0.05). ② Significantly positive correlation was found between serum testosterone and fasting insulin (r=0.693, P

The pffect of 5 drugs on myocardial nutritional blood flow of micehave been determined with ~(86)Rb. It was shown that the root of xanthiumsibiricam, caesulpinia sepiaria and the branch of cinnamomum cassia couldincrease myocardial nutritional blood flow in mice The Pharmacologicalactions of these drugs have heen reviewed briefly.

Objective To assess whether lysyl oxidase like-2 (LOXL2) has a predictive or prognostic value in pulmonary fibrosis mice,and identify the relationship between LOXL2 and transforming growth factor (TGF)-β 1.Methods Male C57BL/6 mice (n=50) were randomly divided into the experimental group (n=40) and controls (n=10).Each mouse in the experimental group was induced by injecting bleomycin into trachea and mice were sacrificed on day 3,7,14 and 28,respectively.The concentrations of LOXL2,TGF-β 1 of the serum and lung homogenates were measured by enzyme-linked immunosorbent assay.One-factor analysis of variance (ANOVA) and nonparametric rank sum test was used for the comparisons between the two groups.Associations between these factors were analyzed by Spearman's test.Results ① The levels of serum and lung homogenates LOXL2 in the experimental group were obviously increased as compared to those in the controls [serum:(56±48) vs (25±23),P＜0.05;lung homogenates:(61±32) vs (22±16),P＜0.05].And in the experimental group,a positive correlation was found between the level of LOXL2 and the radiological index,the pathological score of inflammation and fibrosis.(Serum:r=0.435,0.533,0.335,P＜0.05;lung homogenates:0.675,0.736,0.526,P＜0.05).② The levels of lung homogenates TGF-β 1 in the experimental group were obviously increased as compared to those in the controls [(302±197) vs (64±16),P＜0.05].A positive correlation was found between the level of lung homogenates LOXL2 and the level of lung homogenates TGF-β1 (r=0.520,P＜0.05).Conclusion LOXL2 participates in the pathological process of bleomycin induced pulmonary fibrosis in mice.It predicts pulmonary fibrosis in the preclinical stage and is associated with increased risk for disease progression.The elevated levels of LOXL2 and TGF-β 1 may have some relationship.They both are involved in the disease progression of pulmonary fibrosis.

Objective To study the serum lipid(TC,TG,LDL-C) and the role of typeⅠcollagen,NF-?B,typeⅠcollagen mRNA and NF-?B mRNA levels and their mechanisms in the occurrence and progress of atherosclerosis in order to provide theoretical gist for its prevention.Methods Blood vessel wall pathological and the serum lipid changes,the expressions of typeⅠcollagen,NF-?B,typeⅠcollagen mRNA and NF-?B mRNA levels were observed in dietary induced atherosclerosis rabbit model by morphology study,immunohistochemistry,in situ hybridization technique and color image analyzer(CMAIS).Results The model of AS was established successfully after rabbits were fed with cholesterol,who developed the fatty streak lesion in the aortic intra-wall.In the rabbit model,TC and LDL were respectively increased 43 times and 37 times and there were no difference in TG and body weight.Type I collagen,NF-?B,type I collagen mRNA and NF-?B mRNA were 0.27?0.02,0.19?(0.01) and 0.30?0.03,0.35?0.03,respectively,which were higher than those of control group(0.08?0.01,0.09?0.01 and 0.11?0.01,0.10?0.09,respectively)(P

Adult ; Biomarkers, Tumor ; metabolism ; Epididymis ; metabolism ; pathology ; surgery ; Humans ; Inhibins ; metabolism ; Leydig Cell Tumor ; metabolism ; pathology ; surgery ; Male ; Testicular Neoplasms ; metabolism ; pathology ; surgery ; Vimentin ; metabolism

Objective To assess the clinical application value of ultrasound-guided aspiration biopsy in the diagnosis and differential diagnosis of cervical tumors.Methods Seventy-two patients with cervical tumors underwent ultrasonography and ultrasound-guided aspiration biopsy;and the obtained samples were examined histopathologically.Results The successful rate of aspiration biopsy was 98.15%,and the accurate rate of histopathological diagnosis was 97.22%.No complications occurred.Conclusion Being a minimally invasive,rapid,safe and simple method in diagnosis and differential diagnosis of cervical tumor,ultrasound-guided aspiration biopsy has important clinical value and can be used as the first choice of qualitative diagnosis of cervical tumor.

