Introduction: Non-Hodgkin’s lymphomas (NHLs) are a varied group of malignancy originating in the lymphatic system. As a subset of lymphomas, primary spinal epidural lymphomas are diagnosed when there are no other recognizable sites of lymphomas at the time of diagnosis. It mimics other spinal diseases making the diagnosis difficult to establish as well as in obtaining tissue diagnosis. We present an atypical case of a 45-year-old female who presented initially with back pain then eventual loss of sensory and motor function of the lower extremities, further work up showed primary spinal epidural NHL. Case: This is a case of a 45-year-old female with chief complaint of back pain. Magnetic resonance imaging (MRI) of the thoracic spine showed nonspecific epidural soft tissue mass at T5 to T6 level compressing the spinal cord. Operative procedure was done with histopathology of the epidural lesion consistent of NHL. Immunohistochemical staining showed CD20 (+), thus a diagnosis of diffuse large B cell lymphoma (DLBCL) was made. Patient underwent six cycles of cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) regimen. Conclusion Signs and symptoms of primary spinal epidural NHL often overlaps its manifestations with other spinal diseases. A high index of clinical suspicion warrants inclusion of such neoplastic condition in determining the exact and definitive diagnosis of cases manifesting spinal compression.
Back Pain

Low back pain is an extremely common symptom. Approximately 80% of the general population experience a memorable episode of back pain in their lives. The patients suffering from chronic low back pain have a poor prognosis, with only 20~40% of them improve with multiple treatment trials. Chronic low back pain has various underlying causes, and about 40% are discogenic. The vast majority of patients are treated successfully with nonsteroidal anti-inflammatory medications and physical therapy. However, the number of the minority of patients who fail to respond to these conservative measures is still substantial. When conservative managements fail after a period of months, surgical treatment options should be considered.
Back Pain ; Humans ; Low Back Pain ; Prognosis

Low back pain is an extremely common symptom. Approximately 80% of the general population experience a memorable episode of back pain in their lives. The patients suffering from chronic low back pain have a poor prognosis, with only 20~40% of them improve with multiple treatment trials. Chronic low back pain has various underlying causes, and about 40% are discogenic. The vast majority of patients are treated successfully with nonsteroidal anti-inflammatory medications and physical therapy. However, the number of the minority of patients who fail to respond to these conservative measures is still substantial. When conservative managements fail after a period of months, surgical treatment options should be considered.
Back Pain ; Humans ; Low Back Pain ; Prognosis

Activities ; Infancy, NOS ; Back

No abstract available.
Humans ; Low Back Pain*

No abstract available.
Humans ; Low Back Pain*

No abstract available.
Failed Back Surgery Syndrome*

No abstract available.
Diagnosis* ; Low Back Pain*

No abstract available.
Leg* ; Low Back Pain*

No abstract available.
Incidence* ; Low Back Pain*