1.Association of serum magnesium and distal symmetric peripheral neuropathy among Filipino patients with Type 2 Diabetes Mellitus
Marion B. Sarigumba ; Andrea Marie M. Oliva ; Ma. Jocelyn C. Isidro
Philippine Journal of Internal Medicine 2024;62(1):283-290
Objective:
This study aims to determine the association of serum magnesium with distal symmetric peripheral
neuropathy among persons with type 2 diabetes mellitus (DM).
Methodology:
A cross-sectional analytical study among adult Filipinos with Type 2 DM. Logistic regression was used to
determine the association of serum magnesium with DSPN diagnosed by the Michigan Neuropathy Screening Instrument.
The null hypothesis was rejected at 0.05α-level of significance.
Results:
The average serum magnesium levels were similar between those with versus without DSPN (2.06 ± 0.32 vs 2.05
± 0.23, p = 0.873); the same was seen for corrected magnesium. There is insufficient evidence to demonstrate a significant
statistical difference between those with and without DSPN in relation to glycemic control (HbA1c and FBS). Likewise, there
is no significant statistical correlation between serum magnesium levels with HbA1c, FBS, BMI, or duration of diabetes.
Conclusion
This present study could not demonstrate any association between DSPN and serum magnesium, even after
adjusting for age, sex, and comorbidity.
Magnesium
;
Diabetic Neuropathies
2.Pre-operative glycosylated hemoglobin level and fasting blood sugar as markers for risk of acute kidney injury in the immediate post-operative period among type 2 diabetic patients after elective abdominal surgery.
Lisa Angelica V. EVANGELISTA ; Maria Jocelyn C. ISIDRO ; Andrea Marie M. OLIVA ; Mary Rose Y. BISQUERA
Philippine Journal of Internal Medicine 2022;60(1):13-18
Objectives: The study aimed to identify whether pre-operative glycosylated hemoglobin level (HbA1c) and fasting blood sugar (FBS) can be used as markers for the development of acute kidney injury (AKI) in the immediate post-operative period of type 2 diabetic patients after elective abdominal surgery.
Methods: This retrospective cohort pilot study included seventy-four diabetic patients who underwent elective abdominal surgery from 2015 to 2018. HbA1c and FBS, demographic data, comorbidities, type and indication of surgery, and treatment history were correlated with the development of AKI using logistic regression analysis.
Results: In this cohort, 12% of subjects developed AKI. Univariate and multivariate logistic regression analysis, however, showed that neither HbA1c and FBS nor other studied factors were predictive for the occurrence of AKI (OR 2.55, p= 0.26 and OR 0.64, p= 0.72 respectively).
Conclusion: Pre-operative HbA1c and one-time FBS values in diabetic patients undergoing elective abdominal surgery procedures were not statistically predictive of AKI in the present data. However, the observed trend towards the risk of AKI among the elevated HbA1c subset of patients should drive further studies with a greater sample size and of a prospective nature looking at other metabolic factors contributing to AKI.
Pre-operative Glycosylated Hemoglobin Level ; Fasting Blood Sugar ; Acute Kidney Injury