Introduction: Cancer is a deadly disease, caused by benzopyrene which found in cigarettes. The moderate intensity of exercise can affect cancer growth, but how the role it to p53 mutant is not clear. This research proved the expression of p53 mutant in Mus musculus by moderate intensity of exercise. Method: Eighteen animals, were divided into three groups namely, group A, injected by oleum olivarium in the upper buccal mucosa and not given moderate intensity of exercise and benzopyrene; group B, injected benzopyrenes in the same regio, not given moderate intensity of exercise; group C injected benzopyrenes in same region, given moderate intensity of exercise. Moderate intensity of exercise given 3 times every week for 3 months. Oleum olivarum and benzopyrene injection, was given 3 times every week for 1 month, starting at week 5. At the beginning of the 13th week, a bend was taken in the right upper buccal mucosa, then the tissue was processed, painted by immunohistochemical methods. p53 mutant expression was determined by looking at preparations, using an Olympus light microscope with a magnification of 400x. p53 mutan expression was observed in 10 different visual field, then the mean was taken. Result: There were differences in p53 mutant expression in the three groups (p= 0.000), and the highest expression was in group B. Conclusion: The moderate intensity of exercise could decrease p53 mutant expression on squamous cell epithelial of oral Mus musculus.

The ovaries represent the female reproductive organs that determine the women's fertility status and their systemic and oral health, correlating to sex steroid hormone alteration. This study aimed to investigate the effect of cassava leaves extract treatment to SOD expression in the animal model-ovaries after Porphyromonas gingivalis injection. 15 female Sprague Dawley rats were used and divided into five groups: (1) control without cassava leaves extract treatment (C); (2) P. gingivalis without cassava leaves extract treatment (T1); (3) P. gingivalis and cassava leaves extract (T2); (4) P. gingivalis and vitamin C (T3); and (5) P. gingivalis and metronidazole (T4). Animal were euthanised at day seven after the initial treatment to collect ovaries. The ovaries sections were immunohistochemically stained to quantify SOD expression using light microscope while the Image J software was used to quantify the SOD expression. The results showed that all of the follicle types had the same intensity of SOD expression. Most of the follicles exhibited low intensity of SOD expression, except for atretic follicles. In conclusion, P. gingivalis and cassava leaves extract influenced SOD expression in the ovaries of animal models, which increased the SOD expression.