Objective To probe into modulation effect between the EDRF/NO And ET.Methods In the whole Wister rat and rat's aorta perfusion model,they are carried through relative factors so that dynamic change of MABP,plasm ET-ir and cGMP level of tissue is observed.Results Whole Wister rat's experiment results:① In ET group,MABP first instantly(1~2min)reduces 6.58?0.67kPa,afterwards duratively enhances,it assumes the bidirectional response,when it reaches to 30min,MABP elevates 33.3?0.4kPa than before taking ET;Causes the aortic cGMP content to elevate,comparatively group control to increase 74.5%;② In L-NNA group,MABP slow rise,within 30min elevates to 4.62?2.04kPa;With control group comparison,the GMP level is reduced 5 times(0.42?0.08 versus the control 2.14?0.18pmol/mg Pr,P0.05);④ In Ach group,The vascular ET release reduces [406?31 versus control group 514?50pg/(g.w.w),P

Objective To probe into modulation effect between the EDRF/NO And AngⅡ.Methods In the whole Wister rat and rat's aorta perfusion model,they are carried through relative factors so that dynamic changes of plasm AngⅡ-ir,cGMP level of tissue and vascular AngⅡ release level are observed.Results Whole Wister rat's experiment results:In AngⅡ group,the aortic cGMP content is markedly elevated compared with group control(P

As part of medical scientific spirits and closely associated with medical ethics,medical rational spirit is the spiritual foundation of medical treatment activities and thus should evolve compatibly with medical science.Due to the specific characteristics of medical science,a noble and steady medical rational spirit is an important factor in accelerating harmonious medical consumption and basic request for the application of logic inevitability of medical purpose.

Taking medical morality unrturance of systematicness and practicality,the medical workers and medical students should have a soberly and definitely understand,and hold idea to bringing society effect and basic request of medical morality,meaning of medical aim and peristing in making good morality,medical morality culture,and setting medical logos spirit and etc problems.It is a realism proposition for perspicuiting basic elements and inertia factors of medical logos spirit,and unity od medical ought and medical logos spirit.

Objective To observe effect of large blood vessel hypoxia on the Wister rat′s NO activity. Methods Thoracic aorta rings model with full endothelium and removed endothelium of Wistar rat were prepared , hypoxia stimulated aorta rings and noted changes of constriction extent. Results Endothelium full , removed endothelium aorta rings by hypoxia contract extent difference was 598?42mg and 208?38mg, both had significance discrepancy (P0.05), and NTG made blood vessel contract to reduce range, reach 57.21% (P

The effect of GABA ergic system in the brain in mediating convulsions induced by quinolinic acid (QA) was studied. Muscimol,an agonist of GABAA-receptor, and aminooxyacetic acid (AOAA),an inhibitor of GABA transami-nase(GABA-T) ,and alprazolam which increased the affinity of GABA-receptor as it binds with benzodiazepine-receptor, were used to increase GABAergic function in the brain. Results showed that the above substances antagonized QA-induced convulsions. In contrast, bicu-culline,an antagonist of GABAA-receptor, and 3-mercaptopropionic acid (3-MP), an inhibitor of both GABA synthesis and its release, were used to decrease GABA ergic function in the CNS. They were found to potentiate QA-induced seizures. All these results suggest that GABA ergic system in brain plays an important role in modulating QA-induced convulsions.

