Objective: In hospitals, the most recent medical information paper delivered by the hospital pharmacy is essential for obtaining information about the newest therapies and/or avoiding adverse effects of medicines.  To improve the medical information paper (hereafter, Medical News), we investigated the dissemination of Medical News delivered monthly by the Pharmaceutical Department in Oami Hospital.
Methods: Questionnaires about Medical News were distributed to each occupational category working in Ohami Hospital, and collected during June and July 2010.
Results: Responses were obtained from 127, including 19 doctors (full-time and part-time).  Ninety (70.9%) knew about Medical News, and 75 (59.1%) had read it.  It was revealed that there were differences in the familiarity with to Medical News among job classifications, and articles described on the same Medical News.
Conclusion: It insufficient to satisfied to provide drug information as a one-way provision by Medical News; however, as there are differences in the information required for each job, it is difficult to deliver a large number of copies in the small-scale hospital.  Overlooking the most up-to-date information about medicine and medical devices can lead to serious problem.  We have to review the information and provide important and accurate drug information to the staff in our hospital.

As an environmental risk factor, psychological stress may trigger the onset or accelerate the progression of Parkinson's disease (PD). Here, we evaluated the effects of acute restraint stress on striatal dopaminergic terminals and the brain metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which has been widely used for creating a mouse model of PD. Exposure to 2 h of restraint stress immediately after injection of a low dose of MPTP caused a severe loss of striatal dopaminergic terminals as indicated by decreases in the dopamine transporter protein and dopamine levels compared with MPTP administration alone. Both striatal 1-methyl-4-phenylpyridinium ion (MPP) and MPTP concentrations were significantly increased by the application of restraint stress. Striatal monoamine oxidase-B, which catalyzes the oxidation of MPTP to MPP, was not changed by the restraint stress. Our results indicate that the enhanced striatal dopaminergic terminal loss in the stressed mice is associated with an increase in the transport of neurotoxin into the brain.
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; metabolism ; 1-Methyl-4-phenylpyridinium ; metabolism ; Animals ; Corpus Striatum ; drug effects ; metabolism ; Disease Models, Animal ; Dopaminergic Neurons ; drug effects ; MPTP Poisoning ; chemically induced ; metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Neurotoxins ; metabolism ; Restraint, Physical ; Stress, Psychological ; metabolism