1.Median Survival Time of Endometrial Cancer Patients with Lymphovascular Invasion at the Hospital Universiti Sains Malaysia
Wan Adnan Wan Nor Asyikeen ; Ab Hamid Siti-Azrin ; Nur Asyilla Che Jalil ; Anani Aila Mat Zin ; Nor Hayati Othman
Malaysian Journal of Medical Sciences 2016;23(6):44-51
Background: Endometrial cancer is the most common gynaecologic malignancy among
females worldwide. The purpose of this study was to determine the median survival time of
endometrial cancer patients at the Hospital Universiti Sains Malaysia (USM).
Methods: A list of 121 endometrial cancer cases registered at Hospital USM between 2000
until 2011 was retrospectively reviewed. The survival time of the endometrial cancer patients
was estimated by Kaplan-Meier survival analysis. Log-rank tests were performed to compare the
survival of the patients based on socio-demographics and clinical presentation.
Results: Only 108 patients, 87.0%, were included who were of Malay ethnicity. Previous
history included menopause in 67.6% of patients and diabetes mellitus in 39.8% of patients;
additionally, 63.4% of patients were nulliparous. Tumour staging was as follows: 24.5% stage
I, 10.8% stage II, 26.5% stage III and 38.2% stage IV. The overall median survival time of the
endometrial cancer patients was 70.20 months (95% confidence interval (CI): 51.79, 88.61). The
significant factors were age, the presence of lymphovascular invasion and treatment received.
Conclusion: The overall survival of endometrial cancer was low. A prospective study
needs to be carried out to discover more effective and accurate tests for the early detection of
endometrial cancer.
2.Coughing on palpation: A rare complication of vagal schwannoma
Zabrina Marnel Samarakkody ; Khairil Amir Sayuti ; Anani Aila Mat Zin ; Wan Nor Najmiyah Wan Abdul Wahab ; Irfan Mohamad
Malaysian Family Physician 2018;13(3):40-43
Cervical vagal schwannoma is an uncommon, benign neoplasm. It is usually asymptomatic and
presents as a painless, palpable mass in the neck. However, large schwannomas can cause dysphagia,
dysphonia or dyspnea as a result of compression. We report a case of an extremely rare complication
of vagal schwannoma in which neck palpation induced the patient to cough. As the patient refused
any surgical intervention, conservative management was used.
3.A Systematic Review of the Role of Mitochondria in Cleft Pathology: A Forgotten General?
Rabiatul Adawiyah Mohamad Noor ; Wan Azman Wan Sulaiman ; Anani Aila Mat Zin ; Nurul Syazana Mohamad Shah
Archives of Orofacial Sciences 2022;17(1):21-30
ABSTRACT
Orofacial clefts (OFC) are one of the most common birth defects that affects the lip, palate, or lip
and palate of an infant. The deterioration of clefts is multifactorial involving multiple genes, various
interactions from environmental factor and most forgotten, mitochondrial abnormality. The aim of this
review is to highlight the importance of mitochondrial activity related to non-syndromic OFC deformity.
Despite its important role in cells, the study on mitochondrial activity in cleft pathology was scarce and
almost forgotten compared to other genetic investigations. This systematic review was completed based
on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. The
literature search was done via the following databases: Google Scholar, Pubmed and Scopus with a total
of nine studies of mitochondrial abnormalities were included. We hypothesise that mitochondria play an
important role in early craniofacial development. A decreased in its function or activity may result in cleft
lip formation. Hence, we would like to shed light on the remarkable role of mitochondria activity in the
pathogenesis of non-syndromic OFC.
Mitochondria--pathology
;
DNA, Mitochondrial
;
Cleft Lip
;
Cleft Palate
4.Diagnostic Pitfall in Fine Needle Aspiration Cytology of Pilomatrixoma with Unusual Clinical Presentation
Omar Alzallal ; Anani Aila Mat Zin ; Hasni Mahayidin ; Ikmal Hisyam Bakrin
Malaysian Journal of Medicine and Health Sciences 2021;17(No.4):416-418
Pilomatrixoma (PMX) is a benign skin adnexal tumour with matrical differentiation. It frequently presents as a painless and slow growing solitary skin nodule primarily at the head, face and neck regions. Although there is increasing
understanding on the clinical presentations and morphological features of PMX, difficulties are still expected in establishing the clinical and cytological diagnosis. We report a young girl who presented with a painless post-auricular
swelling for one year with sudden increased in size. Computed Tomography (CT) scan and fine needle aspiration
cytology (FNAC) findings were suggestive of a malignancy. Diagnosis of PMX was established and confirmed by tissue histopathological examination. The purpose of this study is to demonstrate the diagnostic pitfall of PMX in FNAC
specimens, especially in patients with unusual clinical presentations.