1.Ultrasound evaluation of clinical mimics of deep vein thrombosis: essential insights for radiologists in interpretation
Dongsuk IM ; Lyo Min KWON ; Sun Young PARK ; Min Su PARK ; Won Ju HONG
Ultrasonography 2025;44(3):171-188
Ultrasonography (US) is a sensitive and radiation-free technique for diagnosing deep vein thrombosis (DVT). Therefore, when DVT is clinically suspected but not detected on US, radiologists should consider a range of alternative differential diagnoses. This review article presents the imaging findings of clinical conditions that mimic DVT, which can be distinguished using a multimodal radiologic approach. Additionally, DVT mimics can be categorized into two groups based on whether a flat or normal waveform is observed on Doppler US. This article details the imaging findings and clinical presentations of DVT mimics, organized by these classifications. This information may help radiologists make more accurate diagnoses, enabling patients to receive appropriate treatment in a timely manner.
2.Ultrasound evaluation of clinical mimics of deep vein thrombosis: essential insights for radiologists in interpretation
Dongsuk IM ; Lyo Min KWON ; Sun Young PARK ; Min Su PARK ; Won Ju HONG
Ultrasonography 2025;44(3):171-188
Ultrasonography (US) is a sensitive and radiation-free technique for diagnosing deep vein thrombosis (DVT). Therefore, when DVT is clinically suspected but not detected on US, radiologists should consider a range of alternative differential diagnoses. This review article presents the imaging findings of clinical conditions that mimic DVT, which can be distinguished using a multimodal radiologic approach. Additionally, DVT mimics can be categorized into two groups based on whether a flat or normal waveform is observed on Doppler US. This article details the imaging findings and clinical presentations of DVT mimics, organized by these classifications. This information may help radiologists make more accurate diagnoses, enabling patients to receive appropriate treatment in a timely manner.
3.Ultrasound evaluation of clinical mimics of deep vein thrombosis: essential insights for radiologists in interpretation
Dongsuk IM ; Lyo Min KWON ; Sun Young PARK ; Min Su PARK ; Won Ju HONG
Ultrasonography 2025;44(3):171-188
Ultrasonography (US) is a sensitive and radiation-free technique for diagnosing deep vein thrombosis (DVT). Therefore, when DVT is clinically suspected but not detected on US, radiologists should consider a range of alternative differential diagnoses. This review article presents the imaging findings of clinical conditions that mimic DVT, which can be distinguished using a multimodal radiologic approach. Additionally, DVT mimics can be categorized into two groups based on whether a flat or normal waveform is observed on Doppler US. This article details the imaging findings and clinical presentations of DVT mimics, organized by these classifications. This information may help radiologists make more accurate diagnoses, enabling patients to receive appropriate treatment in a timely manner.
4.Ultrasound evaluation of clinical mimics of deep vein thrombosis: essential insights for radiologists in interpretation
Dongsuk IM ; Lyo Min KWON ; Sun Young PARK ; Min Su PARK ; Won Ju HONG
Ultrasonography 2025;44(3):171-188
Ultrasonography (US) is a sensitive and radiation-free technique for diagnosing deep vein thrombosis (DVT). Therefore, when DVT is clinically suspected but not detected on US, radiologists should consider a range of alternative differential diagnoses. This review article presents the imaging findings of clinical conditions that mimic DVT, which can be distinguished using a multimodal radiologic approach. Additionally, DVT mimics can be categorized into two groups based on whether a flat or normal waveform is observed on Doppler US. This article details the imaging findings and clinical presentations of DVT mimics, organized by these classifications. This information may help radiologists make more accurate diagnoses, enabling patients to receive appropriate treatment in a timely manner.
