Background: Breast cancer, chemotherapy and endocrine treatment are risk factors for osteoporosis. Dual-energy x-ray absorptiometry (DXA) remains the gold standard in the diagnosis of osteoporosis. A quantitative computed tomography (QCT) with a bone mineral density analysis software on the whole abdomen CT may be used for screening osteoporosis without additional radiation exposure or cost. Objective: To determine the accuracy of QCT in detecting osteoporosis among breast cancer patients using DXA as gold standard. Methods: This is a cross-sectional analytic study of 76 Filipino women with breast cancer who underwent both DXA and whole abdomen CT scans. The DXA measurements were obtained using Lunar iDXA manufactured by GE Healthcare while the QCT measurements were made using the BMD analysis software available in the Philips Extended Brilliance Workspace post-processing system. Results: Out of the 76 Filipino women with breast cancer, 92% were menopausal women with mean age of 58.9 (SD 8.7) years, 69.7% had IDCA and 94.7% had mastectomy. Majority had normal BMD (44.7%), 34.2% had osteopenia and 21.1% had osteoporosis based on DXA. QCT has 90% (95% CI: 55.5-99.8) sensitivity, 63.6% (95% CI: 30.1- 89.1) specificity, 69.2% (95% CI: 50.1-83.5) PPV, 87.5 (95% CI:50.8-97.9) NPV, 2.5 (95% CI:1.1-5.6) LR(+) and 0.16 (95% CI:0.02-1.06) LR (-). Conclusion The prevalence of osteoporosis and osteopenia among Filipino women with breast cancer was 21.1% and 34.2%. The sensitivity and specificity of QCT in detecting osteoporosis was 90% and 63.6%.
Osteoporosis ; Bone Diseases, Metabolic ; Breast Neoplasms