OBJECTIVES: To determine the prevalence and identify the types of Nasopharyngeal Carcinoma (NPCA) among patients with nasopharyngeal mass seen at a tertiary university training hospital in  the  Philippines  from  January  2006  -  July  2012  and  identify  possible  factors associated  with nasopharyngeal carcinoma.
METHODS: A  retrospective  cross-sectional  study  was  performed  at  a  tertiary  university  training hospital among cases (n=179) seen with nasopharyngeal mass at the ENT outpatient department. Histopathology results and patient medical charts were collected and reviewed after IRB approval. The  age  at  diagnosis,  sex,  place  of  residence,  occupation  and  chief  complaint  was  compared among patients with positive histopathology of NPCA only.
 Design: Retrospective, cross sectional study
 Setting: Tertiary Private University Training Hospital
 Participants: One hundred seventy nine (179) patients with nasopharyngeal mass
RESULTS: Ninety six (54%) cases with nasopharyngeal mass seen at the ENT outpatient department were positive for nasopharyngeal malignancy. The remaining 83 (46%) cases with nasopharyngeal mass had a benign histopathology. NPCA was more common among males (58%) than females (42%).  The  most  common  form  of  NPCA  was  non-keratinizing  undifferentiated  NPCA  (47%) followed by poorly differentiated squamous cell carcinoma in 18 (19%). The most common chief complaint was a neck mass, followed by decreased hearing.
CONCLUSION: There  was  a  higher  proportion  of  nasopharyngeal  malignancy  among  male patients  with  nasopharyngeal  mass,  and  the  most  common  chief  complaint  was  a  neck  mass. Future  research  should  integrate  data  with  other  hospital  institutions  to  obtain  more  accurate demographic  data  of  the  local  prevalence  of  NPCA.  A  detailed  record  of  the  ethnicity,  diet, occupation, smoking history and family history of cases should be obtained to correlate possible risk factors of NPCA among patients with nasopharyngeal mass in our setting.

Human ; Male ; Female ; Middle Aged ; Adult ; Young Adult ; Carcinoma ; Epidemiology ; Prevalence

OBJECTIVE: To report a case of a 12-year-old boy with Necrotizing Lymphadenitis (Kikuchi-Fujimoto disease) presenting as lymphadenitis secondary to multiple diagnosis.

 

METHODS:

Design : Case Report

Setting: Tertiary Private Hospital

Patient: One

 

RESULTS: A 12-year-old boy consulted for two-month history of cervical lymphadenopathy with the underlying cause remaining unclear despite multiple consults, diagnosis and medical treatment. Lymphoma was considered and excision biopsy with further investigations confirmed a diagnosis of Kikuchi-Fujimoto disease. Supportive management was given with no recurrence of symptoms noted on 18 months of follow up. 

 

CONCLUSION:  Kikuchi-Fujimoto disease in this case was a diagnosis of exclusion. Even with a proper history and physical examination, experts in otolaryngology can be misled to manage this case as malignant. Awareness of the disease and appropriate examinations including immunohistochemistry are important for a timely diagnosis and proper intervention.

 

KEYWORDS: lympadenitis; Kikuchi-Fujimoto disease; lymphoma; cervical lymph nodes

Human ; Male ; Child Preschool (a Child Between The Ages Of 2 And 5) ; Histiocytic Necrotizing Lymphadenitis ; Lymphoma