Expression and regulation of genetic genes determine the senescent process. Generally, aging has been regarded as an irreversible process. Along with age increasing, each organ of the body including immune system experiences senescence. Immunosenescence promotes the age-related diseases, such as tumor, cardiovascular diseases, Alzheimer's disease, osteoporosis, and so on. These diseases seriously affect the quality of human life and longevity. How to delay senility, maintain immune function, and keep a good health have become the hot points of social concerns. Inthisreview, by discussing theaging, immunosenescence and its related diseases, aging and tumor treatment as well as anti-aging and disease treatment etc, we explore the mechanisms, prevention and treatment of senescence, senescence-related disease and anti-aging.