Burkitt's lymphoma is a highly aggressive and proliferative type of mature B cell nonHodgkin's lymphoma. Therapeutic strategies for Burkitt's lymphoma remain a challenge because of significant toxicities and poor prognosis. Further studies investigating the underlying molecular mechanisms of the carcinogenesis, chemotherapy and drug resistance are needed to improve the treatment of Burkitt's lymphoma.

OBJECTIVE:To analyze the cost of three schemes in treatment of unstable angina pectoris METHODS:88 patients with unstable angina pectoris were divided into three groups:group Ⅰ was given isosorbide,asprin,nifedipine and nitroglycerin;group Ⅱ was given isosorbide,asprin,nifedipine,nitroglycerin and red sage injection and group Ⅲ was given isosorbide,asprin,nifedipine,nitroglycerin and puerarin;then using pharmacoeconomic method,cost-effectiveness analysis was carried out RESULTS:The efficacy in the group Ⅱ and group Ⅲ was higher than that in group Ⅰ(P0 05),and the E/C(effectiveness/cost) of the three groups were 15 98,18 02 and 33 40 respectively Compared with group Ⅰ,?C/?E of group Ⅱ and Ⅲ were 24 66,83 90 respectively;Compared with group Ⅱ,?C/?E of group Ⅲ was 643 60 CONCLUSION:The scheme for group Ⅱ is the best one

Breast cancer is the most common malignant tumor in women, bone related events (SREs), such as bone pain, pathological fracture and so on, can affect seriously the quality of life.Experts in Chinese Anti-Cancer Association, Committee of Breast Cancer Society (CACA-CBCS) discussed the Consensus on the Diagnosis and Treatment of Bone Metastasis and Skeletal Related Diseases in Breast Cancer (2014 version), here reflections on several hot issues were explored.

Objective To investigate the early diagnostic value and cost‐effectiveness analysis of common inflammatory markers , including interleukin‐6 (IL‐6 ) , procalcitonin (PCT ) and C‐reactive protein (CRP) in cirrhotic patients with infectious fever .Methods From January 2012 to January 2015 , cirrhotic patients hospitalized in liver center of First Affiliated Hospital ,Fujian Medical University who were excluded with community‐acquired infections and developed fever 48 hours after admission were selected .According to having infection or not ,they were divided into infection group and non‐infection group .White blood cell count (WBC) ,neutrophil percentage (N % ) ,IL‐6 ,PCT ,and CRP at admission (baseline) and at the time point of fever were recorded .The diagnostic threshold of WBC ,N% ,IL‐6 , PCT ,and CRP for infectious fever in cirrhotic patients were analyzed by receiver operating characteristic analysis curve (ROC) .The cost‐effectiveness (C/E) of those biomarkers were compared .Results A total of 299 cases were enrolled ,with 162 in infection group and 137 in non‐infection group .Two hundred and forty‐four were male and 55 were female .The mean age was 55 .1 ± 13 .0 years .Upon the onset of fever , WBC ,N% ,IL‐6 ,PCT ,and CRP of infection group were all significantly higher than those of non‐infection group (all P< 0 .05) .The area under the curve of IL‐6 for infectious fever was 0 .939 (95% CI 0 .910 - 0 .968) ,which was significantly higher than those of PCT and CRP (Z = 5 .718 and 9 .048 , respectively ,both P< 0 .01) .The optimal cut‐off point of IL‐6 was 184 .5 ng/L ,with the sensitivity of 85 .2% and specificity of 94 .9% .C/E value was 38 .3 for N% ,and 51 .2 for CRP . However ,both specificity and specificity of CRP and N % were low .C/E value was 389 .0 for PCT and 63 .4 for IL‐6 .IL‐6 had the highest sensitivity (85 .2% ) and specificity (94 .9% ) among all the biomarkers .Conclusions Compared to PCT and CRP ,IL‐6 has the highest sensitivity and specificity with lower cost‐effectiveness for diagnosis of infectious fever in cirrhotic patients .

[ ABSTRACT] AIM:To observed the correlation between Th17 cell level and the symptom severity and prognostic factors of chronic obstructive pulmonary disease ( COPD) , and to explore the clinical application value of Th17 cell level in assessing the prognosis of patients with COPD.METHODS:The patients with diagnosed COPD ( n=110) in our hospital during May 2013 to December 2014, and 40 healthy subjects were enrolled in the study.According to the Global Initiative for Chronic Obstructive Lung Disease ( GOLD) , the COPD patients were divided into group A ( low risk, less symptoms) , group B (low risk, more symptoms), group C (high risk, less symptoms) and group D (high risk, more symptoms), which were given inhaled corticosteroid/long-acting β2 agonist or corticosteroid/long-acting β2 agonist +long-acting anti-muscarinic agent treatment for 3 months.The proportion of Th17 cells, cytokines (IL-17 and IL-6), the COPD assessment test ( CAT) score, age, body mass index, pulmonary function and the times of acute exacerbation of COPD in previous 1 year were observed before and after treatment.The correlation analysis between the level of Th17 cells and other clinical characteristics was performed.RESULTS:Th17 cell, IL-17 and IL-6 levels in COPD group were significantly higher than those in control group (P<0.05).With the increase in the severity of COPD symptoms, Th17 cells, cytokines (IL-17 and IL-6) and CAT score in groups B and D were significantly higher than those in groups A and C (P<0.05).The univariate analysis showed that the levels of Th17 cells in groups B and D before treatment were positively correlated with the CAT score (P<0.05), which were negatively correlated with FEV1, FEV1%Pred, FVC and FVC%Pred.The levels of Th17 cells were not correlated with the CAT score, FEV1 , FEV1%Pred, FVC and FVC%Pred in groups A and C.The levels of Th17 cells after treatment were positively correlated with the CAT score, which were negatively correlated with FEV1 , FEV1%Pred, FVC and FVC%Pred (P<0.05).CONCLUSION:The peripheral Th17 cell level has a good correlation with IL-17, IL-6, CAT score and pulmonary function in COPD patients, suggesting a potential value to predict the symptom severity and prognosis of COPD.

