Grifola frondosa (Dicks. Fr.) S.F.Gray. was for the first time isolated and fruifully cultivated on mixed substrate in §µ L¹t, Vietnam for preservation of fungal gene resources and for suppling of nutritional foods and pharmaceutical material
Agaricales ; Antineoplastic Agents ; Fungi

The squamule button mushroom Agaricus blazei Murrill was fruifully cultivated in Da Lat, VietNam, under similar procedure at large scales with white button mushroom A. bisporus, giving lower biological efficiency (biomass of fresh fruibodies harvested per unit of dry composts used). The prefectful development of fruibodies was described and a minireview on their medicine - food value was discussed
Agaricales ; Antineoplastic Agents

A minireview on current status in systematics of the genus Lentinula Pegler was presented addition of distinct collection of Cao Bang stain of shiitake from Vietnam, that were described as a new geographical race with morphologically specific characters intermediating between L. edodes and L. lateritia. Furthermore, non fertile hybrids (basidiosporeless lines) obtained by nonospore-crossing between Cao Bang strain and strains of l. edodes from Japan support so distinct differentiations, that Cao Bang shiitake would be suggested even at the rank of biologically distinct species
Antineoplastic Agents ; Lentinula ; Agaricales

For the first time, the natural specimens of Abalone Oyster mushroom Pleurotus pulmonarius (Fr.) Quel. were collected and comparatively identified in Central Highland, South Vietnam. Pure isolation and fruitful cultivation of this mushroom were conducted for preservation of fungal gene resources and supply of precious foods and pharmaceutical material
Antineoplastic Agents ; Genes, Fungal

Schizophyllum commune (Fr:Fr.) rick were collected from various regions in Vietnam, thoroughly described and isolated for fruitful cultivations and mycelial fermentations to supply precious material for antitumor preparations
Antineoplastic Agents ; Schizophyllum ; Fungi

Mucuna birdwoodiana Tutch. is a new medicinal plant to the flora of Vietnam. The new species was found to the flora of Vietnam. It was identified as mucuna birdwoodiana Tutch. The plant grows wildly in ThanhHoa province. The plant is use similarly to Ke huyet dang (Spathobus suberectus Dunn.).
Antineoplastic Agents ; Plants, Medicinal

The plants of the genus Phyllanthus (Euphorbiaceae) are distributed in most tropical and subtropical regions of world. This plant has been long used as a traditional medicine to treat problems such as stomach, intestinal infections, kidney and urinary bladder disturbances, diabetes, and hepatitis B. There has been considerable interest in these plants in recent years. This review discusses the antiviral and anticancer aspects of Phyllanthus species. Scientific studies have demonstrated that extracts and purified isolated compounds (flavonoids, lignans, phenols, and terpenes) obtained from these plants possess antiviral effects against herpes simplex (HSV) and dengue virus infections (DENV). These observations are associated with the disruption of essential proteins needed during viral cycle, thus halting the viral replication. In addition, the Phyllanthus species have also been shown to exert inhibitory effects against selected cancers types. In these studies anti-proliferative, anti-metastatic, anti-angiogenic effects and induced apoptosis of human cancers cell lines were observed. These may be explained by the disruption of multiple survival pathways and differential protein expression. CONLCUSION:As a conclusion, tThe Phyllanthus plant possesses multiple medicinal properties, including antiviral and anticancer activities which may potentially be used as a medicinal source for many disease locally.
Antineoplastic Agents ; Dengue

Aims: The attention for new and effective anticancer drugs but less toxic is increasing over time. Streptomyces is the most important and well-known source of their bioactive compound production with useful bioactivities. This work aimed for evaluation of the anticancer potential of methanolic extract of Streptomyces sp. strain KSF 83 against non-cancerous cell lines (CCD-841-CoN), breast (MCF-7, MDA-MB-231) and colon cancer cell lines (HT-29, HCT-116). Methodology and results: The characteristic of the strain KSF 83 was identified by morphology and 16S rRNA sequencing and results confirmed that the strain belonged to the genus of Streptomyces. The crude substance was produced via submerged fermentation from the strain and methanol solvent was used to extract the culture filtrate. Methanolic extract possessed low toxicity against CCD-841-CoN with only 18% of inhibition activity at the 400 µg/mL. Among all tested cancer cells, the methanolic extract was able to inhibit the growth of all cancer cells tested with MCF-7 was the highest anticancer activity recorded. The methanolic extract also exhibited cytotoxicity in a range of EC50 of 65.79 μg/mL to 262.40 μg/mL. This study revealed the anticancer potential of Streptomyces sp. strain KSF 83, which could be sources of prospective anticancer drugs against breast and colon cancer. Conclusion, significance and impact of study The extract of KSF 83 was non-toxic toward normal cell lines and able to inhibit the growth of breast and cancer cell lines, thus it can be a potential source of the anticancer drug against breast and colon cancer.
Antineoplastic Agents--pharmacology ; Streptomyces

In vitro and invivo anticancer activity of cisplatin on experimantal model of cancer. In comparison with the controls, a single dose of Cisplatin of 8 mg/kg of animal body weight was injected in mouse. The preparation inhibited completely the formation of ascitic fluid in mice bearing sarcoma 180. the biomass of the sarcome was minished by 99,5%, with anti – tumor effcacy (+++) according to H. to kawa scale (1989). Cisplatin (produced by the central babrik of planta medic) blocked 68% of mitotic index of cancer cells. The increase in life span of cancer mice treated by cisplatin was 130% more than that of the controls (39,2 days versus 17 days) 70% of treated mice survived after 27 days
Antineoplastic Agents ; Pharmaceutical Preparations ; Neoplasms

Besides low molecular compounds against morphological and cytotoxic change that were extracted from Chinese herbal medicines, some high molecular compounds have been extracted and used for treatment of malignant disease. Among which, polysaccharides and ribosome-inactivating proteins are specially noticed. Polysaccharides from fungal and high-class plants with immunostimulation effects have been tested in experimentation and in clinical. Ribosome-inactivating proteins are a group of proteins inhibited standard protein synthesis in nucleus by attacking 28S ribosome RNA. These substances have been tested in experimental and clinical trials for treating tumor by single compound and combined with antibodies
Drugs, Chinese Herbal ; Antineoplastic Agents