The histopathological and ultrastructural changes of the lungs of 11 pigs suffering from comminuted fracture of the femur produced by high-velocity sieel bullet were studied. The steel bullet was 7.62 mm in diameter and 1.03 g in weight. The pulmonary changes were observed 24, 48, and 72 hours after injury.It was found that microvascular congestion, aggregation of RBC and WBC, and degranulation of WBC were prominent features 24 hours after injury. The basement membrane of the endothelium was broken. Type I pneumocytes became swollen and deteriorated. The lamellar bodies of Type II pneumocytes were evacuated rapidly. 48 to 72 hours after injury, these pathological changes gradually ameliorated.The pulmonary pathology occurring after bullet - induced fracture observed in this study is similar to that of adult respiratory distress syndrome(ARDS) in character but much milder in intensity. Its prognosis is always fine. Most of the experimental animals showed no symptoms or signs of ARDS. It is concluded that severe limb trauma can induce subclinical ARDS.

On 8 dogs a moderate hypotension is produced by stcpwisc blood loss of 24ml/kg for 60 min At the end of this period the shed blood is rcinfuscd back in the animal.Results of observation after 60 min demonstrate a significant (p

Effect of exercise on placental blood flow and fetal heart rate was studied using Acuson 128 color computer ultrasound equipment The subjects were ten healthy women ranging from 27 to 35 gesta- ' tional weeks (mean 30.7 weeks). After exercise, the matcrnal mean arterial pressure increased significantly, maternal heart rate rose and amounted to 60%-75% of maximal heart rate (both P0.05). The fetal heart rale rose but within normal limit. These showed that the responses of maternal blood vessel and fetal blood vessel of placenta to the exercise were different This intensity and time of exercise could improve uterine blood flow and reduce its vascular resistance. However, they didn't influence the umbilical artery blood flow. Also the change of fetal heart rate was within normal limit. It is concluded that the moderate and non-exhaustive maternal exercise can improve the supply of the placental blood flow and benefit to the 2nd and 3rd trimister healthy pregnant women.

Objective: design knee prostheses infection modal for rabbits. Methods:The knee implants were designed with 3mm To Kirschner wire for the length of 15mm.Implanted the stem to the distal femoral through intercondylar fossa.forty eight rabbits were divided into 4 groups randomly,12 in each group and finished above-mentioned surgery. Immediately after the surgery,0.5 ml 1?107 CFU of Staphylococcus aureus ATCC 25923 was injected into the joints of group A,0.5 ml 1?106 CFU in group B and 0.5 ml 1?105 CFU in group C, group D were not injected.the animals were sacrificed 2 weeks after injections, wounds were observed and X-ray films were and taken. levels of serum CRP and ESR determined,pathological changes were observed and bacteria cultures were performed. Results: After staphylococcus aureus was injected into the joints right after the surgery.100% knee joint infection in group A and 100%in group B, 83.3% in group C,none knee joint infection in group D. A large amount of inflammatory cells were found in the infected samples, theand levels of serum CRP and ESR were elevated in the infected samples. Conclusion:An animal model of TKA infection can be established successfully at 2 weeks by 0.5 ml 1?106 CFU staphylococcus aureus ATCC25923 injecting into the joints immediately after the surgery.

In 1989 ,a general survey of diabetes mellitus and impaired glucose tolerance(IGT) in 44 747 Shanxi peasants,as well as Beijing and Liaoning workers and cadres revealed that the prevalence rate of diabetes and IGT was 2. 02% and 2. 95 % respectively. The former was greatly increased in comparison with that in 1979. The prevalences of diabetes and IGT in Beijing and Liaoning were much higher than in Shanxi, where the caloric-intake and the percentages of overweight and obesity in peasants were much lower. The prevalence rate of diabetes and IGT increased with age,with the peak in 60s. Most of patients with diabetes or IGT were non-obese, but it was significantly higher in overweight or obesity groups. These indicate that aging,lack of physical exercise,overeating and obesity are major factors in increasing the prevalence rate of diabetes mellitus and IGT. A significant difference in prevalence rate of diabetes between male and female was found. Its cause and significance need further study.

