educational ; Antibiotics

Therapeutic ; Antibiotics

Alpinia laosensis Gagnep. is a specific plant of Laos, but it also grows in some districts of Vietnamese – Laos frontier. The different components of rhizome of Alpinia laosensis Gagnep. was extracted in order of the solvents: The ether petroleum, the ethylacetate and the methanol. The antifungal compound 3-(p-acetylphenyl) – 3-methylcarboxyl – 1-propen was isolated from residue of the ether petroleum by method bioassay – guided
Antibiotics, Antifungal ; Rhizome ; plants

This study emulates the findings of a study by Zaidi et al. in Pakistan in which the authors reported the similar success story (2). Similar success has been reported in a randomized trial in Africa that found treatment of pneumonia in the neonate by either oral penicillin or procaine benzylpenicillin and gentamycin to be as equally effective (3). The author is confident that this method of combining of both inpatient and outpatient administration of antibiotics for neonatal sepsis will be successful in our local setting due to high quality medical care that is offered by both government and private medical facilities here with many health clinics supporting the local hospitals.
Neonatal Sepsis ; Antibiotics

Drug's quality on the market must conform to standards of manufacturer based on Vietnamese Pharmacopoeia III. This report deals with standard about dissolubility of some antibiotic pill products of Pharmaceutical Factory X circulating on the market, such as amoxiciline, penicilline, cloramphenicol, ciprifloxacine, .... (10 types) by Dissolution test method, showed that there were 9 products (90%) attained standards Vietnamese Pharmacopoeia III. This is a impressed result of Vietnamese Pharmaceutical Industry in enhancing drug's quality
Solubility ; Antibiotics, Antifungal ; Quality Control

The emergence of allergy caused by Pingyangmycin is rare. A case of allergy caused by minidose and low concentration Pingyangmycin was reported in this article.
Antibiotics, Antineoplastic ; Bleomycin ; analogs & derivatives ; Humans ; Hypersensitivity

Antibiotic use must carefully and must exactly consider according to indication and combined exactly method and disease. To against antibiotic resistance, urgent methods is needed such as drugs used exactly disease, sufficient dose and enough time. For physicians, should careful if prescribe antibiotic, don't use new drug if older drug still effective, review antibiotic resistance to choose exactly, preservation obey exact standards, limited using antibiotic for cattle and poultry
Antibiotics, Antifungal ; Pharmaceutical Preparations ; Delivery of Health Care

For infections in infants and children, the successful antibiotic treatment depends primarily on rapid diagnosis of the disease, identification of pathogenic microorganisms, and appropriate application of specialized pharmacokinetic and pharmacodynamic knowledge of antibiotics in children. In infants and children, the absorption, distribution, metabolism, and excretion of drugs may differ considerably in comparison with adults. Because of known toxicity, certain drugs such as chloramphenicol in high doses, the sulfonamides, and tetracycline should not be used in neonates. In this article, we describe these peculiarities of children and discuss the proper use of antibiotics in children.
Antibiotics/therapeutic use* ; Antibiotics/pharmacokinetics ; Antibiotics/metabolism ; Antibiotics/administration & dosage ; Child, Preschool ; Dose-Response Relationship, Drug ; Human ; Infant ; Pediatrics/methods* ; Time Factors

Antibiotic-loaded bone cement has been used as prophylaxis against infection in total joint replacement surgery. Its effect on the mechanical strength of cement is a major concern as high dose of antibiotic was associated with a significant reduction in mechanical strength of bone cement. However, the cut-off antibiotic that weakens the mechanical strength of cement remains to be determined. This study was undertaken to observe the changes in the mechanical properties of bone cement with gradual increments of Cefuroxime antibiotic. Cefuroxime at different doses: 0, 1.5, 3.0 and 4.5gm were added to a packet of 40gm bone cement (Simplex P) and study samples were prepared by using third generation cementing technique. Mechanical impact, flexural and tensile strength were tested on each sample. Significant impact and tensile strength reduction were observed after addition of 4.5 gm of Cefuroxime. However, flexural strength was significantly reduced at a lower dose of 3.0 gm. The maximum dose of Cefuroxime to be safely added to 40mg Surgical Simplex P is 1.5gm when third generation cementing technique is used. Further study is needed to determine whether it is an effective dose as regards to microbiological parameters.
Skeletal bone ; Cefuroxime ; Antibiotics ; meter ; Reduction (chemical)

Mesosomes of Staphylococcus aureus ATCC 25923 treated with antibiotics were examined morphologically under the electron microscope. The Transmission Electron Microscope Rapid Method was used to eliminate the artifacts due to sample processing. Mesosomes were seen in all the antibiotic treated bacteria and not in the control group. The main factor that contributes to the formation of mesosomes in the bacteria was the mode of action of the antibiotics. The continuous cytoplasmic membrane with infolding (mesosomes) as in the S. aureus ATCC 25923 is therefore confirmed as a definite pattern of membrane organization in gram positive bacteria assaulted by amikacin, gentamicin, ciprofloxacin, vancomycin and oxacillin antibiotics. Our preliminary results show oxacillin and vancomycin treated bacteria seemed to have deeper and more mesosomes than those treated with amikacin, gentamicin and ciprofloxacin. Further research is needed to ascertain whether the deep invagination and the number of mesosomes formed is associated with the types of antibiotic used.
Antibiotics ; seconds ; Mesosome ; Staphylococcus aureus ; Bacterial