The mechanisms underlying early neurological deterioration (END) after ischemic stroke are not clear.There are no reliable predictive factors and effective preventive measures for END.The glutamatemediated excitotoxicity plays a very important role in the cascade reaction of ischemic events.High level of glutamate in plasma is one of the important predictors for END.Studies have shown that the polymorphism in the promoter of the excitatory amino acid transporter-2 gene is a potential cause for individual susceptibility to END.Some therapeutic strategies of interrupting the glutamatergic pathways may be as the strategies of intervention END.

Intracranial atherosclerotic stenosis mostly occurs in Asians,blacks and Hispanicsis,which is the most important reason for the occurrence and recurrence of ischemic stroke.The current studies mainly concentrate on the aspect of the relationship between the intracranial atherosclerotic stenosis and the traditional risk factors.With the development of genetic technology,the relationship between the genetic factors and intracranial atherosclerotic stenosis has also received increasing attention.This article reviews the advances in research on the traditional risk factors for intraeranial atherosclerotic stenosis and genetic research.

Objective To observe the effects of hemodialysis on nutritional status and water balance in newly diagnosed end-stage renal disease(ESRD)patients.Methods Thirty newly diagnosed ESRD patients who accepted hemodialysis for the first time were included in the study;body water balance was analyzed by bioelectric impedance analysis(BIA)method and nutritional status were evaluated by BIA,anthropometry and blood biochemical indicators.Results Total body water,extracellular fluid,intracellular fluid,normalized total body water,normalized extracellular fluid,normalized intracellular fluid were decreased significantly after 3 months of hemodialysis(P

Objective To investigate the activity of gastrocnemius muscle after acellular nerve transplantation with microencapsulated peripheral nerve tissue to repair sciatic nerve gap in dogs. Methods Twelve dogs were selected and divided randomly into four groups with three in each. Both sciatic nerves of the dogs in group A were cut and chemically extracted to make acellular nerves. Acellular nerves were transplanted into the dogs of groups B and C to bridge 30 mm sciatic nerve gaps, and additionally microencapsulated peripheral nerve were added in group B. Autograft was used for repairing the defects in group D. The motor function of operated limbs were observed regularly after operation. Six months after operation, motor conduction velocity of the specimens of sciatic grafting nerve segment were observed, and the gastrocnemius muscle of both sides were obtained and performed succinic dehydrogenase (SDH), synaptophysin (SYP) and motor end plate histochemical staining, and sciatic nerve 1 cm from distal end stoma were obtained and underwent Masson, Luxol fast blue and NF200 staining. Results All the dogs in groups B, C and D were involved in the results analysis without loss. Image analysis indicated the optical density and the cross section area of gastrocnemius muscle, area and optical density of synaptophysin, area and optical density of motor end plate in group B showed statistically significant difference compared with those in group C, but no significant difference with those in group D. The results of motor function recovery of operated-limb, electrophysiological examination and morphologic observations of sciatic nerve were all consistent with the detections of gastrocnemius muscle. Conclusion The gastrocnemius muscle may be again innerved by nerve, and the muscle atrophy is significantly alleviated after acellular nerve transplantation with microencapsulated peripheral nerve tissue for repairing sciatic nerve gap. The regeneration of nerve was better after the combined transplantation than only acellular nerve transplantation, so the combination of acellular nerve and microencapsulated peripheral nerve tissue may be a useful substitute of autograft for nerve repair.

Pingyangmycin was produced by Pingyangnesin sp No. 74 which was isolated from mud at Pingyang, Zhejiang China. The structure and properties of Pingyangmycin are the same as those of bleomycin A-g. Pingyangtnycin-induced cellular DNA breakage was observed in this experiment. DNA breakage in vitro was found by agarose gel electrophoresis and UV fluoresene photography after ethidium bromide staining 0. 5ug cellular DNA incubated with a series of drug concentrations for 2h and with a series of drug exposure times at a dose of 200 ug/ml. The mininal concentration and exposure time of DNA breakage is 5 ug/ml and 10 min. DNA molecule was observed under electron microscope with basic protein mounting technique. The natural spiral DNA long strand (X =5.95 um+1.95)was cut down into short DNA fragments ("X =0.75 n.m+0.24)by 10 ug/ml drug for 2h_ The length of untreated DNA is significantly longer than that of the drug treated one(P