Objective To analyze the relationship between family factors and learning motivation of students in Xinjiang Medical University so as to provide scientific basis for promoting the medical undergraduates' learning motivation in the future.Method From April to June in 2014,using stratified cluster random sampling,2 000 college students from Xinjiang Medical University were surveyed by family factors and learning motivation questionnaire,and 1954 effective questionnaire were recycled.SPSS 17.0 was used to analyze the data,T test and variance analysis were conducted to the single factor and multiple linear regression analysis was made to multiple factors.Results All dimensions of 1 954 medical students' learning motivation shown were average,and the score of fear of failure was the lowest (2.82 ± 1.01).There were statistically significant differences in the scores of multiple dimensions of learning motivation of the medical students of different gender,nationality and grade (P＜0.05).And the scores in learning motivation in multiple dimensions of the medical students of different types of accounts,different family relationships,and different parental education level and whether they were the only child also had statistically significant difference (P＜0.05).Multi factor analysis showed that learning motivation,family account type,grade,gender,race,whether they were poor students and family relationships were the factors influencing the learning motivation of medical students.Conclusion Family factors have a great influence on the generation and maintenance of medical students' learning motivation,and it is necessary to change the poor education environment of the family,so as to interfere the students' learning motivation.