Introduction. Garidi-5, a traditional medicine composed of 5 herbs including Terminalia chebula Retz., Aconitum Kusnezoffii Reichb., Acorus calamus L., Saussurea lappa L., and musk of Moschus moschiferus, has been used in traditional Mongolian medicine as an analgesic and antibacterial medicine. The present work was undertaken to evaluate the traditional drug Garidi-5 for its analgesic and anti-inflammatory activity.Materials and Methods. The method of Winter et al. was used to study acute inflammation. Rats in groups of five each were treated with vehicle, Garidi-5 (20, 80 and 200 mg/kg, p.o.) and Indometacin (10 mg/kg) one hour prior to Carrageenan injection. 0.1 ml of 1% Carrageenan was injected into the subplantar tissue of left hind paw of each rat. Swelling of carrageenan injected foot was measured at 0, 0.5, 2, 4 h using Plethysmometer (UGO Basile, Italy)). The right hind paw was injected with 0.1 ml of vehicle.Results. The Garidi-5 (20, 80 and 200 mg/kg) significantly (P<0.01) inhibited carrageenan induced rat paw edema as compared to control group. Maximum inhibition of paw edema was observed with Garidi- 5 (80 and 200 mg/kg) at 4 h when compared to the control group (Tab.1). In assay data, the TNF-α, IL-1β and IL-6 secretion in serum were highly elevated by carrageenan induction but administration of Garidi-5 signifi cantly reduced serum secretion of inflammatory mediatorsas compared to vehicle group (Tab. 2).Conclusion. In conclusion, Traditional drug Garidi-5 have anti-in flammatory properties. The potential efficacy of Garidi-5 to treat inflammation is based in a part on the hy pothesis that it will suppress the proinflammatory cytok ines resulting in less oedema.

Introduction. Garidi-5, a traditional medicine composed of 5 herbs including Terminalia chebula Retz. Aconitum Kusnezoffii Reichb., Acorus calamus L., Saussurea lappa L., and musk of Moschus moschiferus, has been used in traditional Mongolian medicine as an analgesic and antibacterial medicine. The present work was undertaken to evaluate the traditional drug Garidi-5 for its analgesic and anti-inflammatory activity.Materials and Methods. The method of Winter et al. was used to study acute inflammation. Rats in groups of five each were treated with vehicle, Garidi-5 (20, 80 and 200 mg/kg, p.o.) and Indometacin (10 mg/kg) one hour prior to Carrageenan injection. 0.1 ml of 1% Carrageenan was injected into the subplantar tissue of left hind paw of each rat. Swelling of carrageenan injected foot was measured at 0, 0.5, 2, 4 h using Plethysmometer (UGO Basile, Italy)). The right hind pawwas injected with 0.1 ml of vehicle.ResultsThe Garidi-5 (20, 80 and 200 mg/kg) significantly (P<0.01) inhibited carrageenan induced rat paw edema as compared to control group. Maximum inhibition of paw edema was observed with Garidi-5 (80 and 200 mg/kg) at 4 h when compared to the control group (Tab.1). In assay data, the TNF-α, IL-1β and IL-6 secretion in serum were highly elevated by carrageenan induction but administration of Garidi-5 signifi cantly reduced serum secretion of inflammatory mediators as compared to vehicle group (Tab. 2). ConclusionIn conclusion, Traditional drug Garidi-5 have anti-in flammatory properties. The potential efficacy of Garidi-5 to treat inflammation is based in a part on the hy pothesis that it will suppress the proinflammatory cytok ines resulting in less oedema.

Introduction: Among the ancient medical books, manuscripts written in clear script, with unique vocabulary and treatment methods, have been found. The vocabulary in this work is very ancient, and the treatment methods are systematic, with few mentions of theoretical concepts. Most of the unfamiliar words were written in the pronunciation of the ancient Oirat Torghut and Dorbet. Some of these words were of Uyghur and Sartuul (Khui Khui) origin. Therefore, we worked to determine when and by whom this book was written, what its content was, and which direction of medicine it belongs to. Objectives: To study an ancient book written in clear script, containing Islamic medical knowledge, found in Mongolia. Results “The Healing Charm of Blue Ram” (Khökh khutsyn uvdis orshivai) records that Genghis Khan ordered Chagatai Khan to send him medical books from his land. He may have been in poor health shortly after the founding of the Chagatai state in 1225. Thus, he ordered Chagatai to send him books containing medical methods. It is reasonable to assume that the books were sent in 1226. At that time, the Chagatai state was highly developed, consisting of many ethnic groups, including Khorezm, Sartuul, and Uyghurs, who practiced Islam. In particular, the medical field was well advanced, resulting in many excellent doctors and medical books. We tried to list and explain a total of 15 words from “The Healing Charm of Blue Ram,” with many more to explore in the future. In general, it is hypothesized that many vocabulary related to medicine have spread to the Mongolian vocabulary through Arabic, Turkic, Uyghur, and Sartuul among the Western Mongolians. Conclusion: The ancient book “The Healing Charm of Blue Ram” found in Mongolia, written in clear Mongolian script, contains Islamic medical knowledge, as well as traditional Mongolian medicine methods, as is clear from the explanations of some vocabulary related to medicine. In the future, it is important to further clarify how Mongolian medicine and Islamic medical knowledge influenced each other and the contribution of Mongol khans to the development of the Ilkhanate and the Chagatai state in the study of the history of Mongolian medicine.