Health Personnel ; psychology ; Humans ; Love ; Rare Diseases ; therapy

Caries risk assessment (CRA) involves a combination and analysis of factors including individual's age, biological factors, and protective and clinical findings. CRA significantly guides pediatric dentists and oral health caregivers in their decision-making plan for clinical treatment. The following is an introduction on the aspects of harmfulness of childhood caries and CRA for children of different ages.
Child ; Dental Caries ; Humans ; Oral Health ; Risk Assessment ; Risk Factors

Hyperoxia-induced lung injury in neonatal is a common complication after the clinical high oxygen therapy. There is not specific and effective prevention and treatment. Recent research suggests that many factor play an important role in the repair and protection of hyperoxia-induced lung injury in neonatal, such as growth factor, bone marrow mesenchymal stem cells,erythropoietin, anti-chemokine and anti-oxidation. The article reviews the molecular systems mechanisms in the pathologic process of hyperroxia-induced lung injury in neonatal.

1,25-dihydroxyvitamin D3 plays a role in the regulation of T cells, B cells, macrophages,dendritic cells,and keratinocytes. 1,25-dihydroxyvitamin D3 is linked to many autoimmune diseases, including rheumatoid arthritis,juvenile diabetes, Crohn's disease, multiple sclerosis. It may have potential as a treatment for autoimmune diseases, however, additional research will focus on better quantify dosage and course of treatment.

China is the country with the biggest diabetic population in the world.Diabetes has become a heavy financial burden for diabetic patients,families,and society.This article briefly described pharmacoeconomic concepts and analysis methods,and systemically reviewed literatures in health economic data of DPP-4 inhibitors,in the hope of providing a new perspective for clinicians,researchers,and health care policy makers.

Obesity is associated with numerous metabolic abnormalities, including insulin resistance and type 2 diabetes. Losing weight is an effective way of improving insulin sensitivity, thus decreasing the risk of obesityassociated diabetes and chronic cardiovascular disease. There is evidence that Liraglutide, as a human glucagon-like peptide-1 ( GLP-1 ) analogue, either using alone or combining with other glucose-lowering drugs, has effect on improving glycemic control, protecting β-cell function, and reducing body weight via inhibiting feeding behavior and delaying gastrointestinal motility. Therefore, liraglutide is a new option for treating type 2 diabetes patients.

Objective To investigate the clinical effect of early laparoscopic cholecystectomy in the treat -ment of elderly patients with acute cholecystitis .Methods 68 elderly patients with early acute cholecystitis were di-vided into the two groups according to the surgical procedures .33 cases in OC group were given traditional open sur-gery,while 35 cases in LC group received early laparoscopic cholecystectomy .The operative time,postoperative bowel recovery time and postoperative hospital stay time were compared between the two groups .Results The operative time,postoperative bowel recovery time ,postoperative hospital stay time in LC group were (43.7 ±5.8)min,(36.4 ± 3.9)h,(4.8 ±1.4)d,which were significantly shorter than (68.6 ±7.3)min,(65.2 ±4.5)h,(8.3 ±2.9)d in the OC group(t=3.317,3.862,3.029,all P<0.05).The incidence rate of postoperative complication of LC group was 14.29%,which of the OC group was 24.24%,the difference was not significant(P>0.05).Conclusion Early lap-aroscopic cholecystectomy in the treatment of elderly patients with acute cholecystitis can significantly shorten the operation time, promote postoperative recovery of gastrointestinal function and reduce postoperative hospital stay , reduce the burden of patients ,improve the quality of life and the incidence rate of complications is low .

Objective To quantitatively detect CA125 with self-designed synthetic gold nanoparticle probes by the colorimetric immunoassay and to initially investigate the feasibility of clinical application .Methods The capture antibody of detective CA125 was conjugated to the gold nanoparticle surface for preparing the gold nanoparticle probes .The gold nanoparticle aggregation was formed by the antigen-antibody immunoreaction .CA125 was quantitatively detected by the colorimetric immunoassay .Results The gold nanoparticle probes was successfully prepared ,which could detect the serum CA125 content rapidly and conveniently ,the de-tection results were coincident with the pathological diagnosis .The lowest limit of quantitation was 0 .5 U/mL ,which was far lower than that in ELISA .Conclusion This gold nanoparticle probes are simple to be prepared ,rapid and easy to operate with low cost , and have the important application value in clinical early detection of ovarian cancer marker CA 125 ,especially in the primary hospi-tals .

Objective To evaluate the efficacy and toxicity of gimeracil and oteracil porassium capsules combined with nedaplatin in the treatment of the patients with distant metastatic nasopharyngeal carcinoma.Methods Fourty cases were randomly divided into the observation group and control group by random digital table.19 cases in the observation group were treated with oteracil potassium capsules combined with nedaplatin.21cases in the observation group were treated with gemcitabine combined with nedaplatin.The response rate,response rate(RR) and progression free survival(PFS),toxicity were evaluated according to response evaluation criteria in solid tumors (RECIST).Results The response rate were 52.6％,52.3％ respectively,the median progression-free survival were 5.5 and 5.2 months,respectively.Grade Ⅲ an Ⅳ platelet supression were 10.5％,38.0％ between the observation group and control group.It was statistically significant between the two group(x2 =4.89,P ＜ 0.05).Conclusion Oteracil porassium capsules combined with nedaplatin is similar with gemcitabine combined with nedaplatin in the distant metastatic nasopharyngeal carcinoma,the adverse reaction was lighter than that of the control group.

Objective:To explore the relationship between serum uric acid (SUA) level and restenosis after percutane-ous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) .Methods:A total of 389 patients , who were diagnosed as ACS and received PCI in our hospital from Jan 2010 to Dec 2013 ,were selected .The 82 pa-tients with hyperuricemia were regarded as hyperuricemia group ,and the remaining patients with normal SUA level were treated as normal SUA group (n= 307) .Clinical condition and restenosis after PCI were observed and com-pared between two groups .Results:Compared with normal SUA group ,there were significant rise in percentages of hypertension (41.04% vs .58.54% ) ,Killip> class Ⅰ (16.61% vs .26.83% ) and multi-vessel coronary disease (50.16% vs .64.63% ) ,restenosis rate after PCI (9.12% vs .15.85% ) in hyperuricemia group ,P<0.05 all .Con-clusion:Serum uric acid level is closely related to restenosis rate after PCI in ACS patients ,which is worth attention .