1.Challenges in the management of concomitant TB arthritis and AVN in a lupus patient with adverse drug reaction to anti-Koch's medications.
Tee Kenneth D. ; Magbitang Angeline-Therese D. ; Tee Michael L.
Philippine Journal of Internal Medicine 2014;52(4):189-192
BACKGROUND: Non traumatic osteonecrosis also known as avascular necrosis (AVN),and tuberculous arthritis (TB arthritis)most commonly present as chronic monoarticular conditions. Corticosteroid intake is known to predispose individuals to the development of these two conditions.
In AVN, corticosteroid remains to be the most common cause that leads to a final common pathway of disrupting blood supply to segments of bone causing cell death. In TB arthritis, corticosteroid renders a patient relatively immunocompromised predisposing to this extrapulmonary infection.
The incidence of tubercular osteonecrosis in a patient with systemic lupus erythematosus is rare. A review of literature only showed one case report of tubercular osteonecrosis diagnosed by aspiration cytology. Since tuberculosis (TB) is a destructive but curable disease, early diagnosis and treatment are essential.
OBJECTIVE: To present a case of tubercular osteonecrosis in a patient with systemic lupus erythematosus treated with anti-Koch's regimen and iloprost infusion.
CASE: A 27-year old Filipino female who was diagnosed with lupus nephritis and underwent three days methylprednisolone pulse therapy. Lupus nephritis improved and was clinically inactive for two years. She developed insidious onset of intermittent pain on her left knee, associated with swelling for four months with subsequent right hip pain of one week duration. MRI of the left knee showed osteonecrosis and arthritis. Radiograph of the right hip showed osteonecrosis. She underwent arthrocentesis of the left knee and the synovial fluid tested positive for tuberculosis by PCR. We started the patient on quadruple anti-Koch's regimen together with iloprost infusion which afforded clinical improvement.
CONCLUSION: To our knowledge, this is the first reported case of a lupus patient with concomitant polyarticular osteonecrosis complicated by monoarticular tuberculous arthritis. Medical treatment, while it may be complicated by adverse drug events, is effective in symptomatic treatment, but a multidisciplinary approach is suggested for optimal outcome.
Human ; Female ; Adult ; Adrenal Cortex Hormones ; Arthritis ; Arthrocentesis ; Cell Death ; Early Diagnosis ; Iloprost ; Incidence ; Lupus Erythematosus, Systemic ; Lupus Nephritis ; Methylprednisolone ; Osteonecrosis ; Pain ; Polymerase Chain Reaction ; Tuberculosis, Osteoarticular
2.Prevalence of metabolic syndrome in Filipino patients with gout in a tertiary hospital.
Dianongco Maria Lucilla G. ; Magbitang Angeline-Therese D. ; Salido Evelyn O.
Philippine Journal of Internal Medicine 2014;52(1):1-4
OBJECTIVE: The aim of the study is to determine the prevalence of metabolic syndrome (MS) in Filipino patients with gout and know the specific component that is predominant in this population.
METHODS: Patients who are diagnosed with gout based on the American College of Rheumatology (ACR) criteria, at least 20 years old, attending the outpatient rheumatology clinic of a tertiary hospital from March 2012 to December 2012 and willing to sign written informed consent were included in the study. The following information was collected: demographic and disease characteristics, blood pressure, body mass index, waist circumference, triglycerides, HDL, and fasting blood sugar. MS was defined according to the revised NCEP/ATP III criteria using the WHO Asia-Pacific obesity criteria. Results were reported in means and proportion.
RESULTS: Sixty-three patients were included in the study. The mean age of onset and at time of diagnosis of gout were 47.3 years and 52.9 years, respectively. At the time of the study, the average duration of gout was five to 10 years. The male to female ratio was 6:1. The prevalence of MS was 47.6% (30/63) with male to female ratio of 5:1.The prevalence of abdominal obesity was 39.7%, hypertension 36.5%, low HDL 31.7%, high triglycerides 30.2%, and diabetes mellitus 14.3%.
CONCLUSION:The prevalence of MS in this subset of Filipino patients with gout was 47.6%. Its most common component was abdominal obesity found in 39.7% of cases. This is an area of intervention that needs to be addressed in the care of these patients.
Human ; Male ; Female ; Middle Aged ; Adult ; Metabolic Syndrome X ; Obesity, Abdominal ; Obesity ; Hdl-triglyceride ; Triglycerides ; Diabetes Mellitus ; Lipoproteins, Hdl ; Hypertension ; Adenosine Triphosphate
3.A three-month follow up of musculoskeletal manifestions in chikungunya fever.
