Hyperoxia-induced lung injury in neonatal is a common complication after the clinical high oxygen therapy. There is not specific and effective prevention and treatment. Recent research suggests that many factor play an important role in the repair and protection of hyperoxia-induced lung injury in neonatal, such as growth factor, bone marrow mesenchymal stem cells,erythropoietin, anti-chemokine and anti-oxidation. The article reviews the molecular systems mechanisms in the pathologic process of hyperroxia-induced lung injury in neonatal.

1,25-dihydroxyvitamin D3 plays a role in the regulation of T cells, B cells, macrophages,dendritic cells,and keratinocytes. 1,25-dihydroxyvitamin D3 is linked to many autoimmune diseases, including rheumatoid arthritis,juvenile diabetes, Crohn's disease, multiple sclerosis. It may have potential as a treatment for autoimmune diseases, however, additional research will focus on better quantify dosage and course of treatment.

The anthor introduced the status of acupuncture and moxibustion treatment in Victoria hospitals of Seychelles in detail based on his own working experiences.The kinds of diseases,careers of patients,therapeutic effects and so on for acupuncture and moxibustion treatment were summarized.Meanwhile,the author outlined the development history of acupuncture and moxibustion in Seychelles,and put forward that acupuncturists should well handle four aspects of things including culture,psychological difference,English level and therapeutic effects to stay in conformance with the new development.

At present,the standard for the diagnosis of ventilator-associated pneumonia(VAP)is imperfect.The risk factors of VAP include body position, medical staffing, invasive procedure and so on. To strengthen the education and management of medical staff, improve the standard of care and breast feeding can reduce the incidence rate of VAP.There are controversial that H2 blockers/sucralfate, selective digestive tract decontamination and topical treatment with skin barrier can reduce the incidence rate of VAP. Common pathogenic bacteria of VAP are Klebsiella pneumoniae,Escherichia coli,Pseudomonas aeruginosa,Baumanii and so on in our country.Compreh-ensive prevention and treatment measures including selection of antibiotics appropriately and generalized supportive therapy should be applied.

Obesity is associated with numerous metabolic abnormalities, including insulin resistance and type 2 diabetes. Losing weight is an effective way of improving insulin sensitivity, thus decreasing the risk of obesityassociated diabetes and chronic cardiovascular disease. There is evidence that Liraglutide, as a human glucagon-like peptide-1 ( GLP-1 ) analogue, either using alone or combining with other glucose-lowering drugs, has effect on improving glycemic control, protecting β-cell function, and reducing body weight via inhibiting feeding behavior and delaying gastrointestinal motility. Therefore, liraglutide is a new option for treating type 2 diabetes patients.

Objective To discuss the ultrasonic features of iliac artery blocked and way of collateral circulation,in order to provide the basis for discovering the illness early and treating methods,provide the reference for judging the prognosis of illness.Methods 5 patients with iliac artery blocked and diagnosed by ultrasound were selected,including 4 arteriosclerosis patients and 1 non-arteriosclerosis patient.The ultrasound showed the blood flow in the limb from the beginning to the end and after the establishment of the circulation.But it was difficult to show the way of collateral circulation.Results It was right to get the treatmentconfirmed by DSA.The ultrasound can judge the iliac artery blocked correctly.It can show the situation of the vessel lemon that was blocked and the blood flow in blocked lower segment inside limb clearly.It can check the flow rate and the index of the resistance.It showed low speed(＜30cm/s) and low resistance (＜ 0.65).But it was difficult to show the way of collateral circulation.Conclusion CDFI is the right way to check the stenosis or blocked in iliac artery.It can ascertain the llow rate in the collateral circulation.Then it can judge the ability of compensation.But it is difficult to show the way of collateral circulation.

AP-2,a nuclear transcription factor family,always binds to a typical DNA sequence in the dimer way,thus AP-2 can regulates the expression of many other genes and participate in the growth and devel-opment, apoptosis and many other physiological processes. Under pathological conditions, AP-2 also plays an im-portant role in tumor genesis and development by influencing cell proliferation, differentiation, cell cycle regula-tion and apoptosis. Recent years,many researchers want to find new therapeutic strategies that target AP-2 in a series of human cancers.

China is the country with the biggest diabetic population in the world.Diabetes has become a heavy financial burden for diabetic patients,families,and society.This article briefly described pharmacoeconomic concepts and analysis methods,and systemically reviewed literatures in health economic data of DPP-4 inhibitors,in the hope of providing a new perspective for clinicians,researchers,and health care policy makers.

Objective: To observe effect of long-term treatment with removing heat and dampness and regulating collateral method on urinary protein in the patient of chronic nephritis. Methods: 43 cases of chronic nephritis were treated by removing heat and dampness and regulating collateral method for one year and the therapeutic effect was observed. Results: Proteinuria was obviously improved in the patient of chronic nephritis. Conclusion: The removing heat and dampness and regulating collateral method is effective for chronic proteinuria in the patient of chronic nephritis. Tripterygium Wilfordii is beneficial to control of proteinuria.

The involution of female Swiss mouse thymus induced by estradiol (Es_2) were studied by morphological methods.The involuting thymuses of 2-month-old mice increased greatly in weight after ovariectomy. Treated with Es_2, the thymuses of immature mice not only stopped growing, and also involuted apparently. The regeneration of thymuses was impeded in the mice whose thymuses had already involuted induced by hydrocortisone when treated with Es_2. These results proved the obvious inhibiting and involution-inducing effects of Es_2 on thymus. The pattern of the thymus involution induced by Es_2 was different from that by hydrocortisone. Es_2 had no lethal effect on thymocytes either in vivo or in vitro, but it reduced the proliferative rate of thymocytes slowly and caused the thymus involution gradually. Es_2 made no remarkable changes in weight and histology of adrenal glands. Thymus involution induced by Es_2 was also detected in adrenalectomized mice. These results indicated that thymus involution induced by Es_2 was adrenal independent. Accompanying the thymus involution, the number of type Ⅰ thymic epithelial cells decreased, which were considered to produce thymic hormones actively, and the structure of thymic epithelial cells denatured. These morphological degenerative alterations suggest that Es_2 can result in some changes or decline of the hormone secretory activity of thymic epithelial cells, and then the proliferation of thymocytes will reduce and thymus involution will take place.