1.Technology Of Preparing Film Coated Tablet And Gel From Cacalia Hastata L
Jambaninj D ; Davaasuren Ts ; Erdenetsetseg G ; Baasanjargal N ; Dungerdorj D
Journal of Oriental Medicine 2012;3(2):61-62
Introduction: In 2007, ” National innovation Development
Program in Mongolia” was adopted by 306th act of Mongolian
government and indicated that its important to focus attention to
research outcomes become real productions based on scientific
knowledges, experiences, skilled personnel and possibility of
laboratory and production.
In Mongolian and Tibetan traditional medicine have been used
many herbal and animal preparations has biological active
compound with anti inflammatory effect for the treatment of
wound healing and ulcer. One of them, Cacalia hastata L. is a
medicinal plant, which is widely used for the treatment of wound
healing, cholangitis and gastroduodenal ulcer in the Mongolian
and Tibetan traditional medicine.
It is appropriate to prepare film coated tablet for the treatment of
gastric and duodenal ulcer, gel for the treatment of wound
healing.
Purpose: To prepare film coated tablet for the treatment of
gastric and duodenal ulcer, gel for the treatment of wound
healing from semi-solid extract of Cacalia hastata L. and
determine their quality criteria.
Material and methods: Herb of Cacalia hastata L. was collected
as a raw material from Terelj in July 2009; from Batsumber
soum, Tuv aimag province in July 2010, 2011. For determining
of quality of semi-solid extract and new drug formulations were
evaluated biological activity compounds such as alkaloid,
carotenoid and flavonoid by spectrophotometric method. We
prepared film coated tablet by wet granulation and film coating
method and gel by dispersion method.
Tests for significant differences between means were performed
by one sample t-test and One way ANOVA using the software
SPSS 16. Differences were considered significant at p<0.05.
Results: We prepared tablet from semi-solid extract of Cacalia
hastata L. For preparing the film coated tablet used mixture
solution of 8 % gelatin and 6 % sodium carboxymethylcellulose
as a binder, sodium carbonate as diluents. The tablet was
coated 5% solution of hydroxypropylmethylcellulose with 10 %
polyethyleneglycol as a film former used traditional coating pan.
Film coated tablet was standardized by such criteria, as
appearance (colour, smell), the average weight, amount of
biologically active compound, hardness, disintegration,
dissolution and bacterial contamination. We prepared Cacalia
gel from semi-solid extract of Cacalia hastata L. using various
excipients and determined quality criteria, developed
technological scheme of preparing. Gel was standardized by
such as criteria: appearance (color, smell), the amount of
biologically active compound, pH, viscosity, spreadability,
extrudability and bacterial contamination.
Conclusions: 1. Developed technology of preparing 0.3 gram film
coated tablet from semi-solid extract of Cacalia hastata L. and
determined quality criteria. 2. Developed technology of gel from
semi-solid extract of Cacalia hastata L. and standardized its
quality.
2. Impact of Individual Temperament on the Immune Response After COVID-19 Vaccination
Burenjargal B ; Dashpagam O ; Shatar Sh ; Khongorzul T ; Ariunzaya B ; Zolmunkh N ; Gansukh Ch ; Ulziisaikhan B ; Chimidtseren S ; Baasanjargal B ; Enkh-Amar B ; Nomin-Erdene Ts ; Davaalkham D ; Tsogtsaikhan S ; Batbaatar G
Mongolian Journal of Health Sciences 2025;88(4):47-51
Background:
The first confirmed case of COVID-19 in Mongolia was reported on November 11, 2020. In response, the
government imposed a nationwide lockdown, which significantly impacted the population’s mental health. Heightened
levels of stress, anxiety, loneliness, and depression during the pandemic altered individuals’ psychological stability and
behavior. Personality traits—defined as relatively stable patterns of emotion, cognition, and behavior—play a key role in
stress responses and emotional regulation under pressure. Emerging evidence suggests that these psychological factors
may influence the immune system’s responsiveness, including vaccine-induced antibody production.
Aim:
To evaluate the association between post-vaccination antibody responses and personality types following two doses
of COVID-19 vaccines.
Materials and Methods:
A total of 738 participants who received two doses of COVID-19 vaccines (AstraZeneca
ChAdOx1, n=29; Pfizer-BioNTech, n=119; Sinopharm BBIBP, n=590) and had no prior SARS-CoV-2 infection were enrolled. Serum samples were collected 21–28 days after the second dose, and SARS-CoV-2 RBD (S) IgG antibodies
were measured using ELISA (Proteintech Inc., USA). Personality types were assessed using a 56-item temperament
questionnaire developed by A. Belov, categorizing individuals into classical temperament types (choleric, phlegmatic,
sanguine, melancholic). Logistic regression and ROC analysis were used to examine associations between personality
types and antibody response.
Results:
The presence of an antibody response was significantly higher among individuals with a melancholic temperament, and significantly lower among those with a phlegmatic temperament. Furthermore, antibody titers were higher in
participants with melancholic and sanguine temperaments and lower in those with a phlegmatic type.
Conclusions
1. During the early period following the second dose of COVID-19 vaccination, the antibody response was higher
in individuals with a pure melancholic temperament, while it was lower in those with a phlegmatic temperament.
2. After the second dose of the Sinopharm BBIBP COVID-19 vaccine, antibody titers were higher in individuals with
pure melancholic and sanguine temperaments, and lower in those with a phlegmatic temperament.