Objective:To investigate the surgical decision-making types and its influencing factors for obesity patients participating in bariatric metabolic surgery.Methods:The survey targets were patients who were scheduled to bariatric metabolic surgery in The First Affiliated Hospital of Nanjing Medical University, and the survey period was from January 1 to May 30, 2024. The survey was conducted using the general demographic questionnaire, control preference scale, and shared-decision requirements questionnaire for bariatric metabolic surgery. Count data were expressed as absolute numbers and percentages, and comparison between groups was performed using the chi-square test. Comparison of ordinal data was performed using the non parametric test. Univariate analysis was performed using the corresponding statistical methods based on data types. Multivariate analysis was conducted using the willingness of patients to participate in bariatric metabolic surgery decision-making (passive decision-making=1, shared decision-making=2, active decision-making=3) as the dependent variable, and the statistically significant variables in univariate analysis were included as independent variables for disordered multi-class Logistic regression analysis.Results:(1) Results of survey. A total of 568 questionnaires were distributed and collected. After removing 48 unqualified questionnaires, 520 valid questionnaires were collected. Of the 520 patients who completed the questionnaire survey, there were 231 cases participating as the passive decision-making type, 140 cases as shared decision-making type, and 149 as active decision-making type in bariatric metabolic surgery decision-making. (2) Influencing factors for decision-making type of obesity patients participating in bariatric metabolic surgery. Results of multivariate analysis showed that taking the shared decision-making type as a reference, the number of complication (0 compared to ≥4, 1?3 compared to ≥4), medical payment method (medical insurance compared to self-payment), degree of disease understanding (not very understanding compared to general understanding, not understanding compared to general understanding), and the interval between knowing and accep-ting surgery (1-3 months compared to >6 months) were independent factors influencing the willingness of passive decision-making patients to participate in bariatric metabolic surgery deci-sions ( odds ratios=3.520, 2.457, 2.255, 3.147, 1.920, 1.854, 95% confidence interval as 1.552-7.984, 1.215-4.968, 1.335-3.809, 1.865-5.311, 1.025-3.596, 1.065-3.230, P<0.05). Body mass index (BMI) (28.0-31.9 kg/cm 2 compared to ≥37.0 kg/cm 2, 32.0-36.9 kg/cm 2 compared to ≥37.0 kg/cm 2), number of complication (0 compared to ≥4, 1?3 compared to ≥4), family and social support status (poor compared to good), and the interval between knowing and accepting surgery (1?3 months compared to >6 months) were independent factors influencing the willingness of passive decision-making patients to participate in bariatric metabolic surgery decisions ( odds ratios=2.391, 2.478, 6.918, 3.335, 2.974, 2.139, 95% confidence intervals as 1.207-4.735, 1.345-4.563, 2.498-19.159, 1.350-8.242, 1.755-5.039, 1.156-3.957, P<0.05). Taking the passive decision-making type as a reference, BMI (28.0-31.9 kg/cm 2 compared to ≥37.0 kg/cm 2, 32.0-36.9 kg/cm 2 compared to ≥37.0 kg/cm 2) and family social support status (poor compared to good) were independent factors influencing the willingness of passive decision-making patients to participate in bariatric metabolic surgery decisions ( odds ratios=0.404, 0.554, 0.336, 95% confidence interval as 0.221-0.740, 0.327-0.938, 0.212-0.534, P<0.05). (3) Analysis of decision support needs for bariatric metabolic surgery. Results of shared-decision requirements questionnaire showed that the information needs of obesity patients from high to low were surgical indications, postoperative physical changes and dietary habits adjust-ments, surgical costs, surgical complications and risks, and surgical outcomes. The demand for content preference from high to low were in the form of sharing patient experience after bariatric metabolic surgery, comparing before and after bariatric metabolic surgery, popularizing science after bariatric metabolic surgery, introducing surgical methods, live streaming of medical staff, and introducing the hospital environment. In terms of recognition of networked support pathways, 94.04%(489/520) of patients believed that implementing shared decision support based on networked pathways was reliable. Conclusions:Obesity patients are more willing to participate in bariatric metabolic surgery decision-making. But the proportion of patients selecting passive decision-making is relatively high. BMI, number of complication, medical payment method, degree of disease under-standing, family and social support status and the interval between knowing and accepting surgery are independent factors influencing the willingness of obesity patients to paticipate in bariatric metabolic surgery decisions.

Food allergy are triggered by an abnormal immune response to specific food components, with milk and eggs being the most common food allergens, especially in children. Food allergy can cause various symptoms such as rashes, difficulty breathing, and digestive issues. Allergen component diagnostics is a technique used to identify specific allergenic proteins, aiding doctors in providing more precise treatment and management recommendations for patients. This article analyzes the latest research developments and clinical significance of milk and egg allergen components based on the " Molecular Allergology User′s Guide 2.0 (MAUG 2.0)" issued by the European Academy of Allergy and Clinical Immunology (EAACI), including their applications in clinical diagnosis, treatment, and management. This article aims to enhance healthcare professionals′ understanding of milk and egg allergies, offering new perspectives and practical guidelines for research and clinical practice to promote accurate diagnosis and personalized treatment strategies.

Shellfish, being one of the eight major food allergens, affects approximately 3% of the global population. The occurrence of shellfish allergy is not only related to the individual′s immune system sensitivity but is also influenced by geographical environment, food availability, and dietary habits. Although crustaceans (such as shrimp, crab, and lobster) and mollusks (such as oysters, mussels, and squid) are collectively referred to as shellfish, they exhibit significant differences in biological evolution and the spectrum of allergenic molecules they contain, leading to various allergic reactions. Accurate identification of allergenic proteins is crucial for the diagnosis and management of shellfish allergies, with key allergenic protein families including tropomyosin, arginine kinase, and hemocyanin. Furthermore, due to the diversity of shellfish allergens and their cross-reactivity with dust mite and insect allergens, diagnosing and managing shellfish allergies is complex, especially concerning tropomyosin and arginine kinase protein families. Currently, there are no specific immunotherapy treatments for shellfish allergies, and clinical management primarily relies on avoiding allergens and using anti-allergy medications. This article thoroughly interprets the " Molecular Allergology User′s Guide 2.0 (MAUG 2.0)" published by the European Academy of Allergy and Clinical Immunology (EAACI) and the latest research on shellfish allergies both domestically and internationally. It highlights the significant role of allergen component diagnostics in optimizing the diagnostic and treatment processes for shellfish allergies, effectively assisting clinicians in accurately identifying common allergens and cross-reactions, thereby providing patients with more personalized diagnosis and treatment plans.

Vegetable and fruit allergies are common types of food allergies worldwide, most of them are triggered by primary sensitization to pollen. Most allergens in vegetables and fruits belong to a few cross-reactive proteins such as PR-10 proteins, profilins, and nsLTPs. The presence of these allergens in various plants can lead to widespread cross-reactive allergic responses. Component-resolved diagnostics (CRD) can improve diagnostic accuracy by precisely identifying specific allergenic proteins, aiding physicians in making more accurate treatment and management decisions, and reducing unnecessary food avoidance. This article, based on the "Molecular Allergology User′s Guide 2.0 (MAUG 2.0)" issued by the European Academy of Allergy and Clinical Immunology (EAACI), analyzes the primary mechanisms, relevant allergens, and diagnostic and clinical management strategies for vegetable and fruit allergies. By detailing and analyzing these allergenic components, this article may help the healthcare professionals to deep the understandings of vegetable and fruit allergies, offer new perspectives and practical guideline for the research and treatment of these allergies, and promot the development of precise diagnostics and personalized treatment strategies.