OBJECTIVE: To study the protective effects of nimesulide, a COX- 2 selective inhibitor on experimental gastric ulcer in rats. METHODS: The gastric ulcer model was established in rats by intragastric administration them with indometacin, 5 min later, which were assigned to receive nimesulide at different dosages ( 200, 100, and 50mg? kg- 1) , 6h later, all the rats were sacrificed. The primary outcome measures were the area of ulcer, levels of SOD, MDA, and GSH in sera and gastric mucosa. RESULTS: As compared with model group, in nimesulide ( at different dosage) groups, the area of ulcer was markedly decreased, level of MDA was decreased while activities of SOD and GSH were increased ( P

With the improvement of the therapy and the drugs we known more results in a therapeutic ambitious goals of juvenile idiopathic arthritis.Selection of individualized sequential therapy is beneficial to the recovery of the disease.

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Standardized management for medical equipment department of the second-class traditional Chinese medical hospital is of great importance to enhance working and economic efficiencies. When standardized management performed, it's suggested that related organization, regulation as well as maintenance and file management be involved in.

Objective To discuss how to deal with the problems of LEEP electro-scalpel that are caused by the burn of negative electrode loose and the electric shock of leakage current.Methods The system's security was enhanced by insulation,power and software control and it was also evaluated.Results The electric leakage of LEEP electro-scalpel was acceptable and the preventive support of burn was effective.Conclusion It is proved by the synthetical evaluation that the device's secure design is reliable.

The test procedure and content of valves pressure test of AK95 hemodialysis machine are mainly introduced.The valves pressure test are the key of the self test procedure in hemsdialysis machine.It is necessary to find the accurate process where problems occur.[Chinese Medical Equipment Journal,2008,29(2):94]

The BM self-test of GAMBRO AK95 hemodialysis machine is introduced, including venous pressure test, arterial pressure test, priming detector test, blood pump test, venous clamp test, arterial clamp test, air detector test, high venous pressure test, etc. The detail introduction of high venous pressure test is of great benefit to solve some faults of hemodialysis machine.

Objective:To map the approximate transcription factors binding site of Visfatin and identify its potential promoter region.Methods:All reported transcripts of Visfatin were collected through searching online database.Visfatin gene were analysed by CpG/CpGReport/Isochore and FirstEF to predict the CpG island and possible first exon,respectively.The Visfatin gDNA sequence was also analysed by softwares such as PromoterScan to predict the probable promoter region.Matlspector、TFSEARCH and Match were used to predict potential transcription factors binding sites.Results:Among all the reported transcripts of Visfatin,5'UTR of NM_005746 Was the longest.Visfatin gene Was a typical CpG island associated gene.Promoters were predicted in the NM_005746 5'upstream 229～798bp region.In this region,a lot of cis-acting element were found. Conclusion:The transcription initiation site of Visfatin have been indentifiod.A lot of transcription factors binding sites were predict in the NM 005746 5' upstream 229-798bp region.It is important to definite those transcription factors binding sites through experimental methods.

Objective:To study the expression of Bcl-2 protein in the brain tissue of paitents with drug-refractory epilepsy and its clinical value. Methods:immunohistochemistry、immunofluorescence were used to detect the expression of Bcl-2 protein in the surgically removed brain tissue of patients with drug-refractory epilepsy from the brain bank of our department(n=20),and the results were compared with that of normal controls(n=20). Results:Bcl-2 protein expression was significantly increased in temporal lobe cortex and hippocampus of patients with drug-refractory epilepsy compared with controls in the same regions, and there was significant difference between patient group and control group by t-test. Conclusion:The results indicate that the overexpression of Bcl-2 in the cortex of temporal lobe and hippocampus may be involved in the pathophysiology of drug-refractory epilepsy.

Objective:To observe the clinical effects of Tip-Edge Plus appliance in treating bimaxillary protrusion patients and discuss its mechanics. Methods:20 patients with bimaxillary protrusion were treated with Tip-Edge Plus appliance. 4 premolars in all those cases were extracted. The results of cephalometric measurements of pretreatment and posttreatment were statistically analyzed to evaluate orthodontic effects. Results:20 patients received an average of 18 months of treatment,after treatment dental coverage and molar relations of these patients were in the normal range. Analysis of related projects cephalometric showed that patients with lateral outlook improved significantly,SNA,SNB and U1~L1 angle changes in hard tissue with significant difference in cephalometric measurements(P