The chitosan produced from carapace of shrimp was used for resecrch on acute anti-inflammatory and analgesic effects. The experimental results showed that:- Chitosan in dose of 100mg/kg and 200mg/kg by subcutaneous route to rats had acute anti-inflammatory effect with the same level, but by oral route, chitosan in dose of 400 mg/kg had not yet. -Chitosan with concentration (1%) had the biggest analgesic effect.
chitosan ; Analgesics ; Anti-Inflammatory Agents

Healthy rats with weight of 120-180 g were randomly divided into 4 groups. They tested the anti-acute inflamatory activity of T1 (3 -methoxy 4 hydroxy-5 bromobenzylidien para bromo anilin) and T2 (3-methoxy 4 hydroxy-5 nitrobenzylidien p-nitro anilin). The results have shown that T1 had a significant antiinflamatory activity after 2 h and 4 h of the test but had no antiflamatory activity after 6 h of the test comparing with the control. While the anti-inflamatory activity of T2 was not different from this in the control. This study concluded that the anti-inflamatory activity of derivatives of 5 bromo vanilin was better than this of derivatives of 5 -nitroanilin.
Anti-Inflammatory Agents ; analogs & derivatives

Two models: experimental traumatic edema (I) and 1% carrageenin-induced edema (II), were developed on rats for the study of the anti-inflammatory effects of drugs, I being superior to II as for the efficacity and appropriate treatment. The model for the study of the analgesic effect was developed by pressing on rat legs. Of the various prescriptions prepared from a traditional massage tincture, the formulations of 5% propylene glycol and emulgel were more effective in anti-inflammation and analgesia than the tincture itself.
Massage ; Anti-Inflammatory Agents ; Analgesics

In vitro, flavonoids from Lonicera japonica Thunb flavonoids stimulate the catalysis of hydrolysis starch. This stimulating effect depended on the concentration of Lonicera japonica flavonoid but their in vitro stimulations weren’t strong. The anti-inflammatory effects were stronger when combining flavonoid with -amylase on dextran-induced edema mouse legs. So active catalysis stimulation of -amylase could be associated with anti-inflammation process; with unclear mechanisms. This result suggested the need of further research of anti-inflammatory drugs according to combine of traditional medicine and anti-inflammatory enzyme
Flavonoids ; Anti-Inflammatory Agents ; Lonicera

Clnical and endoscopic manifestations of gastro-duodenal injuries in 178 patients caused by nonsteroidal anti-inflammatory drugs (NSAID) were compared with these of 84 patients without treatment of NSAID. We concluded that abnomal rate in gastro-duodenal endoscopy is 86.0 % in the group treated by NSAID. Gastric injury rate is 80.9 %, including 22.5% of gastric ulcer (p<0.01). Duodenal injury rate is 29.2 %. including 22.5% of duodenal ulcer (p<0.01). Clinical features: epigastric pain rate is 42.7%; abdominal distention is 11.8%. These symploms are useful in predicting gastrointestinal injuries. These lesions more likely severe if the patient have following factors: above 60 years old; alcoholism, smosking, using NSAIDs for long time, using high dose of the NSAIDs. There is not relation between endoscopic manifestations, type of rheumatic disease and HP infections.
Anti-Inflammatory Agents, Peptic Ulcer

Researching in test mouse. Result: In vivo, Honeysuckle flower have a acute anti-inflammatory effect when used alone as well as its combination with alpha-CT. In vitro, honeysuckle flower have a stimulate effect of the activity alpha-CT. The successful combination of decoction and honeysuckle flower (flavonoid) with alpha-CT(in vitro and in vivo) took a little part in studying the anti-inflammatory mechanism of honeysuckle flower with alpha-CT. The synergic effect of above two active element induced which give satisfactory anti-inflammatory effect, which was equivalent to some of modern medicine of use to anti-inflammatory drug.
Flowers ; Anti-Inflammatory Agents ; Flavonoids

Perform research synthetic glucosamine hydrochloride (Glu-1) and anti-inflammatory activity of Glu-1 on test mouse. Evaluate effect of inhibit beriberi inflame acute, effect of inhibit increase degree of imbibe artery hang bowel, inhibit development of experimental chronic inflame and effect of relieve writhe pain of Glu-1. Result: synthesized Glu-1 and determined structure by modern, high degree of accuracy method. Glu-1 showed significant anti-inflammatory ability compared with diclofenac, which is being used in the same experimental conditions.
Glucosamine ; Anti-Inflammatory Agents ; Salts

Dariers disease is inherited as an autosomal dominant trait and characterized by follicular pruritic hyperkeratotic papules. The onset is usually in late childhood and the course of the disease is chronic and slowly progressive in most cases. Dariers disease is refractory to treatment with most conventional keratolytics and anti-inflammatory agents. To date, oral and topical retinoid products have been the mainstay therapy for this population, but local as well as systemic side effects often limit their effectiveness. We present a case of localized Dariers disease which responded promptly to the topical application of adapalene 0.1% gel without side effects. A review of treatment for Dariers disease also is presented.
Anti-Inflammatory Agents ; Darier Disease* ; Adapalene

NSAIDs user has a risk of gastrointestinal toxicity. Endoscopy is often used in studies of NSAIDs to determine the extent to which the studied drug causes gastrointestinal damage. Most patients taking NSAIDs will develop acute superficial damage to the gastric mucosa, including haemorrhages and erosions. However, in many cases there are no symptoms. The main role of endoscopy is to diagnose gastroduodenal damage in patients who have signs and symptoms e.g. dyspepsia, upper abdominal pain... NSAIDs with improved gastrointestinal tolerability, such as meloxicam, may now reduce the incidents of adverse gastrointestinal events.
Anti-Inflammatory Agents, Non-Steroidal ; Enteritis

Studies during 1970-1980 reported that 40% patients used the NAIDs suffered the gastrointestinal complication, commonly upper abdominal pain, dyspepsia; heart-burn and sour at least one time in the first week of drug administration occurred in 29% patients. About a haft million patients suffered the severe complications, even death due to the gastrointestinal toxicity of the drug. The discovering 2 subclasses of the cyclooxygenase enzyme COX and COX1 and new NSAIDs that have selective activity on the COX2 helped reducing significantly side effects of these valuable drugs. However any drug is always considered double way knife.
Anti-Inflammatory Agents, Non-Steroidal ; Pharmaceutical Preparations