Objective:To examine the in vitro and in vivo anti-Trypanosoma evansi (T. evansi ) activity of saponins-rich fraction of Calotropis procera (cpsf) leaves as well as the effect of the fraction on the parasite-induced anemia. Methods:A 60-minutes time course experiment was conducted with various concentrations of the fraction using a 96-well microtiter plate technique, and subsequently used to treat experimentally T. evansi infected rats at 100 and 200 mg/kg body weight. Index of anemia was analyzed in all animals during the experiment. Results:The cpsf did not demonstrate an in vitro antitrypanosomal activity. Further, the cpsf treatments did not significantly (P>0.05) keep the parasites lower than the infected untreated groups. At the end of the experiment, all T. evansi infected rats developed anemia whose severity was not significantly (P>0.05) ameliorated by the cpsf treatment. Conclusions:It was concluded that saponins derived from Calotropis procera leaves could not elicit in vitro and in vivo activities against T. evansi.

BACKGROUND: Research is the act of inquiry to know and is one of the pivotal points and fundamental goals of a university. It is an important part of an academic job and is believed to be the next most valued part of their duty after teaching OBJECTIVES: This study aims to determine the research productivity of Nigerian academics in medicine and allied health sciences disciplines in Nigeria. METHODOLOGY: 177 participants completed a 41- items questionnaire that elicits information on sociodemographic, the institution, the program, and research productivity (research papers, conferences attendance and presentation, and book chapters) using a multistage cluster random sampling of Nigerian Universities. RESULTS: Majority of the included participants were male (70.06%), married (79.14%), and below the senior teaching cadre (38.99%). Majority of the academicians do not have any training overseas (67.06%) and have indicated time as a constraint to research productivity (67.06%). Three papers in the past two years is an indication that Nigerian academics in the medical and allied health sciences, on average, may not be deemed to be highly productive. Professors (16.58+27.14) and those in higher ranks (Readers: 11.84+11.22 and senior lectures 12.58+13.53) have published more papers than their counterparts in the junior cadre (lecturer I and II: 4.87+6.58 and 2.69+3.87). Academics in the present study has a median research grant of zero in the past two years. A simple majority of the participants (55.29%) agree on mandating of PhD for promotion and career advancement of academics. There is no difference in the number of papers published (6.04+10.52 and 7.62+13.21) or conferences attended (7.42+19.14 and 4.04 +4.02) between academics in private and public Universities CONCLUSION Apparently low and dismal productivity by these academics in medicine and allied health sciences affirm the need for capacity building on an ongoing basis.