5.Ultrasound evaluation of clinical mimics of deep vein thrombosis: essential insights for radiologists in interpretation
Dongsuk IM ; Lyo Min KWON ; Sun Young PARK ; Min Su PARK ; Won Ju HONG
Ultrasonography 2025;44(3):171-188
Ultrasonography (US) is a sensitive and radiation-free technique for diagnosing deep vein thrombosis (DVT). Therefore, when DVT is clinically suspected but not detected on US, radiologists should consider a range of alternative differential diagnoses. This review article presents the imaging findings of clinical conditions that mimic DVT, which can be distinguished using a multimodal radiologic approach. Additionally, DVT mimics can be categorized into two groups based on whether a flat or normal waveform is observed on Doppler US. This article details the imaging findings and clinical presentations of DVT mimics, organized by these classifications. This information may help radiologists make more accurate diagnoses, enabling patients to receive appropriate treatment in a timely manner.
6.Telpegfilgrastim for chemotherapy-induced neutropenia in breast cancer: A multicenter, randomized, phase 3 study.
Yuankai SHI ; Qingyuan ZHANG ; Junsheng WANG ; Zhong OUYANG ; Tienan YI ; Jiazhuan MEI ; Xinshuai WANG ; Zhidong PEI ; Tao SUN ; Junheng BAI ; Shundong CANG ; Yarong LI ; Guohong FU ; Tianjiang MA ; Huaqiu SHI ; Jinping LIU ; Xiaojia WANG ; Hongrui NIU ; Yanzhen GUO ; Shengyu ZHOU ; Li SUN
Chinese Medical Journal 2025;138(4):496-498
7.A retrospective cohort study of the efficacy and safety of oral azvudine versus nirmatrelvir/ritonavir in elderly hospitalized COVID-19 patients aged over 60 years.
Bo YU ; Haiyu WANG ; Guangming LI ; Junyi SUN ; Hong LUO ; Mengzhao YANG ; Yanyang ZHANG ; Ruihan LIU ; Ming CHENG ; Shixi ZHANG ; Guotao LI ; Ling WANG ; Guowu QIAN ; Donghua ZHANG ; Silin LI ; Quancheng KAN ; Jiandong JIANG ; Zhigang REN
Acta Pharmaceutica Sinica B 2025;15(3):1333-1343
Azvudine and nirmatrelvir/ritonavir (Paxlovid) are recommended for COVID-19 treatment in China, but their safety and efficacy in the elderly population are not fully known. In this multicenter, retrospective, cohort study, we identified 5131 elderly hospitalized COVID-19 patients from 32,864 COVID-19 patients admitted to nine hospitals in Henan Province, China, from December 5, 2022, to January 31, 2023. The primary outcome was all-cause death, and the secondary outcome was composite disease progression. Propensity score matching (PSM) was performed to control for confounding factors, including demographics, vaccination status, comorbidities, and laboratory tests. After 2:1 PSM, 1786 elderly patients receiving azvudine and 893 elderly patients receiving Paxlovid were included. Kaplan-Meier and Cox regression analyses revealed that compared with Paxlovid group, azvudine could significantly reduce the risk of all-cause death (log-rank P = 0.002; HR: 0.71, 95% CI: 0.573-0.883, P = 0.002), but there was no difference in composite disease progression (log-rank P = 0.52; HR: 1.05, 95% CI: 0.877-1.260, P = 0.588). Four sensitivity analyses verified the robustness of above results. Subgroup analysis suggested that a greater benefit of azvudine over Paxlovid was observed in elderly patients with primary malignant tumors (P for interaction = 0.005, HR: 0.32, 95% CI: 0.18-0.57) compared to patients without primary malignant tumors. Safety analysis revealed that azvudine treatment had a lower incidence of adverse events and higher lymphocyte levels than Paxlovid treatment. In conclusion, azvudine treatment is not inferior to Paxlovid treatment in terms of all-cause death, composite disease progression and adverse events in elderly hospitalized COVID-19 patients.