OBJECTIVE:To probe into a feasible work mode for special clinical pharmacist of hypertension.METHODS:Clinical pharmacists' works were summarized by considering the experience of clinical pharmacists and examples of pharmaceutical care in hypertension wards.RESULTS&CONCLUSIONS:Special pharmacists of hypertension should participate in clinical treatment team,check prescription every day and acquaintance with status quo of patients' medication so as to carry out pharmaceutical care suitability.It also should find out and resolve situation of ADR in time and master the characteristics of hypertension.

Objective:To correct the characterizations of MDCT radiation dose by exploring the relationship between CTDIw,∞ and CTDIw.Methods: CTDI100 and CTDI∞ were measured under the conditions of different collimations, pitches and tube voltages of Siemens Definition Flash CT, and CTDIw and CTDIw,∞ were calculated.Results: There were significant differences between CTDIw and CTDIw,∞ which were measured at 0.05 level. And there were no significant differences between CTDIw,∞ after corrected and CTDIw,∞ which were measured at 0.05 level.Conclusion:The characterizations of MDCT which were commonly used were not accurate enough. The result after correction were very closed to the real CTDIw,∞. This showed that the method to correct CTDIw of Siemens Definition Flash CT was mostly accurate. And methods to correct CTDIw of other MDCT needed to be further studied.

Objective: The purpose of the current study was to investigate the correction coefficient of the characterizations of multi-detector CT (MDCT). Methods: The dose profile of Siemens SOMATOM Definition Flash CT scanner was measured with CT-SD 16 detector under the conditions of different collimations, pitches and tube voltages in phantoms of different diameters, and the ratio between weighted CTDI∞and weighted CTDI100 was calculated. Results:The ratio between weighted CTDI∞and weighted CTDI100, which is growing for increasing beam collimation, was found to range from 1.123 to 1.162 in head phantom and range from 1.118 to 1.173 in body phantom. Conclusion: For MDCT, the use of CTDI100, which is one of the most commonly used characterizations of CT, has always underestimated the levels of radiation dose. Therefore, CTDI100 should be corrected.

Objective To collect information of patient doses of interventional radiology in Beijing Xuanwu Hospital,and investigate correlation between the peak skin dose(PSD) and dose-area product(DAP).Methods Radiation doses from 135 patients have been studied including 84 coronary angiographies(CAG) and 51 percutaneous transluminal coronary angioplasties(PCI).Dose-area product(DAP) values,cumulative dose(CD) at interventional reference points,fluoroscopy times,total number of cine frames were collected for each patient.Skin dose measurements were made with thermoluminescent dosimeters(TLD) placed as a 10 ? 9 arrays of TLDs on the body.The grid of TLDs arrays was 5 ? 4 cm.Results Mean values for dose-area product were 2690.84 ?Gym2 for CAG and 7946.91 ?Gym2 for PCI.Mean values for CD were 431.6 mGy cm2 for CAG and 1395.3 mGy for PCI.Mean fluoroscopy times were 2.9 min for CAG and 10.9 min for PCI and mean number of frames were 544 and 945 for CAG and PCI,respectively.PSD values ranged from 26.18 to 120.37 mGy for CAG and 38.91 to 184.79 mGy for PCI.The relationship between DAP and PSD was r = 0.52 for CAG and r = 0.54 for PCI.The correlation of PSD with CD was r = 0.45 for CAG and r = 0.53 for PCI.Conclusion Comparison shows that patients DAP,CD and fluoroscopy time values were comparable with other publications.Skin dose values of investigated patients are below the threshold dose for radiation skin injury(2 Gy).There is no good relationship between DAP and PSD.So calculation of individual maximum skin dose based on DAP data is not reliable and needs to find a new reference value for skin dose.(J Intervent Radiol,2007,16:222-225)