Gutierrez-Rubio Anna Kristina ; Magbitang Angeline-Therese D. ; Penserga Ester G.
Philippine Journal of Internal Medicine 2014;52(1):1-5
BACKGROUND: Chikungunya virus (CHIKV) is a mosquito- borne alphavirus of the family Togaviridae transmitted to humans by the Aedes spp. mosquitoes, causing Chikungunya Fever (CHIKF).
OBJECTIVE: This study aims to describe the course and outcome of musculoskeletal (MSK) manifestations in patients with CHIKF seen over a three-month period.
DESIGN: This is a prospective descriptive study. Seventy patients with fever, rash, and arthritis seen at the University of the Philippines-Philippine General Hospital and private arthritis clinics were collected from August - December 2012. Demographics and course of arthritis were described.
RESULTS: Seventy patients, 53 (68.6%) female, with a mean age of 39.2 ±13.50 were diagnosed with CHIKF. All cases were from the Metropolitan Manila area. Of these, 15 (21.4%) had family members affected. Twenty-four patients (34.3%) were either employed or students. The most common presenting symptoms were fever (94.3%), arthritis or athralgia (98.6%), and rash (87.1%). The most common joint areas involved were the ankles (60.0%), the wrists (40.0%) and the small joints of the hand (51.4%). Twenty-seven (47.3%) had symmetric arthritis. Thirty- seven cases (52.9%) had arthralgia or arthritis for at least six weeks. By the end of the follow-up period, only four (5.7%) had persistent musculoskeletal symptoms. Age and sex were not found to be factors in determining chronicity of arthritic symptoms (p = 0.104 and p=0.58 respectively). Of the seventy patients, 31 (44. 3%) were confirmed cases of CHIKF-- 29 had (+) CHIKV IgM by ELISA, and two had (+) CHIKV PCR. Twenty- one (67.7%) had persistent arthritis of at least six weeks. Treatment consisted of continuous NSAIDs for at least two weeks and some received steroids. In this subgroup, age and sex were not shown to correlate with chronic arthritis (p=0.47 and p=0.05 respectively).
CONCLUSION: This report on a recent outbreak of CHIKF showed the classic triad of fever, rash, and arthritis. There was no correlation between age and chronicity of arthritic symptoms. Sex, likewise, did not appear to influence chronicity. The disease occurred in family clusters. Patients required continuous treatment with NSAIDs and some had to be given steroids. Most cases resolved by 12 weeks.
Human ; Male ; Female ; Middle Aged ; Adult ; Chikungunya Fever ; Chikungunya Virus ; Togaviridae ; Anti-inflammatory Agents, Non-steroidal ; Arthralgia ; Arthritis ; Exanthema ; Enzyme-linked Immunosorbent Assay
4.In-hospital outcomes of methylprednisolone pulse therapy in the treatment of systemic lupus erythematosus.
Magbitang Angeline-Therese D. ; Rubio Anna Kristina Gutierrez ; Salido Evelyn Osio
Philippine Journal of Internal Medicine 2014;52(1):1-7
BACKGROUND: Methylprednisolone Pulse Therapy (MPPT) is standard of care in the management of severe systemic lupus erythematosus (SLE). This treatment, though, is considered a double-edged sword due to its life-threatening adverse effects. Renal disease, liver disease and high dose of the drug are factors proposed to adversely affect outcomes of patients treated with MPPT. Despite the widely accepted use of MPPT, there are no reports describing the outcomes from its use among Filipinos with SLE.
OBJECTIVE: To determine the in-hospital outcomes of patients with SLE treated with MPPT and to identify factors associated with adverse outcomes.
GENERAL STUDY DESIGN: Retrospective
POPULATION: Adult patients with SLE who were admitted in Philippine General Hospital and underwent MPPT from January 2008 to December 2012.
METHODS: Patient demographics, disease characteristics on admission, indications for MPPT and in-hospital outcomes were extracted.
ANALYSIS: Chi-square test and Fisher's exact test were used to elicit association of population characteristics to outcomes.
RESULTS: Forty-two patients with SLE who underwent MPPT were included. Majority are females (98%) and most (60%) underwent MPPT within one year of SLE diagnosis. High disease activity is seen at the time
of MPPT with a mean Mex-SLEDAI score of 14.69. Infection (83%) is the most common comorbidity. Anemia, hypoalbuminemia and significant proteinuria are the most common laboratory abnormalities. The top indication for MPPT is nephritis (83.3%). The dose received by the majority (66.7%) is one gram/day for three days, which is a high dose.