8.Investigating the prevalence and clinical symptoms of non-convulsive seizures in emergency department patients with unexplained altered consciousness using real-time portable continuous electroencephalographic monitoring
Soo Wook KIM ; Won Soek YANG ; Jin Hyouk KIM ; Sang Ook HA ; Young Sun PARK
Journal of the Korean Society of Emergency Medicine 2024;35(5):353-363
Objective:
A wireless electroencephalography (EEG) headset was applied to patients with an unclear etiology of an altered mental status suspected of non-convulsive seizures in the emergency department.
Methods:
The study included patients who presented to the emergency department with an altered mental status from January 1, 2020, to April 30, 2023. The patients with abnormal findings in brain imaging or those with typical seizure movement were excluded. Real-time portable continuous EEG monitoring was conducted on patients with persistent altered consciousness despite receiving conservative treatments and showing improvement in vital signs and blood tests within 3 hours. The baseline characteristics, degree of consciousness alteration and neurological symptoms, initial clinical diagnosis, EEG findings, and medications used in cases where epileptiform discharges were examined. The clinical outcomes were analyzed retrospectively.
Results:
Among 26 patients, six patients showed epileptiform discharges. The final diagnoses included uremic encephalopathy (n=2), septic encephalopathy due to pneumonia (n=1), urinary tract infection (n=1), diabetic ketoacidosis (n=1), and mental change only (n=1). The associated symptoms were myoclonus in three patients and abnormal eye movements in two patients.
Conclusion
In cases where the causes of altered mental status remain unexplained despite appropriate evaluations and treatments, particularly when accompanied by myoclonus or abnormal eye movements, it is crucial to consider the possibility of non-convulsive seizures and promptly perform an EEG to differentiate and diagnose the underlying condition, even if initial tests and treatments have been performed.
9.Effects of X-ray volume imaging registration methods on position verification for radiotherapy in treatment of middle/lower-segment esophageal cancer
Haojia LIU ; Huitao WANG ; Hongwei XU ; Anping ZHENG ; Xiaodong SUN ; Jinfeng ZHU
Chinese Journal of Radiological Health 2023;32(1):52-57
Objective To compare the set up errors derived from different registration methods of the X-ray volume imaging (XVI) system for radiotherapy in the treatment of middle/lower-segment esophageal cancer, and to provide a reference for radiation treatment of esophageal cancer. Methods We randomly selected 63 patients with middle/lower-segment esophageal cancer, and obtained their reconstructed XVI images at the first therapy to perform automatic registration with gray-value and bone registration methods. We acquired and compared the three translation errors (along x [left to right], y [head to feet], and z [front to back] axes) and three rotation errors (around the x, y, and z axes) derived from the two registration methods. Results Gray-value registration had significantly smaller translation errors along the x and z axes than bone registration (x azes t = −2.78, z azes t = −2.15, P < 0.05), but there was no significant difference along the y axes (P > 0.05). The rotation errors around the three axes were all smaller than 1°, and were smaller with gray-value registration than with bone registration, but without significant differences (P > 0.05). Conclusion We recommend gray-value registration for radiotherapy in the treatment of middle/lower-segment esophageal cancer. Manual verification or fine-tuning is recommended after automatic registration in clinical practice. Besides translation errors, rotation errors should also be paid attention to.
10.Palinacousis after Cerebral Venous Thrombosis in the Temporoparietal Lobe
Euihyun KIM ; Na Hee KIM ; Myun KIM ; Chaery JEON ; In Hee KWAK ; Mi Sun OH ; Chi-Hun KIM
Journal of the Korean Neurological Association 2023;41(4):324-327
Palinacousis is a rare auditory phenomenon characterized by the persistence of sounds beyond their actual duration. It has been associated with various brain conditions such as stroke, tumor, and seizure in the temporoparietal lobe. We present a case report of a 43-yearold man who developed palinacousis following cerebral venous thrombosis and seizure with lesions including the left auditory cortex. This case highlights the intriguing relationship between cerebral venous infarction, seizure, and the development of palinacousis in specific brain regions.


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