1.Contribution of HBV and HCV infection in mortality of B cell non-Hodgkin’s lymphoma subjects
Myagmarjav B ; Anir E ; Delgerbat B ; Khishigjargal B ; Myadagsuren S ; Erdenetsogt D ; Dahgwahdorj Ya ; Davaadorj D ; Naranjargal D
Mongolian Medical Sciences 2020;191(1):19-25
Background:
The correlation between hepatitis B, C viruses (HBV, HCV) and B cell non-Hodgkin’s Lymphoma
(B-NHL) and reducing mortality have been studied extensively worldwide
Objective:
In this study, we aimed to determine the prevalence of HBsAg and anti-HCV positive cases among
B-NHL patients and its influence on the survival rate of these patients (on ≤12 months).
Materials and Methods:
We have done a retrospective analysis on patients who aged over 20 years and newly diagnosed at
the Hematology Center of the First State Hospital between 2015-2018. The patients’ information was
collected according the study ethics. We divided the patients into 2 groups, survival rate less than
12 months (≤12 months) and survival rate more than 13 months (≥13 months), and compared them
regarding age, gender, seroprevalence, and Ann-Arbor stage.
Results:
Overall, 226 patients (107 males and 119 females with average 54.4) were enrolled in the study.
There were 15% HBsAg positive and 41,6% anti-HCV positive cases, while Baatarkhuu et al. (2005)
reported (11.8%, 15.6%; p=0.160, p<0.00001) and Bekhbold et al. (2013) reported (11.1%, 10.6%;
p=0.055, p<0.00001) in apparently healthy population. Moreover, anti-HCV positive cases among
B-NHL patients were higher (p<0.00001) than those (27%) among hepatocellular carcinoma (HCC)
patients and same (p=0.404) with those (39%) among liver cirrhosis patients in Mongolia (Bolormaa
et al., 2009). Furthermore, 72.0% of all subjects in III-IV stages was accounted for HBsAg, anti-HCV
positive group which had ≤12 months, while 52.1% of them was accounted for HBsAg, anti-HCV
positive group which had ≥13 months and was statistical significantly lower (p=0.02).
Conclusion
Anti-HCV and HBsAg positive cases might contribute to survival rate with the B-NHL patients
diagnosed at the III-IV stages. HCV prevalence among B-NHL subjects was significantly higher than
that among the general population prevalence and was same with anti-HCV positive prevalence
among the HCC.
2.Comparative study of subcutaneous fat area and visceral fat area among healthy and metabolic syndrome patients
Munkh-Erdene U ; Odmaa T ; Solongo Ts ; Ganchimeg S ; Egshiglen G ; Anir B ; Ariunaa A ; Navchaa G ; Tulgaa S ; Munkhtsetseg J
Mongolian Journal of Health Sciences 2025;86(2):36-41
Background:
Obesity, especially central obesity, is a risk factor for non-communicable chronic diseases such as dyslipidemia,
type 2 diabetes mellitus (T2DM), cardiovascular diseases (CVD), and metabolic syndrome (MetS).
Aim:
Study the association between the subcutaneous fat area (SFA) and visceral fat area (VFA) with lipid metabolism
parameters in adults with MetS.
Materials and Methods:
Data from 1511 participants who visited the ‘NURA Mongolia’ Ai Health screening center
between September 2023 and February 2024, including general information, DEXA (Dual X-ray Absorptiometry), and
biochemical analysis results, were used. Metabolic syndrome (MeS) was assessed based on the harmonizing criteria 2009
(≥3 criteria). VFA and SFA were categorized into four groups using quartiles (Q1-Q4). Statistical analysis was performed
using SPSS v26, including T-tests, multiple logistic regression (OR, 95% CI), and ROC (AUC) analysis.
Results:
The average age of the participants was 30.5±3.9 years, with a BMI of 25.1 kg/m², and 49.5% were male. The
group with MetS (n=531) had significantly higher levels of VFA and SFA compared to the group that rated their health as
relatively healthy and had no clinical diagnosis (n=979) (control group) (p<0.0001), with males showing higher VFA and
females showing higher SFA (p<0.0001). The Q4 group for VFA had a significant association with MetS in males (4.611,
95% CI=2.394–9.591) and females (2.253, 95% CI=1.097-3.912) (p<0.001). Logistic regression analysis showed that increased
VFA was more strongly associated with MetS in males (β=0.325, p<0.0001) and females (β=0.338, p<0.003) than
BMI. The AUC for predicting MetS was 0.790 (95% CI=0.750-0.831) for VFA and 0.401 (95% CI=0.351-0.451) for SFA,
with all results being statistically significant (p<0.001). VFA had a higher predictive value compared to other markers.
Conclusion
In healthy men with metabolic syndrome, VFA is more prominently defined, while SFA is higher in healthy
women. Since VFA is a better predictor of metabolic syndrome than SFA, it increases the risk of diseases such as cardiovascular
diseases and type 2 diabetes in men, whereas SFA in women serves as a protective factor.