2.Microglia in brain metastasis tumor
Journal of International Oncology 2012;39(7):513-515
Microglia(MG)is recognized as the main immune effector in central nervous system injury and disease.MG can regulate the tumorigenesis and development of brain metastases tumor(BMT)by different ways.Studing the roles and mechanisms of MG in BMT will provide new insights into the prevention and treatment of BMT.
3.Progression and challenge of therapeutic strategies in neovascular age-related macular degeneration
Chinese Journal of Ocular Fundus Diseases 2016;32(1):3-7
Choroidal neovascularization (CNV) is the key characteristic of neovascular age-related macular degeneration (nAMD),and the effective therapy is intravitreal injection of anti vascular endothelial growth factor (VEGF) agents based on clinical and basic research.In the meantime the challenge is how to further improve the inhibiting effect for CNV and visual function of anti-VEGF treatment on nAMD.The new strategy and drug delivery devices for anti-VEGF treatment will optimize the clinical scheme.From bench to bedside,the research on targeted treatment of angiogenesis brings the bloom of nAMD medical therapy.
4.Relationship between Cancer-related Fatigue and Hypothalamic-pituitary-adrenal Axis (review)
Chinese Journal of Rehabilitation Theory and Practice 2017;23(4):406-409
Cancer-related fatigue survivors have been found to have lower morning serum cortisol levels, flattened diurnal cortisol cy-cles, and decreased cortisol responses to psychological stress. The mechanism may be related to the inflammation caused by disorder of hy-pothalamus-pituitary-adrenal axis, and there are also some evidences to support that cortisol can be used to reduce cancer-related fatigue. This study introduced the research progress of the relationship between cancer-related fatigue and hypothalamus-pituitary-adrenal axis.
5.Theoretical Research on Regulating Spirit Based on Time Differentiation of TCM
Journal of Zhejiang Chinese Medical University 2017;41(2):117-119
[Objective] To guide the health preservation more scientifically and effectively through discussing relationship between natural timing and spirit-regulating, and studying the influence of lifecycle and time sequence regularity on the spirit-regulating. [Methods] The relationship of body and spirit, time property of the spirit, time sequence regularity and those lifecycle were adopted to analyse the theoretical basis and specific measures on regulating spirit based on time differentiation. [Results] Body as well as the spirit would be followed by the changes of the time sequence regularity, also at different stages of human body, the spirit changed with it accordingly. [Conclusion] TCM holds that body and spirit are unified, the lifecycle and natural timing affect human body and spirit correspondingly, so if we know the relation of the spirit and time, regulate spirit by time differentiation, which must be helpful for keeping good mind, even for health and longevity.
6.Efficacy of CHOP chemotherapy on unspecified peripheral T cell lymphoma in patients aged 80 years and over and its prognostic analysis
Chinese Journal of Geriatrics 2016;35(5):507-510
Objective To evaluate the efficacy of CHOP (cyclophosphamide,doxorubicin,vincristine,and prednisone)chemotherapy on peripheral T cell lymphomas-unspecified (PTCL-U)in patients aged 80 years and over,and investigate the chemotherapy adverse effects and its prognostic factors.Methods Clinical data of 57 patients with PTCL-U confirmed by pathology and immunohistochemistry in Guangzhou First People's Hospital from January 2008 to January 2015 were retrospectively analyzed.The efficacy and adverse effects of CHOP chemotherapy,and its prognostic factors were evaluated.Results Of 57 patients,11 (19.3%) achieved complete remission,23(40.4%)had partial remission,14(24.6%)had stable disease,and 9(15.8%)had progressive disease after CHOP chemotherapy,with a total effective rate of 59.6% (34 cases).The expected 1-year,2-year and 3-year overall survival(OS)rate was 70.2% (40 cases),36.8% (21 cases) and 17.5% (10 cases),respectively.The median survival time was 18.2 months.Among the 57 patients,40(70.2%) had hypoplasia of bone marrow at degree Ⅰ-Ⅱ,17 (29.8%) at degree Ⅲ-Ⅳ,49 (86.0%) had mild nausea and vomiting(degree Ⅰ-Ⅱ),8(14.0%)had severe nausea and vomiting(degree Ⅲ-Ⅳ),7 had liver dysfunction,2 had cardiac toxicity and 7 had