Improvement rate is 76% but the in-hospital complication rate is 64% and mortality rate is 21%. Patients with in-hospital complications have significantly lower absolute lymphocyte count (p=0.013), serum albumin (p=0.04) and greater 24-hour proteinuria (p=0.04) at baseline. High-dose MPPT is significantly associated with in-hospital complications (p=0.04) but not mortality. Nephritis (p= 0.04) and low platelet counts at baseline (p=0.01) are associated with mortality.
CONCLUSION: In this population, there is a high rate of improvement of lupus disease activity when MPPT is used but there is a corresponding high rate of in-hospital complications and mortality. High dose of MPPT seems to be associated with increased in- hospital complication, while nephritis and low platelet count showed a probable association with mortality. Further studies on a larger cohort are needed. For now, the findings of this study may be helpful in developing guidelines on the use of MPPT among Filipino patients with SLE.
Human ; Male ; Female ; Adult ; Hypoalbuminemia ; Serum Albumin ; Lupus Erythematosus, Systemic ; Nephritis ; Kidney Diseases ; Proteinuria ; Anemia ; Liver Diseases ; Lymphocyte Count ; Methylprednisolone
5.Endometrial tuberculosis causing amenorrhea and abnormal uterine bleeding in a lupus patient treated with cyclophosphamide.
Magbitang Angeline-Therese D. ; Racaza Geraldine Z. ; Reyes Bernadette Heizel M.
Philippine Journal of Internal Medicine 2014;52(1):1-4
BACKGROUND: Amenorrhea may occur in patients with lupus treated with cyclophosphamide. This is commonly attributed to primary ovarian failure leading to infertility -- a possible complication of cyclophosphamide. Urogenital tuberculosis (TB) can be a rare cause of amenorrhea and infertility in lupus patients.
OBJECTIVE: To present a case of endometrial TB causing amenorrhea and abnormal uterine bleeding in a patient with lupus nephritis treated with cyclophosphamide.
CASE: A 32-year-old Filipino female, who was diagnosed with lupus nephritis, was managed with high dose steroid and intravenous (IV) cyclophosphamide. Lupus nephritis improved with treatment, but she subsequently developed amenorrhea and vaginal spotting for two months. Symptoms were initially attributed to premature ovarian failure due to cyclophosphamide.Gynecologic examination showed thickened endometrium with normal ovaries and uterus on ultrasound. Dilatation and curettage was performed. Histopathology of endometrial curetting revealed chronic granulomatous endometritis with Langhans giant cells. Endometrial TB was diagnosed, and anti-Koch's therapy was started. The patient showed a favourable response, with resumption of normal menstruation after only the first month of treatment.
CONCLUSION: This paper emphasizes the importance of considering a wide range of differential diagnosis for gynecologic symptoms in patients with lupus. Tuberculosis should be considered in areas of high endemicity
Human ; Female ; Adult ; Primary Ovarian Insufficiency ; Lupus Nephritis ; Endometritis ; Amenorrhea ; Giant Cells, Langhans ; Cyclophosphamide ; Menopause, Premature ; Tuberculosis, Urogenital ; Infertility ; Uterine Hemorrhage
6.Takayasu Arteritis Presenting as Bilateral Ocular Ischemic Syndrome
Ramon B. LARRAZABAL JR ; Harold Henrison C. CHIU ; Angeline Therese MAGBITANG-SANTIAGO
Vascular Specialist International 2020;36(3):163-169
A 26-year-old female came in with progressive blurring of vision. She had developed memory loss and complained of headache, significant weight loss, and exertional left calf pain after prolonged walking. Pertinent physical findings included light perception on visual acuity examination, and the brachial and radial pulses of both arms were not appreciable. Thoracic and abdominal aortic imaging by computed tomography with contrast revealed narrowing along the thoracic aorta and its branches. Carotid Doppler showed bilaterally thickened walls in the common carotid arteries, with near total occlusion of the left carotid artery. These findings were consistent with bilateral ocular ischemic syndrome in Takayasu arteritis. She was given methylprednisolone 500 mg intravenously daily for 3 days with noted improvement in vision. She was discharged and showed improvement on prednisone 35 mg/day and aspirin 80 mg/day. On follow-up two weeks post-discharge, she reported being able to see silhouettes of persons and objects.
