Objective To find out the quality of brain function electromagnetic adjuvant therapy for neurosis treatment.Methods 100 patients were randomly divided into two groups,study group(50 cases)was treated for brain function by electromagnetic therapy with the drug treatment,and only drug treatment was used for the control group(50 cases).The psychological symptom checklist(SCL-90)and Pittsburgh Sleep Quality Index Scale(PSQI)were used to assess clinical symptoms and sleep quality of the two groups before and after therapy of 30 days,and the scale results were compared.Results After treatment,somatization,interpersonal sensitivity,anxiety,depression,hostility,phobia,obsessive-compulsive disorder,paranoid and psychotic items score of SCL-90 scale of study group was significantly lower than the scale before treatment(all P ＜0.05);after treatment somatization and anxiety item scores of SCL-90 scale of study group were significantly lower than the control group(all P ＜0.05).After treatment PSQI total scale score,sleep latency,sleep continuity,sleep efficiency,the use of sleep medications and sleep disorders of study group were significantly lower than before treatment(all P ＜ 0.01);after treatment PSQI total scale score and all items scores of study group were significantly lower than the control group(all P ＜ 0.05).Conclusion Adjuvant treatment of brain electromagnetic had significant effects of improving sleep quality,relieving anxiety and somatization for neurological patients.

Coenzyme Q (CoQ),also known as ubiquinone,is a lipid-soluble quinone compound which exists in biological organis ms widely.The numbers of side chain isoprene of different sources of coenzyme Q are different.Coenzyme Q in humans and mammals are called coenzyme Q10 (CoQ10 ,Q10 ), in that the ubiquinone side chain of humans and mammals are mainly composed of 10 isoprene units.In the mitochondrial respiratory chain,it acts as a mobile electron transporter and is a cofactor of uncoup-ling proteins,which is an essential endogenous substance in the process of cell respiration and metabo-lis m.Moreover,CoQ possesses independent antiapoptosis feature,which regulates the mitochondrial permeability transition pore.Mitochondrion is an important organelle,which is the place for energy stor-age and supply,providing the energy for vital movement.There are various kinds of chemical toxicants in the hu man environ ment,and they can enter into the hu man body through drinking,feeding or breath-ing and then affect cell mitochondria to different degrees.Thus,it is important for preventive medicine to investigate intervention or reduction of the biological da mage of exogenous chemicals′effects on mito-chondria.In this paper,we reviewed the research progress of the role of coenzyme Q in xenobiotics in-duced mitochondrial da mage.

One case of schistosomiasis got drug fever after taking praziquantel.

Objective:To observe the efficacy of A clotrimazole combined with ultrasonic atomization of ozone in the treatment of candidal vaginitis. Methods:Totally 200 cases of candidal vaginitis were divided into the observation group and the control group with 100 cases in each. The control group was given A clotrimazole creams through vaginal administration, qd, while the observation group was treated by ultrasonic atomization of ozone additionally, qd, 15min per time with five times. The clinical efficacy and the recurrence rate after 6 months of the two groups were compared. Before the treatment and in the first and fourth week after the treatment, vaginal secretion bacterial culture was performed and pH value was detected. Results:The cure rate and the total effective rate of the observa-tion group was 88% and 98%, respectively, which was significantly higher than that of the control group (69% and 82%, respective-ly, P<0. 05). After the 6-month follow-up, the recurrence rate was 1. 0% in the observation group (1/98), which was significantly lower than that in the control group [7. 3%(6/82),P<0. 05]. After the treatment, the vaginal pH value in the observation group was reduced notably and the number of lactobacillus was increased significantly(P<0. 05), while those in the control group were without significant changes (P>0. 05). Conclusion:A clotrimazole combined with ultrasonic atomization of ozone in the treatment of candidal vaginitis can improve the therapeutic effect.

Humans ; Severe Acute Respiratory Syndrome ; diagnosis ; drug therapy ; prevention & control

Anti-Asthmatic Agents ; therapeutic use ; Asthma ; drug therapy ; physiopathology ; Chronic Disease ; Humans ; Long-Term Care ; Lung ; physiopathology ; Respiratory Function Tests ; Severity of Illness Index ; Treatment Outcome

Objective To investigate the influence of continuous infusion of low-dose dexmedetomidine (DEX) on the hemodynamic in elderly surgical patients during induction of combined spinal-epidural anesthesia (CSEA).Methods Fifty elderly lower limb surgical patients were randomly divded into DEX group and control group(25 cases each).After the cannulation of left radial artery,the non-invasive hemodynamic monitor was connected,and the hemodynamic index was continuously monitored,including systolic blood pressure (SBP),diastolic blood pressure(DBP),heart rate(HR);and respiratory index was monitored,including respiration rate(RR),pulse oxygen saturation( SpO2 ).Before CSEA,the patients in DEX group were administered DEX of loading dose(0.5 μg · kg-1),then continuously infused with DEX at 0.2 ～ 0.4μg · kg-1 · h-1 to keep Ramsay sedation score from 4point to 5point,and SpO2 ≥95％.Normal saline was administered with an equal volume in control group.The SBP,DBP,HR,RR,SpO2 were recorded immediately at the T0,T1,T2,T3,T4 and T5.Results All hemodyanmic and respiratory parameters in both groups were normal during induction.Compared with T2 in DEX group,differences of SBP and DBP between two groups were statistically significant,and the value significantly lower at T3 (P ＜ 0.05 ) ;compared T2 with T1 in control group,differences of SBP,DBP and HR among three groups were statistically significant,and the value was significantly higher at T2 ( P ＜ 0.05 ).Compared with T2,SBP,DBP,HR were significantly lower than T3,( P ＜0.05).And RR of T1,T2,T3,T4,T5 in DEX group was significanfly lower than T0,with statistical significance( P ＜0.05) ;the difference of RR among different time was not statistically significant in control group(P ＞ 0.05 ).Conclusion The continuous infusion of small-dosage DEX during CSEA in elderly lower limb surgical patients may have little impact on cardiac function index when achieved effective sedation and analgesia.

Objective To evaluate the effects of carvedilol on the cardiac function and serum leptin lever in the treatment of diabetic cardiomyopathy.Methods 40 patients with diabetic cardiomyopathy were randomly divided into carvedilol group and control group.Two groups were given normal therapy and the carvedilol group added carvedilol.The serum levels of leptin and insulin and the heart ultrasound check were measured before and after six months of therapy.Results After therapy the serum levels of leptin and insulin resistance index [ ( 7.18 ± 2.06 ) μg/L,(2.92 ± 0.62) ] were blower than that before therapy in carvedilol group but not control group.After therapy the value of LVEF and E/A were higher[ (46.9 ± 6.8) ％,( 1.05 ± 0.07) ] and LVMI and LVEDd were lower[ ( 108 ± 6 ) g/ m2,(51.8 ± 5.7)mm ] than that before therapy in carvedilol group but not control group( all P ＜ 0.05 ).Conclusion Carvedilol could decrease the levels of serum leptin in patient with diabetic cardiomyopathy and improve insulin resistance and left entricular function.

In the cross-cutting areas of information science and life science,a subdiscipline—digital medicine is established.As a new subdiscipline,several problems need to be resolved for the development of digital medicine. Paying attention to actual benefits and fulfilling the need in clinical practice are the demand for digital nedicine,and they are also the spirit of translational medicine. Deeply rooted in clinical practice and oriated by the requirement of clinicians are helpful for a healthier development of digital medicine research.