·AIM: To evaluate the extent of significant posteriorcapsule opacification (PCO) after implanting polyme-thylmethacrylate (PMMA) and soft acrylic intraocular lenses.·METHODS: A total of one hundred patients (110 eyes) undergoing intraocular lens (IOL) implant surgery were randomly divided into two groups based on the type of IOL's implanted. Group Ⅰ: AcrySof (SA60AT) and Group Ⅱ: PMMA (LX10BD). The density of posterior capsular opacification (PCO) was assessed 3, 6, 12 and 18 months after surgery by taking best corrected visual acuity (BCVA) and the digital photographs.·RESULTS: At the end of 3 months postoperatively, the PCO density in the Group Ⅰ (PMMA) increased significantly (3.6%) while no increase was found in the Group Ⅱ (Acrylic). By the end of 18 months follow up, the incidence of significant PCO was found to be less in the acrylic group (14.5%) as compared to the PMMA group (34.5%). On the basis of density, the PCO was more extensive with the PMMA lens than the AcrySof lens, which led to more severe visual loss.·CONCLUSION: The intraocular implantation of the AcrySof IOL helps to reduce the incidence of PCO to a greater degree as compared to the PMMA IOL.