Introduction: Uncontrolled hypertension is a leading cause of death worldwide and self-care is one of the essential management strategies. However, data regarding the psychometric properties of self-care instruments in the Indonesian context is lacking. This study aims to validate the Hypertension Self-care Profile (HBP SCP) instrument in the Indonesia version. Methods: A forward-backward translation technique was used for the Hypertension (HBP SCP) questionnaire. This questionnaire had three domains namely motivation, self-efficacy, and behavior. It was completed by a total of 191 respondents and the survey was conducted from September to December 2021 in the Health Primary Care Bandung West Java, Indonesia. The Cronbach’s alpha was used to test the reliability scale, the content validity index was assessed by five experts, and item inter-correlation was analyzed to test the total items. Results: The results showed that the content validity index was in the excellent category with a value of 0.89. The Cronbach’s alpha coefficient was 0.875, indicating satisfactory internal consistency. Furthermore, the total items correlation had a significance value of 0.05 (df = N-2) for the three scales namely 0.353-0.742, 0.302- 0.642, and 0.237-0.649 for motivation, self-efficacy, and behavior, respectively. Conclusion: The Indonesian version of the Hypertension HBP SCP instrument is valid and reliable.