7.Assessment of malnutrition risk among patients with Rheumatic Diseases in the Rheumatology Clinic of a Tertiary Training Government Hospital in the Philippines using the Malnutrition Universal Screening Tool
Juneth Ria Limgenco-Hipe ; Evelyn Salido ; Angeline-Therese Magbitang ; Allan Corpuz ; Ana Hernandez ; Kenneth Tee
Philippine Journal of Internal Medicine 2018;56(1):19-22
Introduction:
Malnutrition is a frequently neglected problem among patients with chronic illnesses. It correlates with decreased functionality and quality of life and increased morbidity and mortality. The prevalence of malnutrition in chronic rheumatologic conditions ranges from 15-24%. There is an unfounded suspicion that malnutrition is common among Filipino patients with rheumatic diseases. The study will bridge this knowledge gap and pave the way for a more holistic approach in the care of rheumatic diseases. The researchers aim too assess the risk of malnutrition among patients of the rheumatology clinic of the Philippine General Hospital.
Methods:
This is a cross-sectional study. After getting informed consent, we collected data on demographics and disease characteristics and administered the Malnutrition Universal Screening Tool (MUST). We classified patients according to malnutrition risk and managed accordingly.
Results:
One hundred eighty-two patients are included (86% are female), with mean age of 45 years old (SD=16.65). The majority (54%) has less than collegiate level of education and 76% are below minimum wage earners. Twelve percent are smokers and 16% are alcohol beverage drinkers. Thirty-nine percent have systemic lupus erythematosus (SLE), 17% have rheumatoid arthritis (RA) and 16% have osteoarthritis (OA). The average duration of illness is 75 months. Ten percent are at high risk and 18% are at moderate risk of malnutrition. Six percent of SLE patients have high risk and 24% at moderate risk while 19% and 16% of patients with RA, respectively, have high and moderate risk of malnutrition. Among patients with OA, 6.9 % have high and 3.4% have moderate risk of malnutrition.
Conclusion
Using the MUST routinely identifies patients at risk of malnutrition. Twenty-eight percent of patients at the rheumatology clinics of the Philippine General Hospital have moderate to high risk of malnutrition. Identifying those at risk of malnutrition allows for timely intervention and optimal care.
Rheumatic Diseases
;
Malnutrition
;
Philippines
8.Assessment of cognitive impairment in Systemic Lupus Erythematosus using the Mini-Mental Status Exam and the Montreal Cognitive Assessment Test-Filipino Version
Allan D. Corpuz ; Angeline Therese D. Magbitang ; Ana Teresa S. Hernandez ; Kenneth D. Tee ; Evelyn Osio-Salido ; Bernadette Heizel Manapat-Reyes
Philippine Journal of Internal Medicine 2018;56(2):82-88
Introduction:
Cognitive impairment (CI) in patients with systemic lupus erythematosus (SLE) presents with or without overt signs of central nervous involvement. The prevalence of CI is variable, ranging from 19-80%. It is often overlooked, leading to high healthcare costs and productivity loss. The usual tools for detection are expensive, time-consuming and not locally available. Detection of CI using the Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment Test (MoCA) is more clinically relevant and practical. The objectives of this study are to determine the prevalence of CI in SLE patients using MMSE/MoCA, to determine the degree of impairment in the different cognitive domains, and to characterize patients with CI in terms of disease activity, education, and employment.
Methods:
This is a cross-sectional study of 62 SLE patients, 19 years or older, at a rheumatology clinic. Demographic and disease characteristics were collected. The validated Filipino versions of the MMSE/MoCA test were administered. Descriptive and non-parametric statistics were applied.
Results:
Most patients are female (96.77%), below collegiate level of education (58.06%), and unemployed (70.97%). Mean disease duration is 8.92 (SD±7.03) years. Mean age at diagnosis is 28 (SD±10.30) years. Hypertension is the most common co-morbidity. Most have low lupus disease activity or are in remission (80.65%). Most are on prednisone (72.58%), with an average dose of 11.88mg/day (SD±10.66). The prevalence of CI is 38.71% (MMSE-P) and 77.42% (MoCA-P). The presence of CI is not related to educational level, employment, and disease activity.
Conclusion
Cognitive impairment (CI) is common in this cohort of SLE patients. Disease activity, level of education and employment do not seem to affect its occurrence. The MMSE-P and MoCA-P are rapid tools to assess the presence of CI and should be used in clinical practice to improve the quality of care for patients with lupus.
Lupus Erythematosus, Systemic
;
Cognitive Dysfunction
;
Mental Status and Dementia Tests
;
Philippines