OBJECTIVE: This randomized, single-blind, two-arm controlled study compared the efficacy, safety, and tolerability of an intravaginal suppository preparation containing metronidazole 750mg + miconazole 200mg (Neopenotran Forte) with another vaginal preparation containing metronidazole 500 mg + nystatin 10000 IU (Flagystatin) in the treatment of bacterial vaginosis (BV), candidal and trichomonial vulvovaginitis (CVV, TV), mixed vaginitis and in the prevention of secondary candidal vulvovaginitis.

MATERIALS AND METHODS: Women ages 18-45 years with chief complaints of abnormal vaginal discharge or vaginal/vulvar itching were examined and microbiologic confirmation of BV, VVC, TV or mixed infection was made. They were then randomly assigned to receive either treatment once daily (nightly) for 7 days. A total of 261 subjects had evaluable clinical and microbiological findings at the end of the study. Test of cure by Amsel criteria and Nugent score were performed twice after treatment.

RESULTS: The overall test revealed that microbiological cure rate is significantly different between the two treatment groups.

CONCLUSION: The odds of being cured microbiologically is 2.35 times more in the metronidazole 750mg + miconazole nitrate 200mg group compared to the metronidazole 500 mg + nystatin 10000 IU group. However, no significant difference in the clinical cure between the two groups was found. Both drugs are safe and convenient to use.

Human ; Female ; Adult ; Young Adult ; Vaginosis, Bacterial ; Candidiasis, Vulvovaginal ; Suppositories ; Vaginitis

Tuberculosis (TB) has been known to be nearly as old as human history. In 2017 WHO Global TB report, in the Philippines the incidence rate was 554/100,000. Tuberculosis contributed to a significant proportion of the global burden of disease, and has significant effect on maternal and perinatal outcomes. Congenital tuberculosis is a rare complication in utero of tuberculosis infection with reported incidence of only 358 cases in literature up to 1995 and another 110 cases reported between 1995 and 2009. This paper discusses the case of a 17-year-old young primigravida, diagnosed with tuberculosis few months before pregnancy and treated with first-line quadruple anti-TB regimen. However, she developed jaundice with elevated liver enzymes, hence, the medications were discontinued. Re-challenge of anti-TB drugs were done, however, the patient persistently showed signs and symptoms of adverse drug reactions to antiTB drugs. At 29 weeks age of gestation, she was admitted for control of preterm labor. Congenital anomaly scanning showed hepatomegaly, intraabdominal abscess, and pseudocyst formation, suggestive of congenital TB. Because of this, the anti- TB drugs were re-introduced despite the elevated liver enzymes with closer monitoring of liver function tests. However, despite aggressive tocolysis, the patient eventually delivered preterm to a live baby boy with poor outcome. The baby expired on the 18th day of life.
Pregnancy ; Female ; Tuberculosis

This is the case of a 19 year-old woman who presented with recurrent vulvovaginal, cervical and oral ulcers. In addition to steroid treatment, she underwent surgical wound debridement followed by topical treatment of the lesions with honey which showed favorable results. The aim of this case report is to present the wound healing properties of honey since there are no previously documented case on honey as a treatment in Behcet’s ulcers.
Honey ; Ulcer