Background: many studies showed that obesity rate was significantly higher in women than in men and 60-80% of overweight/obesity caused by diet. Hanoi and Ho Chi Minh City were two of 10 provinces that had the highest rates of obesity. Objectives: to determine the actual rate of overweight/obesity and describe some related factors among Hanoians aged 50-59. Subjectives and Method: a cross sectional survey within a case-control study. The study was carried out in 14 wards under 7 districts of urban Hanoi. Body fat percentage was measured by machine Omron (Japan). Overweight/obesity evaluations were based on classification scales of WHO 1998 and IDI&WPRO 2000. Results: the mean rate of overweight/obesity was 23.1% (26.2% in women vs. 21.9% in men). The rate of women with waist to hip ratio >0.85 (39.83%) was higher than that in male (29.38%). Proportions of body fat percentage greater than 30% were 58.40% in female and 40.06% in male. Overweight/obesity was closely related with sedentary lifestyle, such as spending less time for exercise and sports, high food expenditures, etc. It was found that people with overweight or obese family members were 3 times at risk of overweight/obesity higher /than others. That rates of overweight/obese people with elevated level of biomarkers were composed of 48.99% with high blood cholesterol (>5.2mmol/l); 9.69% with blood glucose (\ufffd?.0mmol/l); especially 65.33% with high triglyceride (>1.7mmol/l); 7.22% with low HDL-C (<1.15 mmol/l); and 8.23% with high LDL-C (\ufffd?.00mmol/l). Conclusions: rate of overweight/obesity among Hanoians aged 50-59 was relatively high. Some related factors were described: waist to hip ratio, body fat percentage, sedentary lifestyle, such as spending less time for exercise and sports, high food expenditures, etc.
Overweight/epidemiology ; Obesity/epidemiology ; Risk Factors ; Middle Aged ;

Background: Fragile X Syndrome (FXS) is the most common cause of inherited mental retardation. The absence of Fragile X Mental Retardation (FMRP) in Fragile X syndrome changes other proteins. Objective: To detect changes of glycoprotein in human serum of Fragile X syndrome. Subject and methods: Affinity chromatography with lectin concanavalin A (ConA) used to receive glycoprotein. The collected glycoprotein was then separated using 2-D electrophoresis. The protein spots were further excised, trypsin digested, and analyzed by nano LC couple with ESI-MS/MS and identified by MASCOT v1.8 software. Results and conclusion: 5 glycoproteins showed the different expression levels in the serum of Fragile X syndrome. Haptoglobin, Ig-J were increased and ceruloplasmin, transferring, Ig kappa were decreased. Using affinity chromatography with lectin concanavalin A (ConA), glycoprotein was received and divided on 2 ways electrokinetic chromatography. The mixture protein was identified with a reliability of 99.5% by 2 ways liquid chromatography combined with continuous spectrum mass.
Fragile X syndrome ; Fragile X Mental Retardation ; proteomics

Background: HIV (human immunodeficiency virus) is the virus that causes AIDS. This virus is passed from one person to another through blood-to-blood and sexual contact. In addition, infected pregnant women can pass HIV to their baby during pregnancy or delivery, as well as through breast-feeding. Objectives:To study the CCR5- 32 and SDF 1-3 A allelic frequence in the HIV -1 infected mothers and their children. Subjects and method: Amplificated on CCR5 and SDF1 gene by PCR and restriction of this fragment length polymorphisme (RLFP) assay for detection of the mutated gene by EcoR1 and Hpall. Results: No mutation of CCR5 was found but only mutation identified at the SDF1 gene. Mutation identified at the SDF1 gene of the mother was: homozygote 2.7% (accounted for 2/37 cases), heterozygote 40.54% (accounted for 15/37 cases) and at the children: homozygote 5.4% (accounted for 1/37 cases), heterozygote 45.95% (accounted for 17/37 cases). The CCR5 chemokin receptor is a co-receptor for M trofic HIV-1 strains, which predominate in the early stage of the HIV disease and SDF-1 natural ligand for the CXCR4 reception. The mutation of these genes protect from HIV-1 infection (slow progression).\r\n', u'Conclusion: It\u2019s necessary to find the mutation of CCR5 and CCR2b related the progression of HIV patients. \r\n', u'
HIV-1/ metabolism ; Receptors ; CCR5