disturbance of blood coagulation.Univariate analysis showed that the alkaline phosphatase,Ki-67 percentage,lymphoma international prognostic index(IPI)score,extranodal involved sites(>1),as well as the efficacy and course of chemotherapy were the prognostic factors for survival time in very elderly patients.Multivariate analysis indicated that IPI score>2(95%CI:1.12~6.35,x2 =5.45,P<0.01),extranodal involved sites(>1)(95% CI:2.58-15.32,x2 = 16.42,P<0.01),disease progression(95%CI:1.82~12.15,x2 = 10.23,P<0.01),chemotherapy courses(>4) (5%CI:0.18~0.79,x2 =7.28,P<0.01)were the independent prognostic factors for the median survival time in very elderly patients.Conclusions PTCL U patients aged 80 years and over have poor prognosis.CHOP chemotherapy has a certain effect on PTCL-U in very elderly patients,and chemotherapy side effects can be tolerated.IPI score>2 and extranodal involved sites(> 1)are the important prognostic factors in very elderly PTCL-U patients.The completion of full course of chemotherapy with remission occurrence is important to prolong survival time in very elderly PTCL-U patients.
7.Study on the TCM sydrome spectra of hemopathy
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(10):-
The study process of TCM syndrome spectra of hemopathy is the process to recognize the syndrome characteristics of the onset, development of hemopathy, it bases on norm of TCM symptoms and syndrome. In this course, it could not only find common feature of syndrome,but also analyze distribution regularity of TCM syndrome. Thus to establish sequence of hemopathic syndrome, and to provide the basis for clinic determination of treatment based on syndrome differentiation, and provide the foundation for finding correlation of TCM syndrome and target tests.
8.MICRO-VASCULAR STRUCTURE OF THE SKIN AND SUPERFICIAL AND DEEP FASCIA IN THE MEDIAL PART OF FOOT UNDER SCANNING ELECTRON MICROSCOPE
Acta Anatomica Sinica 1954;0(02):-
The fresh cadavers were injected with A. B. S into the popliteal arteries. We have studied the micro-vascular structure of this skin area under scanning electron microscope. There are 5 layers of the vascular network in this skin area. They were formed by the small branches coming from either the direct or indirect cutaneous arteries. The 5 layers are as follows: The capillary network of the papillary layer. The vascular network of the subpapillary layer. The deep dermal network. The network in the subcutaneous tissue. The network in the deep fascia tissue. It is clear that each layer of the vascular network has it's -own special character.
9.SCANNING ELECTRON MICROSCOPE STUDIES OF THE MICROCIRCULATION IN THE NAIL BED OF THE TOE
Acta Anatomica Sinica 1954;0(02):-
The vascular morphological character of the microcirculation in the nail bed of the toe have been studied with the scanning electron microscope. Three types of vascular network were identified: 1) The blood vessels at the proximal two fifth of the nail bed were parallelly arranged. 2) At the middle two fifths of the nail bed, the blood vessels interwoved with each other and formed the polygonal vascular networks. 3) At the distal one fifth of the nail bed there were only a few vascular loops running in a slanting position. These loops were connected with the vascular network from the papillary layer of the skin of the toe.
10.Using Shenghua decoction though syndrome differentiation following childbirth
China Journal of Traditional Chinese Medicine and Pharmacy 2006;0(09):-
Shenghua decoction made by FU Qing-zhu is a famous formula aimed at syndrome of coagulation cold due to blood deficiency,static blood obstruction.The mechanism of disease is definite when this formula is applied.But the extensive use of Shenghua decoction,especially some potent preparation of it following childbirth without according to TCM principle based on differentiation of syndromes is a manifestation of highlighting formula and underestimating theory,which is useless and harmful.It should be emphasized.So the Shenghua decoction should be used under the direction of basic theory of TCM,through precise syndrome differentiation,according to the principle of "looking to and not being besieged by postpartum ".We should not follow blindly the method of treatment of "warming and resolving stasis" on the postpartum disease.It is important that Shenghua decoction should be used on the basis of syndrome differentiation.