factors for infection. Pathogenic analysis showed 51.67% of infection was caused by gram-positive bacteria, 36.67% of infection was caused by gram-negative bacteria. The infection sites included vascu-lar access infection (43.33%) and lung infecton (48.33%). Drug sensitive tests showed that drug resistant rate of gram-positive bacteria to penicillin, ceftazidime, levofloxacin, streptomycin was high. There was no significance in the sea-sonal distribution of infection. Conclusion Infection rate is high in hemodialysis patients. Vascular access infection and lung infection are dominant infection sites.Drug resistance rate is high in infectious hemodialysis patients.