Background: Vitamin E is an oil-soluble compound with antioxidant properties against free radicals. It has been used in cosmetic practice since long time ago. However, it is unstable to light and heat, and even when formulated into pharmaceuticals, it has poor skin penetration, which can reduce the effectiveness of the treatment. Therefore, by encapsulating Vitamin E in liposomes and forming a gel, it is possible to produce a highly therapeutically effective drug form that supports skin homeostasis and provides moisturizing benefits. To this reason, it is necessary to determine the appropriate methods and conditions for encapsulation in liposomes, which is the basis for conducting this study. Aim: The goal of the research is to develop a technology for preparing vitamin E-loaded liposomes and incorporating them into a gel formulation. Materials and Methods: Liposomes were formed using thin film hydration, ethanol injection, and heating methods, each with 5 different concentrations, and liposome formation was determined spectrophotometrically for each sample. The size of the formed liposomes was determined using a Nanophox instrument. Six gel models were prepared and compared for quality parameters. Results: The highest yield was obtained when 75 mg of phospholipids were used in the thin film hydration method, which is 82.3%; the highest yield was obtained when 50 mg of phospholipids were used in the ethanol injection method, which is 86.75%; and the highest yield was obtained when 50 mg of phospholipids were used in the heating method, which is 58.8%. The average size of liposomes prepared by ethanol injection and dissolved in distilled water was 106 nm. The gel bases were prepared using models F1-F6, and the pH values of models F4 and F5 were suitable. Conclusions 1. Among the three methods for liposome formation, the ethanol injection method had the highest yield. 2. The ethanol injection method had the highest encapsulation when prepared with a phospholipid:vitamin E ratio of (1:10). 3. For gel base model F5 was suitable which is carbomer 1.0%, preservative propylparaben 0.02%, pH adjuster sodium hydroxide, and permeability enhancer propylene glycol 10%.