The toxioity of rivanol(home product)in animals was investigated according to the standard in Chinese Pharmacopoeia. Acute toxicity ,subacute toxicity and cumulative toxicity in mice,sensi-tization in guinea pigs and subchronic toxicity in dogs were tested. In acute toxicity test,the LD50 (IV)was 18. 494?2. 90mg/kg,which belonged to be a moderate toxic substances. When the dose was 1mg/kg,no toxic effect was observed in any animal. When the dose(IV)increased to 5mg/kg, mild degeneration and focal necrosis of cells,infiltration of inflammatory cells and proliferation of Kuffer'cells were shown in liver of mice while no toxic effect was observed in dogs. In cumulative toxicity test,the LD50 was 19. 3mg/kg which was more than Ld50 suggested that there was some tolerance and cumulative toxicity effect might not be present in mice. There was no sensitization showed in guinea pigs when rivanol was given via abdomenal administration.

Objective:To explore the relationship between genetic polymorphism of ALDH2 and CYP2E1 and alcoholic liver disease(ALD) in Han people. Methods:PCR-RFLP was used to detect the frequencies of gene types and allele of ALDH and CYP2E1 in health control group(45 cases),ALD group(48 cases),alcohol dependent group(38 cases) and non-ALD(NALD) group(42 cases),and the frequencies were compared. Results:The difference of the frequencies of ALDH2*1 and ALDH2*2 had statistic significance between health control group and ALD group,and between in ALD group and NALD group(P

This article presents an advanced dental diagnostic instrument-the pre-pain sensation electric pulp tester with current indication. The tester adopts an alternating current signal generator with a specific frequency as the stim- ulating source which can induce a pre—pain sensation similar to a cool-sour feeling or tingling without causing any pain when the current flows through the patient's dental pulp.The dentist can judge the vitality of the dental pulp by the data displ.ayed on the tester.The tester is superior to other similar instruments both at home and abroad with its better accuracy and repeatability. This instrument adopts the integrated circuit and some other new techniques such as automatic boost,automatic switching on and off of the power and automatic data-holding. Compact,light and easy to operate it has high reliability,safety and low power consumption. At present,it is a more advanced dental electric pulp tester.

Studies of the scalps from 42 patients with alopecia areala are given,using direct immunofluorescence ( DIP).Langerhans cells (LC)and T-lyrn hocytc subsets are observed.There is no significant difference between the number of OKT6 cells and Ia+ cells in the epidermis of all groups and the control.LC is seen in hair-bulb in many patients and most frequently in active stage.The main change of LC in hair follicle is increasing of T6+Ia- cells,not significant of T6+Ia+ cells.Most of the infiltrates around the hair follicles are T( OKT3+) cells.T4+cells number and T4/T8 ratio in active arc larger than in resting and recovering stages.DIF shows 88% of the patients having deposits of C3,IgG,and IgM.This suggests that alopecia areata may be the disorder of immnue associated with cellular and humoral immunity.

The aims of this study are to obtain a suilablc condition for the cardioplasty with the fundoplication and an observation of the effect of the antircflux function following the operations. The results show that a suppcrting dcvicc of a round tube with 1 - 1.2 ctn diamcter is used as a guide to establish a good lovver esophageal sphinctcr(LES). The experimental ani-mais may survive very long. The pressure in the sphimcter is cvenly the same as that after the operation immediately. The gastroesophageal reflux is never occurred except intragastric pres-sure is the same as or higher than LES. The lower csophagcal high pressure zone formed is similar to the smooth muscle in the lower part of csophagus at the sile of opcralions . The new formed cardia plays an excellent role of anturc flux function . This report suggists that the cardioplasty with fundoplication is useful for the treatment of esophageal achalasia and somc other abdpminal disorders.